Preventive treatments

We are searching the literature every day and collecting data for each RCT of COVID-19 treatment identified.

Below you can access all the treatment comparisons where data are available as well as a table with the general characteristics of each trial. For each treatment comparison, you can access the forest plots for all the outcomes of interest available as well as the Summary of Findings (SoF) table

Each week we are updating the evidence synthesis.

Please choose a Treatment Comparison:

Reboot the table and see all comparisons

Description of primary studies

In this table, we report the main characteristics of the RCTs identified.

The link in the column Overall risk of bias will give you access to a complete description of the assessment of each risk of bias domain with supports for judgement. The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review.

The link in the column Full description will give you access to the general characteristics of the study.

The components included in the standard of care vary among the included studies. For example, the standard of care may include antiviral treatments in some studies, but not in others. We are in the process of contacting the study authors to obtain more information.

We acknowledge that we may have been unable to extract some information from pre-prints, as they represent preliminary forms of scientific communication. We perform daily database searches to identify if an included pre-print has been published in a scientific journal, and we will use the published paper to update our extraction.

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Full description
Treatment 1 Treatment 2
NCT04329923
Abella BS, JAMA Intern Med, 2020
Full text
Commentary
Commentary
Private Hydroxychloroquine Placebo RCT Healthcare worker with ≥20 hours per week of clinical work scheduled in the coming 2 months during the COVID-19 pandemic. N=132
Low
Details

Full description

NCT04308668
Boulware DR, N Engl J Med, 2020
Full text
Commentary
Commentary
Private Hydroxychloroquine Placebo RCT Persons who had household or occupational exposure to a person with confirmed Covid-19 at a distance of less than N=821
High
Details

Full description

NCT04406909
Bretthauer M, medRxiv, 2020
Full text
Commentary
Public Social distancing at sports training facilities No access to sports training facilities RCT General public not at high risk for Covid-19 with membership to local sports training facilities. N=3764
High
Details

Full description

N/A
Christensen L, Disaster Med Public Health Prep, 2020
Full text
* video training in PPE donning and doffing live instructor-led training in PPE donning and doffing RCT Healthcare professionals receiving PPE use training in Denmark. N=21
Some concerns
Details

Full description

NCT04331834
Grau-Pujol B, Research Square, 2020
Full text
Commentary
Mixed Hydroxychloroquine Placebo RCT Healthcare workers with ongoing exposure to persons with Covid-19 N=269
High
Details

Full description

NCT04304053
Mitja O, medRxiv, 2020
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Adults with a recent history of close contact exposure to a PCR confirmed Covid-19 case and absence of Covid-19-like symptoms, as either a healthcare worker,a household contact, a nursing home worker or a nursing home resident. N=2525
Some concerns
Details

Full description

NCT04328467
Rajasingham R, medRxiv, 2020
Full text
Commentary
and Commentary
Mixed Hydroxychloroquine 400mg QW Placebo RCT Healthcare workers with ongoing exposure to persons with Covid-19 N=1483
Low
Details

Full description

Hydroxychloroquine 400mg BW Placebo
Hydroxychloroquine 400mg QW Hydroxychloroquine 400mg BW

We acknowledge that we may have been unable to extract some information from pre-prints, as they represent preliminary forms of scientific communication. We perform daily database searches to identify if an included pre-print has been published in a scientific journal, and we will use the published paper to update our extraction

We recognize that our process might not be perfect. Please contact us if you identify an error