Nonpharmacologic treatments

We are searching the literature every day and collecting data for each randomized controlled trial of COVID-19 treatment identified.

Below you can access all the treatment comparisons where data are available as well as a table with the general characteristics of each trial. For each treatment comparison you can access the forest-plots for all the outcomes of interest available as well as the Summary of Findings (SoF) table (development in process).

We systematically stratified the results on the disease severity (mild/moderate vs moderate/severe/critical)

Each week we are updating the evidence synthesis.

Description of primary studies

In this table, we report the main characteristics of the randomized trials identified.

The link in the column "Overall risk of bias" will give you access to a complete description of the assessment of each risk of bias domain with supports for judgement.

The overall risk of bias reported in the table correspond to the risk of bias for the primary outcome.

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Full description
Treatment 1 Treatment 2
Wu CN, Br J Anaesth, 2020
Full text
30135-5 Commentary
Unclear High-flow nasal oxygenation Standard bag valve mask oxygenation RCT Patients with confirmed COVID-19 pneumonia and hypoxaemia (critical) admitted to a single center in China. N=60
Some concerns
Full description

We acknowledge that we may have been unable to extract some information from pre-prints, as they represent preliminary forms of scientific communication. We perform daily database searches to identify if an included pre-print has been published in a scientific journal, and we will use the published paper to update our extraction

We recognize that our process might not be perfect. Please contact us if you identify an error