Preventive treatments

Below you can access forest plots for all the treatment comparisons as well as the general characteristics of each trial with risk of bias assessment.

Analyses are updated every Friday.

Of note, the search “display new or updated results” may identify comparisons not tagged as ‘updated’ when a trial related to this comparison has been identified or updated and is reported in the table but is not yet included in the analysis.

More details about outcomes and Disease severity

Please choose a Treatment Comparison:

  • Hydroxychloroquine vs Standard care/Placebo
  • Ivermectin vs Standard care
  • Social distancing at sports training vs No access to sports training facilities
  • video training in PPE donning and doffing vs live instructor-led training in PPE donning and doffing

Reboot the table and see all comparisons

Description of primary studies

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04329923
Abella BS, JAMA Intern Med, 2020
Full text
Commentary
Commentary
Private Hydroxychloroquine Placebo RCT Healthcare worker with ≥20 hours per week of clinical work scheduled in the coming 2 months during the COVID-19 pandemic. N=132
Low
Details

Full description

NCT04328961
Barnabas R, Ann Intern Med, 2020
Full text
Commentary
Mixed Hydroxychloroquine Placebo RCT Household contacts of an index case (diagnosed with SARS-CoV2 infection with the past 14 days) or health care workers who cared for an index case without appropriate personal protective equipment recently exposed (<96 hours) N=829
Some concerns
Details

Full description

NCT04308668
Boulware DR, N Engl J Med, 2020
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Persons who had household or occupational exposure to a person with confirmed Covid-19 at a distance of less than N=821
Some concerns
Details

Full description

NCT04406909
Bretthauer M, medRxiv, 2020
Full text
Commentary
Public Social distancing at sports training facilities No access to sports training facilities RCT General public not at high risk for Covid-19 with membership to local sports training facilities. N=3764
High
Details

Full description

N/A
Christensen L, Disaster Med Public Health Prep, 2020
Full text
* video training in PPE donning and doffing live instructor-led training in PPE donning and doffing RCT Healthcare professionals receiving PPE use training in Denmark. N=21
Some concerns
Details

Full description

NCT04668469
Elgazzar A, 2020
Full text
Commentary
; Commentary
; Commentary
; Commentary
No specific funding Ivermectin Standard care RCT Healthcare (pre exposure) and/or household (post exposure) patients’ contacts of confirmed, symptomatic COVID-19 case N=200
Some concerns
Details

Full description

NCT04331834
Grau-Pujol B, Research Square, 2020
Full text
Commentary
Mixed Hydroxychloroquine Placebo RCT Healthcare workers with ongoing exposure to persons with Covid-19 N=269
High
Details

Full description

NCT04304053
Mitja O, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Adults with a recent history of close contact exposure to a PCR confirmed Covid-19 case and absence of Covid-19-like symptoms, as either a healthcare worker,a household contact, a nursing home worker or a nursing home resident. N=2525
Some concerns
Details

Full description

NCT04328467
Rajasingham R, medRxiv, 2020
Full text
Commentary
and Commentary
Mixed Hydroxychloroquine 400mg QW Placebo RCT Healthcare workers with ongoing exposure to persons with Covid-19 N=1483
Some concerns
Details

Full description

Hydroxychloroquine 400mg BW Placebo
Hydroxychloroquine 400mg QW Hydroxychloroquine 400mg BW
NCT04422561
Shouman W, 2021
Full text
Commentary
No specific funding Ivermectin Standard care RCT Asymptomatic household family members in close contact with cases of COVID-19 diagnosed and confirmed by Reverse Transcription- Polymerase Chain Reaction N=340
High
Details

Full description