Nonpharmacologic treatments
Protocol amendment:
As of March 1, 2022, the COVID-NMA stopped including non pharmacological interventions trials. The analysis presented in this page includes trials identified and included up to Feb 28, 2022.
Please choose a Treatment Comparison:
- Auricular Neuromodulation vs Placebo (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Balloon-Blowing vs Standard care (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Continuous positive airway pressure vs Conventional oxygen therapy (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Continuous positive airway pressure vs High-flow nasal oxygenation (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- High Flow Nasal Cannula vs Standard non rebreathing mask (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- High-flow nasal oxygenation vs Standard bag valve mask oxygenation (1 RCTs) - This comparison will not be updated. Last search date 28 Feb, 2022.
- High-flow nasal oxygenation vs Noninvasive ventilation (2 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- High-flow nasal oxygenation vs Conventional oxygen therapy (2 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Hyperbaric oxygen therapy vs Standard care (2 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Low-Dose Radiation Therapy vs Sham irradiation/Standard of care (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Oxygen-Ozone vs Standard Care (2 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Photobiomodulation therapy vs Standard care/Placebo (2 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Prone position vs Standard care (4 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Pulmonary physiotheraphy vs Standard care (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Short-wave diathermy vs Placebo (2 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
- Thermal helium-oxygen mixture vs Standard care (1 RCTs) - This comparison will not be updated. Last search date Feb 28, 2022
Description of primary studies
| Trial | Funding | Comparisons | Design | Participants | Sample size | Overall risk of bias Highest assessment |
Full description | |
|---|---|---|---|---|---|---|---|---|
| Treatment 1 | Treatment 2 | |||||||
| IRCT20201012049010N1 Bargahi M, medRxiv, 2021 Full text Commentary Commentary |
Public/non profit | Balloon-Blowing | Standard care | RCT | Patients with suspected or confirmed COVID-19 (severe) admitted to a single center in Iran | N=83 | N/A | |
| NCT04477954 Cannellotto M, Emerg Med J, 2021 Full text Commentary Commentary |
Private | Hyperbaric oxygen therapy | Standard care | RCT | Patients with confirmed COVID-19 (severe) admitted to 3 centers in Argentina. | N=40 |
Some concerns Details |
|
| NCT04386694 De Marchi T, J Inflamm Res, 2021 Full text Full text Commentary Commentary |
Mixed | Photobiomodulation therapy | Placebo | RCT | Patients with confirmed COVID-19 (critical) admitted to a single center in Brazil. | N=30 |
Some concerns Details |
|
| N/A Dengiz E, Med Gas Res, 2021 Full text Commentary |
Private | Oxygen-Ozone | Standard care | RCT | Patients with confirmed COVID-19 (symptomatic, unclear severity) admitted to a single center in Turkey. | N=30 |
Some concerns Details |
|
| NCT04325906, NCT04347941, NCT04358939, NCT04395144 Ehrmann S, Lancet Respir Med, 2021 Full text Commentary Commentary |
Mixed | Prone position | Standard care | RCT | Patients with confirmed or suspected COVID-19 (severe) admitted to 42 centers in Canada (4 centers), France (27), Ireland (3), Mexico (2), USA (4) and Spain (2). | N=1126 |
Some concerns Details |
|
| NCT04502576 Grieco DL, JAMA, 2021 Full text Commentary Commentary Commentary |
Not reported/unclear | Helmet noninvasive ventilation | High-flow nasal oxygenation | RCT | Patients with confirmed COVID-19 (severe) admitted to 4 centers in Italy | N=110 |
Some concerns Details |
|
| NCT04358926 Hadanny A, SSRN, 2021 Full text Commentary Commentary |
Public/non profit | Hyperbaric oxygen therapy | Standard care | RCT | Patients with confirmed COVID-19 (severe) admitted to a single center in Israel | N=29 |
High Details |
|
| ChiCTR2000029972 Huang L, medRxiv, 2021 Full text Commentary Commentary |
Public/non profit | Short-wave diathermy | Standard care | RCT | Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in China | N=50 |
Some concerns Details |
|
| Short-wave diathermy | Standard care | |||||||
| NCT04221737 Ibarra-Estrada MA, Crit Care Med, 2021 Full text Commentary |
Not reported/unclear | Airway pressure release ventilation (APRV) | low tidal volume (LTV) ventilation | RCT | Patients with confirmed COVID-19 (critical) admitted to a single center in Mexico. | N=101 |
Some concerns Details |
|
| NCT04357340 Javaherian M, medRxiv, 2021 Full text Commentary Commentary |
Public/non profit | Pulmonary physiotherapy | Standard care | RCT | Patients with confirmed COVID-19 (severe) admitted to a single center in Iran | N=40 |
Some concerns Details |
|
| CTRI/2020/12/029702 Jayakumar D, J Intensive Care Med, 2021 Full text Commentary |
No specific funding | Awake-Prone Positioning Strategy | Standard care | RCT | Patients with confirmed COVID-19 (severe) admitted to 3 centers in India | N=60 |
Some concerns Details |
|
| SNCTP000003718 Kharat A, ERJ Open Res, 2021 Full text Commentary |
No specific funding | Prone Position | Standard care | RCT | Patients with suspected or confirmed COVID (moderate-severe) admitted to a single center in Switzerland. | N=27 |
High Details |
|
| CTRI/2020/07/026835 Nair PR, Respir Care, 2021 Full text Commentary |
Public/non profit | High flow nasal cannula | Noninvasive ventilation | RCT | Patients with confirmed COVID-19 (severe) admitted to a single center in India. | N=109 |
Some concerns Details |
|
| CTRI/2021/01/030829 Nazir N, Research Square, 2021 Full text Commentary Commentary |
No specific funding | High flow nasal cannula | Non-rebreathing mask | RCT | Patients with confirmed COVID-19 (moderate/severe) admitted to a single center in India. | N=60 |
Some concerns Details |
|
| NCT04609462 Ospina-Tascon GA, JAMA, 2021 Full text Commentary |
Public/non profit | High-flow nasal oxygenation | Conventional oxygen therapy | RCT | Patients with confirmed COVID-19 (moderate-severe) admitted to 3 centers in Colombia. | N=220 |
Some concerns Details |
|
| NCT04581811 Page DB, Ann Am Thorac Soc, 2021 Full text Commentary |
No specific funding | Prolonged Proning | Traditional Proning | RCT | Patients with confirmed COVID-19 (critical) admitted to a single center in USA | N=52 |
Some concerns Details |
|
| NCT04598581 Papachristofilou A, Int J Radiat Oncol B, 2021 Full text Commentary Commentary Commentary |
Not reported/unclear | Low-Dose Radiation Therapy | Sham Radiation Therapy | RCT | Patients with confirmed COVID-19 (severe-critical) admitted to a single center in Switzerland. | N=22 |
Some concerns Details |
|
| ISRCTN 16912075 Perkins G, RECOVERY-RS, 2021 Full text Commentary Commentary |
Public/non profit | Continuous positive airway pressure | Conventional oxygen therapy | RCT | Patients with suspected or confirmed COVID-19 (severe) admitted to 48 centers in the UK | N=1272 |
Some concerns Details |
|
| High-flow nasal oxygenation | Conventional oxygen therapy | |||||||
| Continuous positive airway pressure | High-flow nasal oxygenation | |||||||
| NCT04341415 Rangon CM, Front Physiol, 2021 Full text Commentary Commentary |
Private | Auricular Neuromodulation | Placebo | RCT | Patients with suspected or confirmed COVID-19 (moderate-severe) admitted to 2 centers in France. | N=29 |
Some concerns Details |
|
| ISRCTN54918435 Rosen J, Crit Care, 2021 Full text Full text Commentary Commentary |
Public/non profit | Prone position | Standard care | RCT | Patients with confirmed COVID-19 (severe) admitted to 3 centers in Sweden | N=75 |
Some concerns Details |
|
| CTRI/2020/07/026354 Shah M, Int Immunopharmacol, 2021 Full text Commentary |
Private | Oxygen-Ozone | Standard care | RCT | Patients with confirmed COVID-19 (mild) admitted to a single center in India | N=60 |
High Details |
|
| N/A Shogenova LV, Pulmonologiya, 2020 Full text Commentary |
Thermal helium-oxygen mixture | Standard care | RCT | Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Russia | N=60 |
Some concerns Details |
||
| NCT04388514 Sozio E, Int Immunopharmacol, 2021 Full text Commentary |
No specific funding | Oxygen-Ozone | Standard care | RCT | Patients with confirmed COVID-19 (moderate-severe) admitted to 4 centers in Italy. | N=96 |
Some concerns Details |
|
| N/A Tian F, Eur J Phys Rehabil Med, 2021 Full text Commentary |
Public/non profit | Short-wave diathermy | Placebo | RCT | Patients with confirmed COVID-19 (mild-severe) admitted to a single center in China | N=42 |
Some concerns Details |
|
| NCT04391712 Vetrici MA, J Inflamm Res, 2021 Full text Commentary |
No specific funding | Photobiomodulation therapy | Standard care | RCT | Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in the USA | N=10 |
Some concerns Details |
|
| ChiCTR2000029658 Wu CN, Br J Anaesth, 2020 Full text Commentary |
Public/non profit | HFNO | Mask | RCT | Patients with confirmed COVID-19 pneumonia and hypoxaemia (critical) admitted to | N=60 |
Some concerns Details |
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