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The COVID-NMA initiative
A living mapping and living systematic review of Covid-19 trials

COVID-NMA is an international research initiative supported by the WHO and Cochrane.

We provide a living mapping of COVID-19 trials. We are also conducting living evidence synthesis on preventive interventions, treatments and vaccines for COVID-19 to assist decision makers.

See the description of our model here and our living review protocol here.

LIVING MAPPING OF TRIALS

(i.e., trials registered on the WHO platform)
Updated weekly

4540
Randomized Trials
1200 RCTs recruiting

3468
RCTs on treatments
(914 recruiting)

381
RCTs on prevention
(79 recruiting)

691
RCTs on vaccines
(207 recruiting)

LIVING SYNTHESIS OF PUBLISHED STUDIES

(include both articles and preprints)
Updated daily

845
Studies (RCTs or Observational studies) with complete data extraction and results
included in our evidence synthesis

563
RCTs on treatments

17
RCTs on prevention

170
RCTs on vaccines

95
observationnal studies on vaccines

meta-COVID

Of note, as of March 1, 2022, the COVID-NMA revised its protocol and reduced its scope.
Only comparisons evaluating antivirals, immunomodulators and COVID-19 vaccines will continue to be updated every two weeks

Perform your own analysis using COVID-NMA data, create and download your forest plots by clicking below:

go to metacovid

Summary of Main Results

Summary of the evidence for pharmacological treatment of hospitalized COVID-19 patients identified up to October 17, 2022 is available below.
As of October 2022, it will be updated every three months.

Summary of Main Results

For earlier editions of the summary of main results, click here

BI-WEEKLY UPDATE

October 21 to November 3. See the update here.

Newsletter

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Excluded Studies

Download CSV file (last update: 2022-09-20).

Retracted Studies

Download CSV file (last update: 2022-09-15).

This work received some funding from the Agence Nationale de la Recherche (ANR), the World Health Organization (WHO), Cochrane France, Center of Research in Epidemiology and StatisticS (CRESS), Centre d’Epidémiologie Clinique (GHU Cochin, Hôtel Dieu), the French Ministry of Higher Education and Research, the French Ministry of Health, Assistance Publique Hôpitaux de Paris (APHP), Université de Paris Cité, Centre national de la recherche scientifique (CNRS), the Federal Ministry of Education and Research (Germany), and VACCELERATE project (funded by the European Union's Horizon 2020 Research and Innovation Programme under agreement No. 101037867).