Preventive treatments

Analyses are updated every Friday

Methods

Please choose a Treatment Comparison:

  • Bamlanivimab (LY-CoV555) vs Placebo (1 RCTs)
  • Bromhexine hydrochloride vs Standard care (1 RCTs)
  • Casirivimab+Imdevimab (REGN-COV2) vs Placebo (1 RCTs)
  • Hydroxychloroquine vs Standard care/Placebo (9 RCTs)
  • Hydroxychloroquine vs Vitamin C (1 RCTs)
  • Ivermectin vs Standard care (1 RCTs)
  • Ivermectin vs Vitamin C (1 RCTs)
  • Ivermectin+Iota Carrageenan vs Standard care (1 RCTs)
  • Lopinavir + Ritonavir vs Standard care (1 RCTs)
  • Povidone iodine vs Vitamin C (1 RCTs)
  • Social distancing at sports training vs No access to sports training facilities (1 RCTs)
  • Surgical mask vs Standard care (1 RCTs)
  • video training in PPE donning and doffing vs live instructor-led training in PPE donning and doffing (1 RCTs)
  • Zinc oxide+Vitamin C vs Vitamin C (1 RCTs)

Reboot the table and see all comparisons

Description of primary studies

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04329923
Abella BS, JAMA Intern Med, 2020
Full text
Commentary
Commentary
Private Hydroxychloroquine Placebo RCT Healthcare worker with ≥20 hours per week of clinical work scheduled in the coming 2 months during the COVID-19 pandemic. N=132
Some concerns
Details

Full description

NCT04328961
Barnabas R, Ann Intern Med, 2020
Full text
Commentary
Mixed Hydroxychloroquine Placebo RCT Household contacts of an index case (diagnosed with SARS-CoV2 infection with the past 14 days) or health care workers who cared for an index case without appropriate personal protective equipment recently exposed (<96 hours) N=829
Some concerns
Details

Full description

NCT04308668
Boulware DR, N Engl J Med, 2020
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Persons who had household or occupational exposure to a person with confirmed Covid-19 at a distance of less than N=821
Some concerns
Details

Full description

NCT04406909
Bretthauer M, medRxiv, 2020
Full text
Commentary
Public Social distancing at sports training facilities No access to sports training facilities RCT General public not at high risk for Covid-19 with membership to local sports training facilities. N=3764
High
Details

Full description

NCT04337541
Bundgaard H
Full text
Commentary
Commentary
Commentary
Commentary
Public Surgical mask Standard care RCT Workers with exposure to other people for more than 3 hours per day who do not normally wear a face mask, and who are community-dwelling adults aged 18 years or older without current or prior symptoms or diagnosis of COVID-19 N=6024
Some concerns
Details

Full description

NCT04701710
Chahla RE
Full text
Commentary
Commentary
No specific funding Ivermectin+Iota-Carrageenan Standard care RCT NR N=234
Some concerns
Details

Full description

N/A
Christensen L, Disaster Med Public Health Prep, 2020
Full text
Not reported/unclear video training in PPE donning and doffing live instructor-led training in PPE donning and doffing RCT Healthcare professionals receiving PPE use training in Denmark. N=21 N/A

Full description

NCT04497987
Cohen M, BLAZE-2, 2021
Full text
Commentary
Commentary
Mixed Bamlanivimab (LY-CoV555) Placebo RCT NR N=1175

Details

Full description

NCT04331834
Grau-Pujol B, Research Square, 2020
Full text
Commentary
Mixed Hydroxychloroquine Placebo RCT Healthcare workers with ongoing exposure to persons with Covid-19 N=269
High
Details

Full description

NCT04364022; SNCTP 000003732
Labhardt N, COPEP, 2021
Full text
Commentary
Public/nonprofit Lopinavir-Ritonavir Standard care RCT Asymptomatic individuals ?16 years close contacts with a person with a confirmed SARS-CoV-2 infection N=321
Some concerns
Details

Full description

NCT04405999
Mikhaylov E
Full text
Commentary
Commentary
Public/nonprofit Bromhexine hydrochloride Standard care RCT Medical staff managing patients with suspected and confirmed COVID-19 N=50
Some concerns
Details

Full description

NCT04304053
Mitja O, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Adults with a recent history of close contact exposure to a PCR confirmed Covid-19 case and absence of Covid-19-like symptoms, as either a healthcare worker,a household contact, a nursing home worker or a nursing home resident. N=2525
Some concerns
Details

Full description

NCT04452318
O'Brien M, N Engl J Med, 2021
Full text
Full text
Commentary
Commentary
Mixed Casirivimab+Imdevimab (REGN-COV2) Placebo RCT Asymptomatic, healthy adult (>18 years of age) and adolescent (>12 to <18 years) household contacts of the first known household member with SARS-CoV-2 infection (defined as the index case) who were RT-qPCR–negative/seronegative and lived with the index case for at least 28 days. N=2475
Low
Details

Full description

NCT04328467
Rajasingham R, medRxiv, 2020
Full text
Commentary
and Commentary
Mixed Hydroxychloroquine 400mg QW Placebo RCT Healthcare workers with ongoing exposure to persons with Covid-19 N=1483
Some concerns
Details

Full description

Hydroxychloroquine 400mg BW Placebo
Hydroxychloroquine 400mg QW Hydroxychloroquine 400mg BW
NCT04318015
Rojas-Serrano J
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT NR N=130
Some concerns
Details

Full description

NCT04446104
Seet R
Full text
Commentary
Mixed Hydroxychloroquine Vitamin C RCT NR N=3358
Some concerns
Details

Full description

Ivermectin Vitamin C
Povidone iodine Vitamin C
Zinc oxide+Vitamin C Vitamin C
NCT04422561
Shouman W, J Clin Diagnostic Res, 2021
Full text
Commentary
No specific funding Ivermectin Standard care RCT Asymptomatic household family members in close contact with cases of COVID-19 diagnosed and confirmed by Reverse Transcription- Polymerase Chain Reaction N=340
High
Details

Full description

NCT04359537
Syed F, CHEER, 2021
Full text
Commentary
Commentary
Private Hydroxychloroquine 400 mg* qweek Placebo RCT NR N=200
Some concerns
Details

Full description

Hydroxychloroquine 400 mg q3week Placebo
Hydroxychloroquine 200 mg q3week Placebo