Pharmacologic treatments for covid-19 patients

Analyses are updated every Friday

Methods

Treatment comparisons

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Access the forest plots for the 13 treatment comparisons .

    Anti-virals (1 comparisons)

    Other antimicrobials (antibiotics, antimalarials, antiparasitics) (5 comparisons)

    NSAIDs and Anti-inflammatories (1 comparisons)

    Corticosteroids (1 comparisons)

    Monoclonal antibodies (2 comparisons)

    Convalescent plasma (1 comparisons)

General characteristics of primary studies

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04353336
Abd-Elsalam S, Am J Trop Med Hyg, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild-severe) admitted to three university hospitals in Egypt. N=194
Some concerns
Details

Full description

NCT04403555
Abd-Elsalam S, J Med Virol, 2021
Full text
Commentary
Not reported/unclear Ivermectin Standard care RCT Patients with confirmed COVID-19 admitted to 2 centers in Egypt N=164
Some concerns
Details

Full description

NCT04315948; EudraCT
Ader F, DisCoVeRy, Clin Microbiol Infect, 2021
Full text
Commentary
; Commentary
Mixed Lopinavir-Ritonavir Lopinavir-Ritonavir+Interferon beta-1a RCT Patients with confirmed COVID-19 (mild-critical) admitted to 32 centers in France and Luxembourg N=603
Some concerns
Details

Full description

Lopinavir-Ritonavir Hydroxychloroquine
Lopinavir-Ritonavir Standard care
Lopinavir-Ritonavir+Interferon beta-1a Hydroxychloroquine
Lopinavir-Ritonavir+Interferon beta-1a Standard care
Hydroxychloroquine Standard care
NCT04315948, EudraCT2020-000936-23
Ader F, SSRN, 2021
Full text
Commentary
Public/non profit Remdesivir Standard care RCT Patients with confirmed COVID-19 (mild-critical) admitted to 48 centers in France (39), Belgium (3), Portugal (2), Austria (3), and Luxembourg (1). N=857
Some concerns
Details

Full description

CTRI/2020/04/024775
PLACID
Agarwal A, BMJ, 2020
Full text
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (mild to severe) admitted to 39 centers in India. N=464
Some concerns
Details

Full description

new
NCT04407130
Ahmed S, 2020
Full text
Commentary
Private Ivermectin+Doxycycline Placebo RCT Patients with confirmed COVID-19 (mild) admitted to hospital in Bangladesh. N=72
Some concerns
Details

Full description

Ivermectin+Doxycycline Ivermectin
Ivermectin Placebo
NCT04356534
AlQahtani M, Sci Rep, 2021
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 2 centers in Bahrain N=40
Some concerns
Details

Full description

NCT04329923
Amaravadi R, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Outpatients with confirmed COVID-19 (symptomatic, mild ) treated by a single center in USA N=34
Some concerns
Details

Full description

NCT02735707
Angus DC, JAMA, 2020
Full text
Commentary
Public/non profit Fixed-dose hydrocortisone Standard care RCT Patients with COVID-19 (severe-critical) admitted to 121 centers in 8 countries N=251
Some concerns
Details

Full description

NCT04716569
Aref ZF, Int J Nanomed, 2021
Full text
Commentary
Public/non profit Ivermectin Standard care RCT Outpatients with confirmed COVID-19 (mild, symptomatic) treated at a single center in Egypt. N=114
Some concerns
Details

Full description

NCT04345523
Avendano-Sola C, medRxiv, 2020
Full text
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to 14 centers in Spain N=81
Some concerns
Details

Full description

NCT04321616
Barratt-Due A, SSRN, 2021
Full text
Commentary
Commentary
Mixed Remdesivir Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to 23 centers in Norway N=101
Low
Details

Full description

NCT04321616
Barratt-Due A, SSRN, 2021
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to 23 centers in Norway N=108
Some concerns
Details

Full description

new
NCT04348656
Begin P, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 72 centers in Canada, USA and Brazil. N=940
Some concerns
Details

Full description

NCT04280705
Beigel JH, N Engl J Med, 2020
Full text
Commentary
Public/non profit Remdesivir Placebo RCT Patients with confirmed COVID-19 (mild-critical) admitted to 60 centers in 10 countries N=1062
Some concerns
Details

Full description

NCT04391127
Beltran-Gonzalez J, 2021
Full text
Commentary
Commentary
Public/non profit Ivermectin Placebo RCT Patients with suspected or confirmed COVID-19 (moderate/severe) admitted to a single center in Mexico N=106
Some concerns
Details

Full description

Hydroxychloroquine Placebo
Ivermectin Hydroxychloroquine
NCT04344535
Bennett-Guerrero, E, Crit Care Med, 2021
Full text
Commentary
Commentary
Private Convalescent plasma Standard plasma RCT Patients with confirmed COVID-19 (mild-critical) admitted to a single center in USA. N=74
Some concerns
Details

Full description

NCT04429711
Biber A, medRxiv, 2021
Full text
Commentary
Commentary
No specific funding Ivermectin Placebo RCT Outpatients with confirmed COVID-19 (mild) treated by multiple centers in Israel N=116
Some concerns
Details

Full description

NCT04860284
Byakika-Kibwika P, Research square , 2021
Full text
Commentary
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Outpatients with confirmed COVID-19 (asymptomatic and symptomatic, mild) isolated at a single center in Uganda. N=105
Some concerns
Details

Full description

NCT04322123
Cavalcanti AB, N Engl J Med, 2020
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with suspected or confirmed COVID-19 (mild-moderate) admitted to 55 centers in Brazil N=667
Some concerns
Details

Full description

Hydroxychloroquine + Azithromycin Standard care
Hydroxychloroquine + Azithromycin Hydroxychloroquine
NCT04390022
Chaccour C, EClinicalMedicine, 2021
Full text
Commentary
Mixed Ivermectin Placebo RCT Outpatients with confirmed COVID-19 (mild) attending the emergency room at a single center in Spain N=24
Some concerns
Details

Full description

NCT04784481
Chahla R, Research Square, 2021
Full text
Commentary
Public/non profit Ivermectin Standard care RCT Outpatients with confirmed COVID-19 (mild) treated by multiple centers in Argentina. N=254
Some concerns
Details

Full description

NCT04384380
Chen CP, Plos one, 2020
Full text
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 11 centers in Taiwan N=33
Some concerns
Details

Full description

NCT04261517
Chen J, Journal of Zhejiang , 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to a single center in China N=30
High
Details

Full description

ChiCTR2000030054
Chen L, medRxiv, 2020
Full text
Commentary
Public Hydroxychloroquine Chloroquine RCT Patients with confirmed COVID-19 (mild, moderate) admitted to a single center in China N=67
High
Details

Full description

Chloroquine Standard care
Hydroxychloroquine Standard care
ChiCTR2000029559
Chen Z, medRxiv, 2020
Full text
Commentary
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to a single center in China. N=62
Some concerns
Details

Full description

NCT04326790
Deftereos S, JAMA, 2020
Full text
Commentary
Private Colchicine Standard care RCT Patients with COVID-19 (moderate-severe) admitted to 16 centers in Greece. N=110
Some concerns
Details

Full description

NCT02517489
Dequin P-F, JAMA, 2020
Full text
Commentary
Public/non profit Hydrocortisone Placebo RCT Patients with COVID-19 (severe-critical) admitted to 9 centers in France N=149
Some concerns
Details

Full description

new
NCT04861298
Di Pierro F, Int J Gen Med, 2021
Full text
Commentary
Private Quercetin Standard care RCT Outpatients with confirmed COVID-19 (mild) treated at a single center in Pakistan N=42
Some concerns
Details

Full description

NCT04325893
Dubee V, Clin Microbiol Infec, 2021
Full text
Commentary
Commentary
Public/non profit Hydroxychloroquine Placebo RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 34 centers in France and Monaco. N=250
Some concerns
Details

Full description

IRCT20200404046947N1
Edalatifard M, Eur Respir J, 2020
Full text
Commentary
Public/non profit Intravenous Methylprednisolone pulse Standard care RCT Patients with confirmed COVID-19 (severe) admitted to two centers in Iran N=68
Some concerns
Details

Full description

NCT02735707
Estcourt L, medRxiv, 2021
Full text
Commentary
Mixed Standard care Convalescent plasma RCT Patients with confirmed COVID-19 (severe-critical) admitted to 129 centers in Australia, Canada, UK, USA N=2000
Low
Details

Full description

IRCT20200406046963N1
Farahani R, Research Square, 2020
Full text
Commentary
Public/non profit Intravenous Methylprednisolone pulse+Prednisolone Standard care RCT Patients with COVID-19 (severe) admitted to a single center in Iran N=29 N/A

Full description

RBR-8h7q82
Galan L ,Pathog Glob Health, 2021
Full text
Commentary
Public/non profit Ivermectin Hydroxychloroquine RCT Patients with serology or RT-PCR confirmed COVID-19 (moderate-critical) admitted to a single center in Brazil. N=168 N/A

Full description

Ivermectin Chloroquine
Hydroxychloroquine Chloroquine
NCT04342182
Gharbharan A, Nat Commun, 2021
Full text
Commentary
Mixed Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 14 centers in the Netherlands N=86
Some concerns
Details

Full description

new
N/A
Hamed D M, J Infect Public Health, 2021
Full text
Commentary
No specific funding Methylprednisolone Methylprednisolone +Tocilizumab RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Dubai. N=49
Some concerns
Details

Full description

NCT04591600
Hashim A, medRxiv, 2020
Full text
Commentary
Commentary
Public/non profit Ivermectin+Doxycycline Standard care RCT Outpatients and inpatients with COVID-19 (unclear severity) treated at 2 centers in Iraq N=140
High
Details

Full description

NCT04315896
Hernandez-Cardenas C, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Patients with RT-PCR confirmed COVID-19 (severe-critical) admitted to 3 centers in Mexico N=214
Some concerns
Details

Full description

NCT04381936; EudraCT 2020-001113-21; ISRCTN5018967
Horby P, Lancet, 2021
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with suspected or confirmed COVID-19 (mild-moderate-severe-critical) admitted to 177 centers in the UK. N=11558
Some concerns
Details

Full description

NCT04381936 ; ISRCTN50189673
Horby P, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Colchicine Standard care RCT Patients with suspected or confirmed COVID-19 (mild-critical) admitted to 177 centers in the UK, 2 centers in Indonesia, and 2 centers in Nepal N=11340
Some concerns
Details

Full description

NCT04381936
Horby P, N Engl J Med, 2020
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild-critical) admitted to 176 centers in the UK N=4716
Some concerns
Details

Full description

NCT04381936
RECOVERY Trial
Horby P, N Engl J Med, 2021
Full text
Commentary
Mixed Dexamethasone Standard care RCT Patients with suspected and confirmed COVID-19 (mild-moderate-critical) admitted to 176 centers in the UK N=6425
Some concerns
Details

Full description

Forest plot
(sub group)
IRCT20151227025726N17
Jamaati H, Eur J Pharmacol, 2021
Full text
Commentary
Public/non profit Dexamethasone Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran N=50
Some concerns
Details

Full description

NCT04491994
Kamran S M, Cureus, 2021
Full text
Commentary
Commentary
No specific funding Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (mild) admitted to a single center in Pakistan N=540
High
Details

Full description

NCT04739410
Khan Chachar AZ, Int J Sci, 2020
Full text
Commentary
No specific funding Ivermectin Standard care RCT Outpatients with confirmed COVID-19 (symptomatic-mild) treated at a single center in Pakistan N=50
High
Details

Full description

CTRI/2020/08/027225
Kirti R, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Ivermectin Placebo RCT Patients with COVID-19 (mild-severe) admitted to a single center in India N=115
High
Details

Full description

N/A
Kishoria N, PIJR, 2020
Full text
Commentary
Not reported/unclear Ivermectin Standard care RCT Patients with confirmed COVID-19 (mild/asymptomatic) admitted to a single center in India. N=32
Some concerns
Details

Full description

NCT04433910 ; EudraCT 2020-001310-38
Koerper S, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (mild-critical) admitted to 13 centers in Germany. N=105
Some concerns
Details

Full description

NCT04381884
Krolewiecki A, EClinicalMedicine, 2021
Full text
00239-X/fulltext Commentary
Commentary
Mixed Ivermectin Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 4 centers in Argentina N=45
Some concerns
Details

Full description

ChiCTR2000029757
Li L, JAMA, 2020
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with COVID-19 (severe to critical) admitted to 7 centers in China N=103
Some concerns
Details

Full description

NCT04479163
Libster R, N Engl J Med, 2021
Full text
Commentary
Public/non profit Convalescent plasma Placebo RCT Patients with confirmed COVID-19 (mild) admitted to multiple centers in Argentina N=160
Some concerns
Details

Full description

RBR-8jyhxh
Lopes MIF, RMD Open, 2021
Full text
Commentary
Public/non profit Colchicine Placebo RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Brazil N=75
Some concerns
Details

Full description

NCT04405843
Lopez-Medina E, JAMA, 2021
Full text
Commentary
Commentary
Mixed Ivermectin Placebo RCT Outpatients with confirmed COVID-19 (mild) treated by a single center in Colombia N=476
Some concerns
Details

Full description

NCT04316377
Lyngbakken MN, Nature, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (mild-severe) admitted to a single center in Norway N=53
High
Details

Full description

N/A
Mahajan L, Indian J Anaesth, 2021
Full text
Commentary
No specific funding Remdesivir Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in India. N=82
High
Details

Full description

NCT04523831
Mahmud R, J Int Med Res, 2021
Full text
Commentary
No specific funding Ivermectin+Doxycycline Placebo RCT Outpatients and inpatients with confirmed COVID-19 (ambulatory-mild-moderate) admitted to a single center in Bangladesh N=400
Some concerns
Details

Full description

NCT04304053
Mitja O, Clin Infect Dis, 2020
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Outpatients with COVID-19 (mild) in an ambulatory setting in Spain N=353
Some concerns
Details

Full description

CTRI/2020/06/026001
Mohan A, 2021
Full text
Commentary
Mixed Ivermectin 12 mg Placebo RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in India N=152
Some concerns
Details

Full description

Ivermectin 24 mg Placebo
Ivermectin 12 mg Ivermectin 24 mg
new
NCT04348305
Munch MW, Acta Anaesthesiol Scand, 2021
Full text
Commentary
Mixed Hydrocortisone Placebo RCT Patients with confirmed COVID-19 (severe/critical) admitted to 12 centers in Denmark N=30
Low
Details

Full description

IRCT20200408046987N1
Niaee MS, 2020
Full text
Commentary
Commentary
Mixed Ivermectin Once-off Standard care RCT Patients with CT or PCR confirmed COVID-19 (unclear severity) admitted to 5 centers in Iran. N=180
Some concerns
Details

Full description

Ivermectin Once-off Placebo
Ivermectin 3-day LD Standard care
Ivermectin 3-day LD Placebo
Ivermectin 1-day BDS Standard care
Ivermectin 1-day BDS Placebo
Ivermectin 3-day HD Standard care
Ivermectin 3-day HD Placebo
NCT04359810
O Donnell M, J Clin Invest, 2021
Full text
Commentary
Commentary
Not reported/unclear Convalescent plasma Control plasma RCT Patients with confirmed COVID-19 (mild-critical) admitted to 5 centers in Brazil and USA N=223
Low
Details

Full description

new
NCT04452318
O'Brien M, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Casirivimab+imdevimab (REGN-COV02) Placebo RCT NR N=4950
Some concerns
Details

Full description

NCT04646109
Okumus N, BMC Infectious Disea, 2021
Full text
Commentary
Commentary
Public/non profit Ivermectin Standard care RCT Patients with confirmed COVID-19 (severe) admitted to four centers in Turkey N=66
High
Details

Full description

NCT04349592
Omrani A, Q-PROTECT, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine+Azithromycin Placebo RCT Outpatients with confirmed COVID-19 (mild) treated by 2 centers in Qatar N=456
Some concerns
Details

Full description

Hydroxychloroquine+Azithromycin Hydroxychloroquine
Hydroxychloroquine Placebo
ISRCTN83971151; NCT04315948
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Remdesivir Standard care RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries N=5475
Low
Details

Full description

ISRCTN83971151; NCT04315948
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries N=1863
Low
Details

Full description

NCT04348305
Perner A, Unpublished, 2020
Mixed Hydrocortisone Placebo RCT Patients with confirmed COVID-19 (severe-critical) admitted to 19 centers in Denmark. N=29
Low
Details

Full description

N/A
Podder C, IMC J Med Sci, 2020
Full text
No specific funding Ivermectin Standard care RCT Outpatients with confirmed COVID-19 (mild-moderate) treated at a single center in Bangladesh N=*

Details

Full description

IRCT20200310046736N1
Pouladzadeh M, Intern Emerg Med, 2021
Full text
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe-critical) admitted to a single center in Iran N=62
Some concerns
Details

Full description

NCT04343729
Prado Jeronimo CM, Clin Infect Dis, 2020
Full text
Commentary
Public/non profit Methylprednisolone Placebo RCT Patients with COVID-19 (moderate-critical) admitted to a single center in Brazil N=416
High
Details

Full description

N/A
Rasheed A, Le Infezioni in Medicina, 2020
Full text
Public/non profit Convalescent plasma Standard care RCT Patients with COVID-19 (severe) admitted to 3 centers in Iraq. N=49 N/A

Full description

CTRI/2020/05/025209
Ray Y, medRxiv, 2020
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in India N=80
High
Details

Full description

NCT04403100
Reis G, TOGETHER, 2021
Full text
Commentary
Commentary
Public/non profit Lopinavir-Ritonavir Placebo RCT Outpatients with confirmed COVID-19 (mild) treated at local public health facilities in 10 cities in Brazil N=685
Some concerns
Details

Full description

Lopinavir-Ritonavir Hydroxychloroquine
Hydroxychloroquine Placebo
new
Saudi Clinical Trial Registry (SCTR): 20061006
Sabico S, Nutrients, 2021
Full text
Commentary
Mixed Vitamin D 5000 IU Vitamin D 1000 IU RCT Patients with confirmed COVID-19 (mild outpatients or hospitalised mild-moderate) admitted or treated by 2 centers in Saudi Arabia N=73
Some concerns
Details

Full description

IRCT20200418047126N1
Salehzadeh F, Research Square, 2020
Full text
Commentary
Public/non profit Colchicine Placebo RCT Patients with confirmed COVID-19 (unclear severity) admitted to a single center in Iran N=100
Some concerns
Details

Full description

NCT04530370
Salman OH, Egypt J Anaesth, 2020
Full text
Commentary
Not reported/unclear Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Egypt N=30
Some concerns
Details

Full description

ChiCTR2000033627
Samaha A,, Viruses, 2021
Full text
Commentary
No specific funding Ivermectin Standard care RCT Outpatients with confirmed COVID-19 (asymptomatic-mild) recruited through testing centers in Lebanon. N=100
Some concerns
Details

Full description

new
NCT04329611
Schwartz I, CMAJ Open, 2021
Full text
Commentary
Mixed Hydroxychloroquine Placebo RCT Outpatients with confirmed COVID-19 (mild, symptomatic) treated in the community by the public health system in Canada N=148
Some concerns
Details

Full description

NCT04332991
Self W, JAMA, 2020
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Patients with COVID-19 confirmed (mild-critical) admitted to 34 centers in the USA N=479
Some concerns
Details

Full description

NCT04392713
Shah Bukhari K H, medRxiv, 2021
Full text
Commentary
Commentary
Not reported/unclear Ivermectin Standard care RCT Patients with confirmed COVID-19 (mild) admitted to a single center in Pakistan N=100
High
Details

Full description

IRCT20111224008507N3
Shahbaznejad L, Clin Ther, 2021
Full text
Commentary
No specific funding Ivermectin Standard care RCT Patients with suspected or confirmed COVID-19 (moderate-critical) admitted to 2 centers in Iran. N=73
Some concerns
Details

Full description

NCT04383535
Simonovich VA, N Engl J Med, 2020
Full text
Commentary
Mixed Convalescent plasma Placebo RCT Patients with confirmed COVID-19 (severe) admitted to 12 centers in Argentina N=334
Some concerns
Details

Full description

NCT04308668
Skipper CP, Ann Intern Med, 2020
Full text
Commentary
Private Hydroxychloroquine Placebo RCT Outpatients with suspected or confirmed COVID-19 (symptomatic, mild) with high-risk exposure within 4 days of symptom onset N=491
Some concerns
Details

Full description

new
NCT04341038; EudraCT 2020-001445-39
Solanich X, Front Med, 2021
Full text
Commentary
Commentary
Public/non profit Methylprednisolone pulse+Tacrolimus Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Spain N=55
Some concerns
Details

Full description

NCT04292730
Spinner CD, JAMA, 2020
Full text
Commentary
Private Remdesivir 5 days Standard care RCT Patients with COVID-19 (mild-severe) admitted to 105 centers in the USA, Europe and Asia N=596
Some concerns
Details

Full description

Remdesivir 10 days Standard care
Remdesivir 5 days Remdesivir 10 days
ChiCTR2000029868
Tang W, BMJ, 2020
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild, moderate and severe) admitted to 16 centers in China N=150
Some concerns
Details

Full description

NCT04273321
Tang X, Respiration, 2021
Full text
Commentary
Public/non profit Methylprednisolone Placebo RCT Patients with confirmed COVID-19 (moderate/severe) admitted to 7 centers in China. N=86
Some concerns
Details

Full description

NCT04322682
Tardif JC, Lancet Respir Med, 2021
Full text
Commentary
Commentary
Mixed Colchicine Placebo RCT Outpatients with suspected or confirmed COVID-19 (mild) at multiple centers in Brazil, Canada, Greece, South Africa, Spain, USA N=*

Details

Full description

NCT04327401
Tomazini BM, JAMA, 2020
Full text
Commentary
Mixed Dexamethasone Standard care RCT Patients with suspected or confirmed COVID-19 (critical) admitted to 41 centers in Brazil N=299
Some concerns
Details

Full description

NCT04369742
Ulrich RJ, Open Forum Infect Di, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Placebo RCT Patients with confirmed COVID-19 (mild-severe) admitted to 5 centers in USA N=128
Some concerns
Details

Full description

NCT04529525
Vallejos J, BMC Infect Dis, 2021
Full text
Commentary
No specific funding Ivermectin Placebo RCT Outpatients with confirmed COVID-19 (asymptomatic-mild) treated by a single center in Argentina N=501
Low
Details

Full description

NCT04325061
Villar J, Unpublished, 2020
Public/non profit Dexamethasone Standard care RCT Patients with confirmed COVID-19 (critical) admitted 14 centers in Spain N=19
Low
Details

Full description

NCT04257656
Wang Y, Lancet, 2020
Full text
Commentary
Mixed Remdesivir Placebo RCT Patients with confirmed COVID-19 (severe) admitted to 10 centers in China N=237
Some concerns
Details

Full description