Note: The risk of bias by domain corresponds to the highest risk of bias among outcomes by domain.
The overall risk of bias corresponds to the overall highest risk of bias assessed among outcomes.
| Bias | Author's judgement | Support for judgement |
| Randomization |
Some concerns |
Quote: “A single-center, randomized, prospective study”
Comment: No information on sequence generation and allocation concealment |
| Deviations from intervention |
Some concerns |
Comment: No information on blinding.
No participant cross-over. No information on administration of co-interventions of interest: antivirals, corticosteroids and biologics. Hence, no information on whether deviations arose because of the trial context. Our analysis for the binary outcome is an intention-to-treat analysis. This method was considered appropriate to estimate the effect of assignment to intervention. br/>Risk assessed to be some concerns for the outcomes: Incidence of viral negative conversion (D7) |
| Missing outcome data |
Some concerns |
Comment: 60 patients randomized; 60 patients analyzed.
Data available for all or nearly all participants randomized. Risk assessed to be low for the outcome: Incidence of viral negative conversion. Risk assessed to be low for the outcomes:Incidence of viral negative conversion (D7) |
| Measurement of the outcome |
Low |
Comment: No information on blinding.
Viral negative conversion is an observer-reported outcome not involving judgement. Risk assessed to be low for the outcome: Incidence of viral negative conversion. |
| Selection of the reported results |
Some concerns |
Comment: Trial registry, protocol and statistical analysis plan were not available.
No information on whether the result was selected from multiple outcome measurements or analyses of the data. No information on whether the trial was analyzed as pre-specified. Risk assessed to be some concerns for the outcome: Incidence of viral negative conversion (D7). |
| Overall risk of bias |
Some concerns |