Nonpharmacologic treatments

Protocol amendment:

As of March 1, 2022, the COVID-NMA stopped including non pharmacological interventions trials. The analysis presented in this page includes trials identified and included up to Feb 28, 2022.

Methods

Please choose a Treatment Comparison:

  • Auricular Neuromodulation vs Placebo (1 RCTs)
  • Balloon-Blowing vs Standard care (1 RCTs)
  • Continuous positive airway pressure vs Conventional oxygen therapy (1 RCTs)
  • Continuous positive airway pressure vs High-flow nasal oxygenation (1 RCTs)
  • High Flow Nasal Cannula vs Standard non rebreathing mask (1 RCTs)
  • High-flow nasal oxygenation vs Standard bag valve mask oxygenation (1 RCTs)
  • High-flow nasal oxygenation vs Noninvasive ventilation (2 RCTs)
  • High-flow nasal oxygenation vs Conventional oxygen therapy (2 RCTs)
  • Hyperbaric oxygen therapy vs Standard care (2 RCTs)
  • Low-Dose Radiation Therapy vs Sham irradiation/Standard of care (1 RCTs)
  • Oxygen-Ozone vs Standard Care (2 RCTs)
  • Photobiomodulation therapy vs Standard care/Placebo (2 RCTs)
  • Prone position vs Standard care (4 RCTs)
  • Pulmonary physiotheraphy vs Standard care (1 RCTs)
  • Short-wave diathermy vs Placebo (2 RCTs)
  • Thermal helium-oxygen mixture vs Standard care (1 RCTs)

Reboot the table and see all comparisons

Description of primary studies

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
IRCT20201012049010N1
Bargahi M, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit Balloon-Blowing Standard care RCT Patients with suspected or confirmed COVID-19 (severe) admitted to a single center in Iran N=83 N/A

Full description

NCT04477954
Cannellotto M, Emerg Med J, 2021
Full text
Commentary
Commentary
Private Hyperbaric oxygen therapy Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 3 centers in Argentina. N=40
Some concerns
Details

Full description

NCT04386694
De Marchi T, J Inflamm Res, 2021
Full text
Full text
Commentary
Commentary
Mixed Photobiomodulation therapy Placebo RCT Patients with confirmed COVID-19 (critical) admitted to a single center in Brazil. N=30
Some concerns
Details

Full description

N/A
Dengiz E, Med Gas Res, 2021
Full text
Commentary
Private Oxygen-Ozone Standard care RCT Patients with confirmed COVID-19 (symptomatic, unclear severity) admitted to a single center in Turkey. N=30
Some concerns
Details

Full description

NCT04325906, NCT04347941, NCT04358939, NCT04395144
Ehrmann S, Lancet Respir Med, 2021
Full text
Commentary
Commentary
Mixed Prone position Standard care RCT Patients with confirmed or suspected COVID-19 (severe) admitted to 42 centers in Canada (4 centers), France (27), Ireland (3), Mexico (2), USA (4) and Spain (2). N=1126
Some concerns
Details

Full description

NCT04502576
Grieco DL, JAMA, 2021
Full text
Commentary
Commentary
Commentary
Not reported/unclear Helmet noninvasive ventilation High-flow nasal oxygenation RCT Patients with confirmed COVID-19 (severe) admitted to 4 centers in Italy N=110
Some concerns
Details

Full description

NCT04358926
Hadanny A, SSRN, 2021
Full text
Commentary
Commentary
Public/non profit Hyperbaric oxygen therapy Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Israel N=29
High
Details

Full description

ChiCTR2000029972
Huang L, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit Short-wave diathermy Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in China N=50
Some concerns
Details

Full description

Short-wave diathermy Standard care
NCT04221737
Ibarra-Estrada MA, Crit Care Med, 2021
Full text
Commentary
Not reported/unclear Airway pressure release ventilation (APRV) low tidal volume (LTV) ventilation RCT Patients with confirmed COVID-19 (critical) admitted to a single center in Mexico. N=101
Some concerns
Details

Full description

NCT04357340
Javaherian M, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit Pulmonary physiotherapy Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran N=40
Some concerns
Details

Full description

CTRI/2020/12/029702
Jayakumar D, J Intensive Care Med, 2021
Full text
Commentary
No specific funding Awake-Prone Positioning Strategy Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 3 centers in India N=60
Some concerns
Details

Full description

SNCTP000003718
Kharat A, ERJ Open Res, 2021
Full text
Commentary
No specific funding Prone Position Standard care RCT Patients with suspected or confirmed COVID (moderate-severe) admitted to a single center in Switzerland. N=27
High
Details

Full description

CTRI/2020/07/026835
Nair PR, Respir Care, 2021
Full text
Commentary
Public/non profit High flow nasal cannula Noninvasive ventilation RCT Patients with confirmed COVID-19 (severe) admitted to a single center in India. N=109
Some concerns
Details

Full description

CTRI/2021/01/030829
Nazir N, Research Square, 2021
Full text
Commentary
Commentary
No specific funding High flow nasal cannula Non-rebreathing mask RCT Patients with confirmed COVID-19 (moderate/severe) admitted to a single center in India. N=60
Some concerns
Details

Full description

NCT04609462
Ospina-Tascon GA, JAMA, 2021
Full text
Commentary
Public/non profit High-flow nasal oxygenation Conventional oxygen therapy RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 3 centers in Colombia. N=220
Some concerns
Details

Full description

NCT04581811
Page DB, Ann Am Thorac Soc, 2021
Full text
Commentary
No specific funding Prolonged Proning Traditional Proning RCT Patients with confirmed COVID-19 (critical) admitted to a single center in USA N=52
Some concerns
Details

Full description

NCT04598581
Papachristofilou A, Int J Radiat Oncol B, 2021
Full text
Commentary
Commentary
Commentary
Not reported/unclear Low-Dose Radiation Therapy Sham Radiation Therapy RCT Patients with confirmed COVID-19 (severe-critical) admitted to a single center in Switzerland. N=22
Some concerns
Details

Full description

ISRCTN 16912075
Perkins G, RECOVERY-RS, 2021
Full text
Commentary
Commentary
Public/non profit Continuous positive airway pressure Conventional oxygen therapy RCT Patients with suspected or confirmed COVID-19 (severe) admitted to 48 centers in the UK N=1272
Some concerns
Details

Full description

High-flow nasal oxygenation Conventional oxygen therapy
Continuous positive airway pressure High-flow nasal oxygenation
NCT04341415
Rangon CM, Front Physiol, 2021
Full text
Commentary
Commentary
Private Auricular Neuromodulation Placebo RCT Patients with suspected or confirmed COVID-19 (moderate-severe) admitted to 2 centers in France. N=29
Some concerns
Details

Full description

ISRCTN54918435
Rosen J, Crit Care, 2021
Full text
Full text
Commentary
Commentary
Public/non profit Prone position Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 3 centers in Sweden N=75
Some concerns
Details

Full description

CTRI/2020/07/026354
Shah M, Int Immunopharmacol, 2021
Full text
Commentary
Private Oxygen-Ozone Standard care RCT Patients with confirmed COVID-19 (mild) admitted to a single center in India N=60
High
Details

Full description

N/A
Shogenova LV, Pulmonologiya, 2020
Full text
Commentary
Thermal helium-oxygen mixture Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Russia N=60
Some concerns
Details

Full description

NCT04388514
Sozio E, Int Immunopharmacol, 2021
Full text
Commentary
No specific funding Oxygen-Ozone Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 4 centers in Italy. N=96
Some concerns
Details

Full description

N/A
Tian F, Eur J Phys Rehabil Med, 2021
Full text
Commentary
Public/non profit Short-wave diathermy Placebo RCT Patients with confirmed COVID-19 (mild-severe) admitted to a single center in China N=42
Some concerns
Details

Full description

NCT04391712
Vetrici MA, J Inflamm Res, 2021
Full text
Commentary
No specific funding Photobiomodulation therapy Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in the USA N=10
Some concerns
Details

Full description

ChiCTR2000029658
Wu CN, Br J Anaesth, 2020
Full text
Commentary
Public/non profit HFNO Mask RCT Patients with confirmed COVID-19 pneumonia and hypoxaemia (critical) admitted to N=60
Some concerns
Details

Full description