Living mapping and living systematic review of Covid-19 studies

Studies registered

4711

Registered studies

1525

Randomized Trials (excluding Traditional Chinese Medicine trials)
851 RCTs recruiting

Results

34132

Records screened

33

Randomized Controlled trials

17

Non-randomized studies

227

Observational studies

Over the past week we have screened 1236 records:

  • We have identified and included three RCTs were included, their results are assessed and available on our website. 1) a study evaluating Intravenous Immunoglobulin (IVIG) to standard of care, 2) a study evaluating the prophylactic use of Hydroxychloroquine as comparted to standard of care 3) a study evaluating Hydroxychloroquine with or without Azithromycin
  • Two RCTs are included and pending additional information from authors for data extraction:1) evaluating Methylprednisolone and 2) a study evaluating the safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19
  • Two vaccine trials are under extraction and risk of bias assessment 1) Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older and 2) safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial)
  • Five eligible non-randomized studies are currently being extracted: 3 on corticosteroids and 1 on different treatments (anticoagulation steroids, antivirals, antibiotics and immunomodulators).
  • 15 other observational studies have been added to the list on our website.
  • We also received some supplemental information from authors of previously included RCTs and the data are included and updated in our systematic review.

    We updated the search on ICTRP on July 28, 2020 and identified 77 new trials.

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    Our main activities

    We are performing a living mapping of ongoing research followed by a living network meta-analysis of study results as soon as they are available.

    Our process is summarized in this figure. For more information on our methods see our protocol here.

    This study received funding from the Agence Nationale de la Recherche (ANR).

    We encourage all investigators of Randomized Controlled Trials to contact us as soon as they have results available.