Living mapping and living systematic review of Covid-19 studies
Randomized Trials (excluding Traditional Chinese Medicine trials)
851 RCTs recruiting
Randomized Controlled trials
Over the past week we have screened 1236 records:
We also received some supplemental information from authors of previously included RCTs and the data are included and updated in our systematic review.
We updated the search on ICTRP on July 28, 2020 and identified 77 new trials.
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Our main activities
We are performing a living mapping of ongoing research followed by a living network meta-analysis of study results as soon as they are available.
- We are searching and extracting data from RCTs registered in ICTRP once a week (the WHO updates its registry every Wednesday).
- We are updating the living mapping and evidence synthesis on our website once a week (every Friday).
- A living mapping of studies registered is now available: it is possible to filter studies by type of pharmacological treatment, registration date, study aim, severity scale. An interactive map showing the clinical trials per country is also available. This data visualization was developed by a team from the LIRIS laboratory (CNRS/École Centrale de Lyon) in the context of a large collaboration with the CNRS. Several other teams from CNRS have offered their help for this project to contribute to the fight against Covid-19. As a result, more graphs and tables are currently being developed and will be soon available on our website.
- We are screening electronic databases (PubMed/Chinarxiv and MedRxiv) every day to identify results of RCTs and non-randomized-studies.
- We are collecting data from all RCTs identified. The main characteristics of trials, including a complete description of the assessment of each risk of bias domain with support for judgement and forest plots are available here. The Evidence profile and Summary of Findings (SoF) tables for most of the comparisons are also available online and the missing ones are currently being designed.
- We are contacting all investigators of ongoing trials to obtain the trial protocol and results as soon as available.
- Several databases of the reference list for modeling studies, observational studies, RCTs and non-RCT studies and studies we excluded from our systematic review are available online . Users of datasets published by the Covid-NMA project are required to acknowledge the source with an appropriate citation. We recommend using the following format: Authors. (Year). Dataset title [Data set]. Repository. DOI
This study received funding from the Agence Nationale de la Recherche (ANR).