Covid-19 living Data

Pharmacologic treatments for covid-19 patients

Analyses are updated every Friday

Methods

Treatment comparisons

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Access the forest plots for the 283 treatment comparisons .

Anti-virals (84 comparisons) update new

Other antimicrobials (antibiotics, antimalarials, antiparasitics) (66 comparisons) update new

NSAIDs and Anti-inflammatories (9 comparisons) update new

Kinase inhibitor (14 comparisons) update new

Corticosteroids (15 comparisons) update new

Monoclonal antibodies (51 comparisons) update new

Immunosupressant (4 comparisons) update new

Convalescent plasma (3 comparisons) update new

Antithrombotic (antiplatelet, anticoagulant, thrombolytic drug) (14 comparisons) update new

Other Advanced therapy medicinal products (ATMP) (7 comparisons) update new

Others (78 comparisons) update new

General characteristics of primary studies

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Trial	Funding	Comparisons		Design	Participants	Sample size	Overall risk of bias Highest assessment	Full description
		Treatment 1	Treatment 2
N/A Dengiz E, Med Gas Res (2021) Full text Commentary	Private	Oxygen-Ozone	Standard care	RCT	Patients with confirmed COVID-19 (symptomatic, unclear severity) admitted to a single center in Turkey.	N=30	Some concerns Details	Full description
NCT04221737 Ibarra-Estrada MA, Crit Care Med (2021) Full text Commentary	Not reported/unclear	APR ventilation	LTV ventilation	RCT	Patients with confirmed COVID-19 (critical) admitted to a single center in Mexico.	N=101	Some concerns Details	Full description
NCT04426695 Somersan-Karakaya S, medRxiv (2021) Full text Commentary Commentary	Mixed	REGN-COV2 2400mg REGN-COV2 800mg	Placebo	RCT	Patients with confirmed COVID-19 (mild-moderate) admitted to 103 centers in USA, Brazil, Chile, Mexico, Moldova, and Romania	N=1364	Some concerns Details	Full description
NCT04435795 CONTAIN Ezer N, BMJ (2021) Full text Commentary Commentary	Mixed	Ciclesonide	Placebo	RCT	Outpatients with confirmed COVID-19 (mild, symptomatic) treated by multiple centers in Canada	N=215	Some concerns Details	Full description
CTRI/2020/09/027903 Parikh D, medRxiv (2021) Full text Commentary Commentary	Private	C-IVIG	Standard care	RCT	Patients with confirmed COVID-19 (moderate-severe) admitted to 7 centers in India.	N=60	Some concerns Details	Full description
NCT04581811 Page DB, Ann Am Thorac Soc (2021) Full text Commentary	No specific funding	Prolonged Proning	Prone position	RCT	Patients with confirmed COVID-19 (critical) admitted to a single center in USA	N=52	Some concerns Details	Full description
NCT04427501 Dougan M, Clin Infect Dis (2021) Full text Commentary Commentary	Private	LY-CoV555+LY-CoV016	Placebo	RCT	Outpatients with confirmed COVID-19 (mild) treated at multiple centers in the USA and Puerto Rico.	N=782	Low Details	Full description
IRCT20210614051574N5 Haghighi S, SSRN (2021) Full text Commentary	Mixed	Thalidomide	Standard care	RCT	Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Iran.	N=50	Some concerns Details	Full description
NCT04330638; EudraCT2020-001500-41 COV-AID Declercq J, Lancet Respir Med (2021) Full text Commentary Commentary (21)00405-7	Public/non profit	ANA Tocilizumab Siltuximab ANA ANA Tocilizumab Anakinra + Tocilizumab	Standard care Standard care Standard care Tocilizumab Siltuximab Siltuximab Standard care	RCT	Patients with confirmed COVID-19 (moderate-critical) admitted to 16 centers in Belgium.	N=342	Some concerns Details	Full description
NCT04604327 Marcos M, Thromb Haemost (2021) Full text Commentary Commentary	Mixed	Therap AC	Prophylactic AC	RCT	Patients with suspected or confirmed COVID-19 (mild-moderate) admitted to 5 centers in Spain.	N=0	High Details	Full description