Pharmacologic treatments for covid-19 patients

Below you can access forest plots for all the treatment comparisons as well as the general characteristics of each trial with risk of bias assessment.

Analyses are updated every Friday.

Of note, the search “display new or updated results” may identify comparisons not tagged as ‘updated’ when a trial related to this comparison has been identified or updated and is reported in the table but is not yet included in the analysis.

More details about outcomes and Disease severity

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Create and download your forest plots with the most up-to-date data here Forest plots

Treatment comparisons

Access the forest plots for the 163 treatment comparisons .

    Anti-virals (48 comparisons)

    Other antimicrobials (antibiotics, antimalarials, antiparasitics) (31 comparisons)

    NSAIDs and Anti-inflammatories (2 comparisons)

    Kinase inhibitor (6 comparisons)

    Corticosteroids (4 comparisons)

    Monoclonal antibodies (11 comparisons)

    Immunosupressant (2 comparisons)

    Convalescent plasma (2 comparisons)

    Antithrombotic (antiplatelet, anticoagulant, thrombolytic drug) (3 comparisons)

    Other Advanced therapy medicinal products (ATMP) (3 comparisons)

    Others (35 comparisons)

General characteristics of primary studies

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
IRCT20200328046886N1
Abbaspour Kasgari H, J Antimicrob Chemoth, 2020
Full text
Commentary
Public/non profit SOF/DCV+RBV Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to a single center in Iran. N=48
Some concerns
Details

Full description

NCT04353336
Abd-Elsalam S, Am J Trop Med Hyg, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild-severe) admitted to three university hospitals in Egypt. N=194
Some concerns
Details

Full description

NCT04447534
Abd-Elsalam S, Biol Trace Elem Res, 2020
Full text
Commentary
Hydroxychloroquine+Zinc Hydroxychloroquine RCT Patients with confirmed COVID-19 (mild-critical) admitted to 3 centers in Egypt N=191
Some concerns
Details

Full description

NCT04315948; EudraCT
Ader F, DisCoVeRy, medRxiv, 2021
Full text
Commentary
; Commentary
Mixed Lopinavir-Ritonavir Lopinavir-Ritonavir+Interferon beta-1a RCT Patients with confirmed COVID-19 (mild-critical) admitted to 32 centers in France and Luxembourg N=603
Some concerns
Details

Full description

Lopinavir-Ritonavir Hydroxychloroquine
Lopinavir-Ritonavir Standard care
Lopinavir-Ritonavir+Interferon beta-1a Hydroxychloroquine
Lopinavir-Ritonavir+Interferon beta-1a Standard care
Hydroxychloroquine Standard care
CTRI/2020/04/024775
PLACID
Agarwal A, BMJ, 2020
Full text
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (mild to severe) admitted to 39 centers in India. N=464
High
Details

Full description

NCT04407130
Ahmed S,Int J Infect Dis,2020
Full text
Commentary
Private Ivermectin+Doxycycline Placebo RCT Patients with confirmed COVID-19 (mild) admitted to hospital in Bangladesh. N=72
Some concerns
Details

Full description

Ivermectin+Doxycycline Ivermectin
Ivermectin Placebo
IRCT20200328046882N1
Alavi-moghaddam M, SSRN, 2021
Full text
Commentary
Public/non profit Sofosbuvir Lopinavir-Ritonavir+Interferon beta-1a RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran N=57
Some concerns
Details

Full description

NCT04356534
AlQahtani M, medRxiv, 2020
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 2 centers in Bahrain N=40
Some concerns
Details

Full description

NCT04573153
Altay O, medRxiv, 2020
Full text
Commentary
Private Combined metabolic cofactor supplementation Placebo RCT Patients with confirmed COVID-19 (mild) treated at a single center in Turkey N=93
Some concerns
Details

Full description

NCT04329923
Amaravadi R, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Outpatients with confirmed COVID-19 (symptomatic, mild ) treated by a single center in USA N=34
Some concerns
Details

Full description

NCT02735707
Angus DC, JAMA, 2020
Full text
Commentary
Public/non profit Fixed-dose hydrocortisone Standard care RCT Patients with COVID-19 (severe-critical) admitted to 121 centers in 8 countries N=251
Some concerns
Details

Full description

IRCT20200317046797N4
Ansarin K, BioImpacts, 2020
Full text
Commentary
Public/non profit Bromhexine Standard care RCT Patients with COVID-19 (unclear severity) at a single center in Iran N=78
Some concerns
Details

Full description

NCT04366089
Araimo F , J Med Virol, 2020
Full text
Commentary
No specific funding Oxygen-Ozone+Probiotic Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Italy N=28
High
Details

Full description

NCT04345523
Avendano-Sola C, medRxiv, 2020
Full text
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to 14 centers in Spain N=81
Some concerns
Details

Full description

ISRCTN40302986
Babalola OE, IVERCOVID, medRxiv, 2021
Full text
Commentary
Commentary
Private Ivermectin 6mg Ivermectin 12mg RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in Nigeria N=62
Some concerns
Details

Full description

Ivermectin 6mg Lopinavir-Ritonavir
Ivermectin 12mg Lopinavir-Ritonavir
NCT04346446
Bajpai M, medRxiv, 2020
Full text
Commentary
and Commentary
No specific funding Convalescent plasma Fresh frozen plasma RCT Patients with confirmed COVID-19 (severe) admitted to a single center in India N=31
Some concerns
Details

Full description

NCT04375098
Balcells M, PLoS Med, 2021
Full text
Commentary
Public/non profit Early Convalescent plasma Late Convalescent plasma RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single centre in Chile. N=58
Some concerns
Details

Full description

NCT04542694
Balykova L, Infektsionnye bolezn, 2020
Full text
Commentary
Private Favipiravir Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to 5 centers in Russia N=200
Some concerns
Details

Full description

NCT04321616
Barratt-Due A, SSRN, 2021
Full text
Commentary
Commentary
Mixed Remdesivir Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to 23 centers in Norway N=101
Low
Details

Full description

NCT04321616
Barratt-Due A, SSRN, 2021
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to 23 centers in Norway N=108
Some concerns
Details

Full description

NCT04280705
Beigel JH, N Engl J Med, 2020
Full text
Commentary
Public/non profit Remdesivir Placebo RCT Patients with confirmed COVID-19 (mild-critical) admitted to 60 centers in 10 countries N=1062
Some concerns
Details

Full description

NCT04391127
Beltran-Gonzalez J, 2021
Full text
Commentary
Commentary
Public/non profit Ivermectin Placebo RCT Patients with suspected or confirmed COVID-19 (moderate/severe) admitted to a single center in Mexico N=106
Some concerns
Details

Full description

Hydroxychloroquine Placebo
Ivermectin Hydroxychloroquine
NCT04323527
Borba MGS, JAMA Netw Open, 2020
Full text
Commentary
Public/non profit Chloroquine Chloroquine RCT Patients with Severe/Critical respiratory syndrome secondary to SARS-CoV-2 infection treated in a single center in Brazil. N=80
Low
Details

Full description

Forest plots
N/A
Borges M, Revista Universidad, Ciencia y Tecnologia, 2021
Full text
Commentary
Not reported/unclear Methisoprinol Standard care RCT Outpatients with confirmed COVID-19 (symptomatic) treated at home in Ecuador N=60 N/A

Full description

NCT04329832
Brown SM, Ann Am Thorac Soc, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Azithromycin RCT Patients with confirmed COVID-19 (mild-critical) admitted to 13 centers in the USA N=85
Some concerns
Details

Full description

ISRCTN86534580 ; EudraCT 2020-001209-22
Butler C, Lancet , 2021
Full text
Commentary
Public/non profit Azithromycin Standard care RCT Outpatients with suspected or confirmed COVID-19 (mild) recruited in the community in the UK N=540
High
Details

Full description

NCT04729491
Cadegiani F,, Cureus, 2021
Full text
Commentary
Commentary
Commentary
No specific funding Dutasteride Placebo RCT Outpatients with confirmed COVID-19 (mild) treated by 5 centers in Brazil N=130
Some concerns
Details

Full description

NCT04446429
Cadegiani FA, Research square , 2021
Full text
Commentary
; Commentary
Mixed Proxalutamide Placebo RCT Male outpatients with confirmed COVID-19 (mild) treated at 2 centers in Brazil. N=262
High
Details

Full description

ChiCTR2000029308
Cao B, N Engl J Med, 2020
Full text
Commentary
Commentary
Mixed Lopinavir-Ritonavir Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in China. N=199
Some concerns
Details

Full description

ChiCTR-OPN-200002958
Cao Y, J Allergy Clin Immun, 2020
Full text
Commentary
Public/non profit Ruxolitinib Vitamin C RCT Patients with COVID-19 (severe) admitted to 3 centers in China. N=43
Some concerns
Details

Full description

NCT04322123
Cavalcanti AB, N Engl J Med, 2020
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with suspected or confirmed COVID-19 (mild-moderate) admitted to 55 centers in Brazil N=667
Some concerns
Details

Full description

Hydroxychloroquine + Azithromycin Standard care
Hydroxychloroquine + Azithromycin Hydroxychloroquine
NCT04390022
Chaccour C, EClinicalMedicine, 2021
Full text
Commentary
Mixed Ivermectin Placebo RCT Outpatients with confirmed COVID-19 (mild) attending the emergency room at a single center in Spain N=24
Some concerns
Details

Full description

ChiCTR2000030254
Chen C, medRxiv, 2020
Full text
Commentary
Public/non profit Favipiravir Umifenovir RCT Patients with confirmed COVID-19 (moderate, Severe/Critical) admitted to 3 center N=240
High
Details

Full description

NCT04384380
Chen CP, Plos one, 2020
Full text
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 11 centers in Taiwan N=33
Some concerns
Details

Full description

NCT04261517
Chen J, Journal of Zhejiang , 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to a single center in China N=30
High
Details

Full description

NCT04252274
Chen J, Open Forum Infect Di, 2020
Full text
Commentary
Public/non profit Darunavir/cobicistat Standard care RCT Patients with COVID-19 (moderate) admitted to a single center in China N=30
High
Details

Full description

ChiCTR2000030054
Chen L, medRxiv, 2020
Full text
Commentary
Public Hydroxychloroquine Chloroquine RCT Patients with confirmed COVID-19 (mild, moderate) admitted to a single center in China N=67
High
Details

Full description

Chloroquine Standard care
Hydroxychloroquine Standard care
ChiCTR2000029559
Chen Z, medRxiv, 2020
Full text
Commentary
and Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to a single center in China. N=62
Some concerns
Details

Full description

ChiCTR2000030007
Cheng L, JAMA Intern Med, 2020
Full text
Commentary
Mixed rhG-CSF Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 3 centers in China N=200
Some concerns
Details

Full description

NCT04434144
Chowdhury ATMM, EJMO, 2021
Full text
Commentary
Commentary
No specific funding Ivermectin+Doxycycline Hydroxychloroquine+Azithromycin RCT Outpatients with confirmed COVID-19 (asymptomatic, mild) treated by a single center in Bangladesh N=125
High
Details

Full description

NCT04338009
Cohen J, Lancet Respir Med, 2021
Full text
Commentary
Commentary
Mixed Continue ARB/ACEI Discontinue ARB/ACEI RCT Patients with suspected and confirmed COVID-19 (unclear severity) admitted to 20 centers in Argentina, Bolivia, Canada, Mexico, Peru, Sweden, USA N=152
Some concerns
Details

Full description

EudraCT202000193437
Corral-Gudino L, medRxiv, 2020
Full text
Commentary
No specific funding Methylprednisolone Standard care RCT Patients with COVID-19 (severe) admitted to 5 centers in Spain N=64
High
Details

Full description

NCT04399980, NCT04463004, NCT04492514
Cremer P, Lancet Rheumatol, 2021
Full text
Commentary
Private Mavrilimumab Placebo RCT Patients with confirmed COVID-19 (moderate/severe) admitted to 7 centers in the USA N=40
Some concerns
Details

Full description

RPCEC00000317
Cruz LR, ACS Pharmacol Trans, 2020
Full text
Commentary
Commentary
Mixed CIGB-325 Standard care RCT Patients with confirmed COVID-19 (asymptomatic-severe) admitted to a single center in Cuba N=20
Some concerns
Details

Full description

NCT04351295
Dabbous H, Arch Virol, 2021
Full text
Commentary
Not reported/unclear Favipiravir Chloroquine RCT Patients with confirmed COVID-19 (unclear severity) admitted to 2 centers in Egypt N=96
Some concerns
Details

Full description

NCT04349241
Dabbous HM, Scientific Reports, 2021
Full text
Commentary
Commentary
Private Favipiravir Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 2 centers in Egypt N=100
Some concerns
Details

Full description

NCT04521400
Darazam I, Research square , 2021
Full text
Commentary
Commentary
No specific funding High dose Interferon-β 1a Low dose Interferon-β 1a RCT Patients with T-PCR and/or chest CT confirmed COVID-19 (moderate-severe) admitted to a single center in Iran. N=168
Some concerns
Details

Full description

NCT04343768
Darazam IA, COVIFERON, 2021
Full text
Commentary
; Commentary
No specific funding Interferon beta-1b Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran. N=60
Some concerns
Details

Full description

Interferon beta-1a Standard care
Interferon beta-1b Interferon beta-1a
IRCT20190727044343N1
Davoodi L, Int J Clin Pract, 2020
Full text
Commentary
Public/non profit Febuxostat Hydroxychloroquine RCT Patients with COVID-19 (mild-moderate) treated at a single center in Iran N=60
Some concerns
Details

Full description

IRCT20100228003449N28
Davoudi-Monfared E, Antimicrob Agents Ch, 2020
Full text
Commentary
Private Interferon beta-1a Standard care RCT Patients with COVID-19 (moderate to critical) admitted to a single center in Iran. N=92
High
Details

Full description

NCT04386694
De Marchi T, medRxiv, 2020
Full text
Commentary
Commentary
Mixed Photobiomodulation therapy Placebo RCT Patients with confirmed COVID-19 (critical) admitted to a single center in Brazil. N=30
Some concerns
Details

Full description

NCT04326790
Deftereos S, JAMA, 2020
Full text
Commentary
Private Colchicine Standard care RCT Patients with COVID-19 (moderate-severe) admitted to 16 centers in Greece. N=110
Some concerns
Details

Full description

RPCEC00000309
Delgado-Enciso I, Research Square, 2020
Full text
Commentary
Commentary
Mixed Neutral electrolyzed saline Standard care RCT Outpatients with confirmed COVID-19 (ambulatory, mild) treated at home in Mexico. N=84
Some concerns
Details

Full description

NCT02517489
Dequin P-F, JAMA, 2020
Full text
Commentary
Public/non profit Hydrocortisone Placebo RCT Patients with COVID-19 (severe-critical) admitted to 9 centers in France N=149
Some concerns
Details

Full description

jRCTs041190120
Doi Y, Antimicrob Agents Ch, 2020
Full text
Commentary
Mixed Favipiravir Favipiravir RCT Patients with confirmed COVID-19 (asymptomatic-mild-moderate) admitted to multiple centers in Japan N=88
Some concerns
Details

Full description

NCT04244591
Du, Unpublished, 2020
Public/non profit Methylprednisolone Standard care RCT Patients with confirmed COVID-19 (severe-critical) admitted to multiple centers in China N=47
Some concerns
Details

Full description

NCT04355936
Duarte M, medRxiv, 2020
Full text
Commentary
Mixed Telmisartan Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to 2 centers in Argentina N=82
Some concerns
Details

Full description

NCT04325893
Dubee V, Clin Microbiol Infec, 2021
Full text
Commentary
Commentary
Public/non profit Hydroxychloroquine Placebo RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 34 centers in France and Monaco. N=250
Some concerns
Details

Full description

IRCT20200404046947N1
Edalatifard M, Eur Respir J, 2020
Full text
Commentary
Public/non profit Intravenous Methylprednisolone pulse Standard care RCT Patients with confirmed COVID-19 (severe) admitted to two centers in Iran N=68
Some concerns
Details

Full description

NCT04668469
Elgazzar A, Research Square , 2020
Full text
Commentary
Commentary
No specific funding Ivermectin Hydroxychloroquine RCT Patients with confirmed COVID-19 (severe) admitted to 2 centers in Egypt N=200
Some concerns
Details

Full description

NCT04668469
Elgazzar A, Research Square, 2020
Full text
Commentary
; Commentary
No specific funding Ivermectin Hydroxychloroquine RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 2 centers in Egypt N=200
Some concerns
Details

Full description

NCT04366908
Entrenas Castillo M, J Steroid Biochem Mo, 2020
Full text
Commentary
Public/non profit Calcifediol Standard care RCT Patients with confimed COVID-19 (moderate-severe) admitted to a single center in Spain N=76
Some concerns
Details

Full description

RPCEC00000307
Esquivel-Moynelo I, medRxiv, 2020
Full text
Commentary
Public/non profit IFN alpha2b+IFN gamma Interferon alpha2b RCT Patients with confirmed COVID-19 (ambulatory, mild) admitted to a single center N=79
High
Details

Full description

IRCT20200406046963N1
Farahani R, Research Square, 2020
Full text
Commentary
Public/non profit Intravenous Methylprednisolone pulse+Prednisolone Standard care RCT Patients with COVID-19 (severe) admitted to a single center in Iran N=29 N/A

Full description

NCT04354259
Feld JJ, Lancet Respir Med, 2021
Full text
Commentary
Commentary
Mixed Peginterferon Lambda-1 Placebo RCT Outpatients with confirmed COVID-19 (mild) tested at 6 centers in Canada N=60
Some concerns
Details

Full description

NCT04348409
Fontanesi Blum V, SSRN, 2021
Full text
Commentary
Private Nitazoxanide Placebo RCT Patients with confirmed COVID-19 (mild/moderate) admitted to 6 centers in Brazil. N=50
Some concerns
Details

Full description

ChiCTR2000030262
Fu W, EClinicalMedicine, 2020
Full text
Commentary
Public/non profit Interferon kappa+TFF2 Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to a single center in China N=80
Some concerns
Details

Full description

NCT04321278
Furtado RHM, Lancet, 2020
Full text
Mixed Hydroxychloroquine + Azithromycin Hydroxychloroquine RCT Patients with suspected or confirmed COVID-19 (moderate-critical) admitted to 57 centers in Brazil N=447
Some concerns
Details

Full description

RBR-8h7q82
Galan L ,Pathog Glob Health, 2021
Full text
Commentary
Public/non profit Ivermectin Hydroxychloroquine RCT Patients with serology or RT-PCR confirmed COVID-19 (moderate-critical) admitted to a single center in Brazil. N=168
*
Details

Full description

Ivermectin Chloroquine
Hydroxychloroquine Chloroquine
RBR-8969zg
Garcia de Alencar JC, CID, 2020
Full text
Commentary
Public/non profit N-acetylcysteine Placebo RCT Patients with COVID-19 (mild-severe) admitted to a single center in Brazil N=140 N/A

Full description

NCT04365127
Ghandehari S, SSRN, 2020
Full text
Commentary
; Commentary
Private Progesterone Standard care RCT Patients with confirmed COVID-19 (mild-severe) admitted to a single center in the USA. N=42
Some concerns
Details

Full description

NCT04342182
Gharbharan A, medRxiv, 2020
Full text
Mixed Convalescent plasma Standard care RCT Patients with COVID-19 (moderate-critical) admitted to 14 centers in the Netherlands N=86
Some concerns
Details

Full description

IRCT20200501047259N1
Gharebaghi N, BMC Infect Dis., 2020
Full text
Commentary
Public/non profit Intravenous Immunoglobulin Placebo RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran N=59 N/A

Full description

NCT04292899
Goldman JD, N Engl J Med, 2020
Full text
Results in clinicaltrials.gov
Full text
Commentary
and Commentary
Private Remdesivir 5 days Remdesivir 10 days RCT Patients with confirmed COVID-19 (moderate to critical) admitted to 55 centers across 5 countries. N=402
Some concerns
Details

Full description

Forest plots
NCT02735707, NCT04505774, NCT04359277, NCT04372589
Goligher E, medRxiv, 2021
Full text
Commentary
Commentary
Commentary
Mixed Therapeutic heparin Prophylactic anticoagulant RCT Patients with confirmed COVID-19 (severe-critical) admitted to 393 centers in Australia, Brazil, Canada, Ireland, Mexico, Netherlands, New Zealand, Saudi Arabia, UK, USA N=1205
Some concerns
Details

Full description

ISRCTN59048638
Gonzalez-Ochoa AJ , Thromb Haemost, 2021
Full text
Commentary
Commentary
Private Sulodexide Placebo RCT Outpatients with confirmed COVID-19 (mild) of a single center in Mexico N=312
Some concerns
Details

Full description

NCT02735707
Gordon AC, REMAP-CAP, 2021
Full text
Commentary
Commentary
Mixed Tocilizumab Standard care RCT Patients with confirmed or suspected COVID-19 (severe-critical) admitted to 113 centers in Australia, Ireland, the Netherlands, New Zealand, Saudi Arabia, UK. N=826
Some concerns
Details

Full description

Sarilumab Standard care
NCT04427501
Gottlieb R, BLAZE-1, 2021
Full text
Commentary
Commentary
Private LY-CoV555 700 mg Placebo RCT Outpatients with COVID-19 (mild ambulatory) treated at 49 centers in USA N=592
Some concerns
Details

Full description

LY-CoV555 2800 mg Placebo
LY-CoV555 7000 mg Placebo
LY-CoV555+LY-CoV016 Placebo
N/A
Guvenmez O, J Popul Ther Clin Pharmacol, 2020
Full text
Commentary
No specific funding Lincomycin Azithromycin RCT Patients with confirmed COVID-19 (moderate) admitted to a single center in Turkey N=24
Some concerns
Details

Full description

new
NCT04414124
Haran J, medRxiv, 2021
Full text
Commentary
thread Commentary
Private KB109 Standard care RCT Outpatients with confirmed COVID-19 (mild) treated by 16 centers in the USA. N=350
Some concerns
Details

Full description

NCT04591600
Hashim A, medRxiv, 2020
Full text
Commentary
Commentary
Public/non profit Ivermectin+Doxycycline Standard care RCT Outpatients and inpatients with COVID-19 (unclear severity) treated at 2 centers in Iraq N=140
High
Details

Full description

NCT04331808
Hermine O, JAMA Intern Med, 2020
Full text
Commentary
Public/non profit Tocilizumab Standard care RCT Patients with COVID-19 (moderate-severe) admitted to nine centers in France N=131
Some concerns
Details

Full description

NCT04315896
Hernandez-Cardenas C, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Patients with RT-PCR confirmed COVID-19 (severe-critical) admitted to 3 centers in Mexico N=214
Some concerns
Details

Full description

NCT04682873
Holubovska O, medRxiv, 2021
Full text
Commentary
; Commentary
Mixed Enisamium Placebo RCT Patients with confirmed COVID-10 (mild/moderate) admitted to 15 centers in Ukraine N=373
High
Details

Full description

NCT04381936
Horby P, Lancet, 2020
Full text
Commentary
Mixed Lopinavir-Ritonavir Standard care RCT Patients with suspected or confirmed COVID-19 (mild-critical) admitted to 163 centers in the UK N=5040
Some concerns
Details

Full description

NCT04381936 ; ISRCTN (50189673)
Horby P, Lancet, 2021
Full text
Commentary
Commentary
Mixed Azithromycin Standard care RCT Patients with suspected or confirmed COVID-19 (mild to critical) admitted to 176 centers in the UK N=7763
Some concerns
Details

Full description

NCT04381936, ISRCTN50189673
Horby P, medRxiv, 2021
Full text
Commentary
Public/non profit Tocilizumab Standard care RCT Patients with suspected or confirmed COVID-19 (moderate-critical) admitted to 131 centers in the UK N=4116
Some concerns
Details

Full description

NCT04381936; EudraCT 2020-001113-21; ISRCTN5018967
Horby P, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with suspected or confirmed COVID-19 (mild-moderate-severe-critical) admitted to 177 centers in the UK. N=11558
Some concerns
Details

Full description

NCT04381936
RECOVERY Trial
Horby P, N Engl J Med, 2020
Full text
Commentary
Mixed Dexamethasone Standard care RCT Patients with suspected and confirmed COVID-19 (moderate-critical) admitted to 176 centers in the UK N=6425
Some concerns
Details

Full description

Forest plot
(sub group)
NCT04381936
Horby P, N Engl J Med, 2020
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild-critical) admitted to 176 centers in the UK N=4716
Some concerns
Details

Full description

ChiCTR2000029387
Huang YQ, Front Pharmacol, 2020
Full text
Commentary
Public/non profit Ribavirin+Lopinavir+Ritonavir+Interferon alpha Ribavarin+Interferon alpha RCT Patients with confirmed COVID-19 (moderate) admitted to a single center in China N=101
Some concerns
Details

Full description

Lopinavir+Ritonavir+Interferon alpha Ribavarin+Interferon alpha
Ribavirin+Lopinavir+Ritonavir+Interferon alpha Lopinavir+Ritonavir+Interferon alpha
NCT04276688
Hung IF-N, Lancet, 2020
Full text
Commentary
Commentary
Public/non profit LPV/r+RBV+IFN beta1 Lopinavir-Ritonavir RCT Patients with confirmed COVID-19 (unclear severity) admitted to six centers in Hong-Kong N=127
Some concerns
Details

Full description

NCT04434248
Ivashchenko AA, Clin Infect Dis, 2020
Full text
Commentary
Mixed Favipiravir 1800/800mg Favipiravir 1600/600mg RCT Patients with confirmed COVID-19 (moderate) admitted to 6 centers in Russia N=60
Some concerns
Details

Full description

Forest plots
Favipiravir 1600/600mg Standard care
Favipiravir 1800/800mg Standard care
NCT04331899
Jagannathan P, Nature, 2021
Full text
Commentary
Commentary
Mixed Peginterferon Lambda-1a Placebo RCT Outpatients with confirmed COVID-19 (asymptomatic/symptomatic, mild) treated at a single center in the USA N=120
Some concerns
Details

Full description

IRCT20151227025726N17
Jamaati H, Eur J Pharmacol, 2021
Full text
Commentary
Public/non profit Dexamethasone Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran N=50
High
Details

Full description

IRCT20200411047025N1
JamaliMoghadamSiahkali S, Eur J Med Res, 2021
Full text
Commentary
Public/non profit Vitamin C Standard care RCT Patients with suspected or confirmed COVID-19 (severe) admitted to a single center in Iran N=60 N/A

Full description

NCT04401579
Kalil A, N Engl J Med, 2020
Full text
Commentary
Public/non profit Baricitinib+Remdesivir Placebo+Remdesivir RCT Patients with confirmed COVID-19 (mild-critical) admitted to 67 centers in Denmark, Japan, Mexico, Singapore, South Korea, Spain, UK, USA. N=1033
Low
Details

Full description

N/A
Khamis F, Int J Infect Dis, 2020
Full text
Commentary
No specific funding Favipiravir+Interferon beta-1b Hydroxychloroquine RCT Patients with confirmed COVID-19 (moderate-severe) treated at a single center in Oman N=89
Some concerns
Details

Full description

NCT04739410
Khan Chachar AZ, Int J Sci, 2020
Full text
Commentary
No specific funding Ivermectin Standard care RCT Outpatients with confirmed COVID-19 (symptomatic-mild) treated at a single center in Pakistan N=50
High
Details

Full description

CTRI/2020/08/027225
Kirti R, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Ivermectin Placebo RCT Patients with COVID-19 (mild-severe) admitted to a single center in India N=115
High
Details

Full description

NCT04381884
Krolewiecki A, SSRN, 2020
Full text
Commentary
Commentary
Mixed Ivermectin Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 4 centers in Argentina N=45
Some concerns
Details

Full description

CTRI/2020/05/024959
Kumar S, medRxiv, 2020
Full text
Commentary
Commentary
Private Itolizumab Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 4 centers in India N=32
Some concerns
Details

Full description

N/A
Kumari P, Cureus, 2020
Full text
Commentary
Commentary
Not reported/unclear Vitamin C Standard care RCT Patients with COVID-19 (severe) admitted to a single center in Pakistan N=150 N/A

Full description

NCT04355728
Lanzoni G, Stem Cells Transl Me, 2020
Full text
Full text
Commentary
Commentary
Mixed Umbilical cord mesenchymal stem cell infusion Placebo RCT Patients with confirmed COVID-19 (severe-critical) admitted to a single center in USA N=24
Some concerns
Details

Full description

RBR-949z6v
Lemos ACB, Thromb Res, 2020
Full text
Commentary
No specific funding Therapeutic enoxaparin Prophylactic anticoagulant RCT Patients with confirmed COVID-19 (critical) admitted to a single center in Brazil N=20
Some concerns
Details

Full description

NCT04342663
Lenze E, JAMA, 2020
Full text
Commentary
Commentary
Mixed Fluvoxamine Placebo RCT Outpatients with confirmed COVID-19 (ambulatory, mild) treated at home in USA N=181
Low
Details

Full description

NCT04327388; EudraCT2020-001162-12; U1111-1249-602
Lescure FX, 2021
Full text
Commentary
Commentary
Private Sarilumab 400mg Placebo RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 45 centers in Argentina, Brazil, Canada, Chile, France, Germany, Israel, Italy, Japan, Russia, and Spain. N=420
Some concerns
Details

Full description

Sarilumab 200mg Placebo
Sarilumab 400mg Sarilumab 200mg
ChiCTR2000029638
Li C, Ann. Med, 2021
Full text
Commentary
Commentary
Mixed Recombinant super-compound interferon Interferon alpha RCT Patients with COVID-19 (moderate-severe) admitted to 5 centers in China N=96
Some concerns
Details

Full description

ChiCTR2000029757
Li L, JAMA, 2020
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with COVID-19 (severe to critical) admitted to 7 centers in China N=103
High
Details

Full description

NCT04273763
Li T, Clin Transl Sci , 2020
Full text
Commentary
Public/non profit Bromhexine Standard care RCT Patients with confirmed or suspected COVID-19 (mild-moderate) admitted to a single center in China N=18
Some concerns
Details

Full description

NCT04479163
Libster R, N Engl J Med, 2021
Full text
Commentary
Public/non profit Convalescent plasma Placebo RCT Patients with confirmed COVID-19 (mild) admitted to multiple centers in Argentina N=160
Some concerns
Details

Full description

EudraCT 2020-001243-1
Liesenborghs L, SSRN, 2020
Full text
Commentary
Commentary
Public/non profit Itraconazole Standard care RCT Patients with confirmed or suspected COVID-19 (unclear severity) admitted to a single center in Belgium N=65
Some concerns
Details

Full description

NCT04494984
Lopardo G, SSRN, 2021
Full text
Commentary
Mixed INM005 Placebo RCT Patients with confirmed (RT-PCR) COVID-19 (mild-severe) pneumonia admitted to 19 centers in Argentina N=245
Some concerns
Details

Full description

RBR-8jyhxh
Lopes MIF, RMD Open, 2021
Full text
Commentary
Public/non profit Colchicine Placebo RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Brazil N=75
Some concerns
Details

Full description

NCT04364893
Lopes RD, JAMA, 2021
Full text
Commentary
Not reported/unclear Discontinue ARB/ACEI Continue ARB/ACEI RCT Patients with suspected COVID-19 (unclear severity) at 29 centers in Brazil N=740
Low
Details

Full description

NCT04405843
Lopez-Medina E, JAMA, 2021
Full text
Commentary
Commentary
Mixed Ivermectin Placebo RCT Outpatients with confirmed COVID-19 (mild) treated by a single center in Colombia N=476
Low
Details

Full description

ChiCTR2000029544
Lou Y, 2020
Full text
Commentary
Public/non profit Favipiravir Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to a single center in China N=30
Some concerns
Details

Full description

Baloxavir marboxil Standard care
Favipiravir Baloxavir marboxil
NCT04501978
Lundgren J, N Engl J Med, 2020
Full text
Commentary
Mixed LY-CoV555 Placebo RCT Patients with confirmed COVID-19 (mild-severe) admitted to 31 centers in Denmark, Singapore and USA N=326
Low
Details

Full description

NCT04316377
Lyngbakken MN, Nature, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Standard care RCT Patients with confirmed COVID-19 (mild-severe) admitted to a single center in Norway N=53
High
Details

Full description

NCT04523831
Mahmud R, Unpublished, 2020
Full text
Mixed Ivermectin+Doxycycline Placebo RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in Bangladesh N=400
High
Details

Full description

N/A
Maldonado V, INT IMMUNOPHARMACOL, 2020
Full text
Commentary
No specific funding Pentoxifylline Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Mexico N=54 N/A

Full description

RBR-5s2mqg
Mansour E, medRxiv, 2020
Full text
Commentary
Public/non profit Icatibant Standard care RCT Patients with COVID-19 (severe) admitted to a single center in Brazil N=30
Some concerns
Details

Full description

C1 Esterase/Kallikrein Inhibitor Standard care
Icatibant C1 Esterase/Kallikrein Inhibitor
NCT04341584
Mariette X CORIMUNO-ANA, Lancet Respir Med, 2021
Full text
Commentary
Public/non profit Anakinra Standard care RCT Patients with COVID-19 (moderate) admitted to 16 centers in France. N=116
Some concerns
Details

Full description

NCT04468646
Mehboob R, medRxiv, 2020
Full text
Commentary
No specific funding Aprepitant+Dexamethasone Dexamethasone RCT Patients with confirmed COVID-19 (mild-critical) admitted to a single center in Pakistan N=41
Some concerns
Details

Full description

NCT04345614
Miller J, Crit Care, 2020
Full text
Commentary
Private Auxora Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to 3 centers in USA N=26
Some concerns
Details

Full description

NCT04304053
Mitja O, Clin Infect Dis, 2020
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Outpatients with COVID-19 (mild) in an ambulatory setting in Spain N=353
Some concerns
Details

Full description

IRCT20200624047908N1
Mobarak S, SSRN, 2021
Full text
Commentary
Commentary
Public/non profit Sofosbuvir-Daclatasvir Placebo RCT Patients with suspected or confirmed COVID-19 (moderate-severe) admitted to 19 centers in Iran N=1083
Some concerns
Details

Full description

CTRI/2020/06/026001
Mohan A, 2021
Full text
Commentary
Mixed Ivermectin 12 mg Placebo RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in India N=152
Some concerns
Details

Full description

Ivermectin 24 mg Placebo
Ivermectin 12 mg Ivermectin 24 mg
NCT04385095 ; EudraCT 2020-001023-14
Monk PD, Lancet Respir Med, 2020
Full text
Commentary
Commentary
Private Nebulised interferon beta-1a Placebo RCT Patients with confirmed COVID-19 (mild-severe) admitted to nine centers in the UK N=101
Some concerns
Details

Full description

NCT04449718
Murai IH, Jama, 2021
Full text
Commentary
Commentary
Public/non profit Cholecalciferol Placebo RCT Patients with COVID-19 (mild-severe) admitted to 2 centres in Brazil N=240
Some concerns
Details

Full description

IRCT20200408046987N1
Niaee MS, 2020
Full text
Commentary
Commentary
Mixed Ivermectin Once-off Standard care RCT Patients with CT or PCR confirmed COVID-19 (unclear severity) admitted to 5 centers in Iran. N=180
Some concerns
Details

Full description

Ivermectin Once-off Placebo
Ivermectin 3-day LD Standard care
Ivermectin 3-day LD Placebo
Ivermectin 1-day BDS Standard care
Ivermectin 1-day BDS Placebo
Ivermectin 3-day HD Standard care
Ivermectin 3-day HD Placebo
IRCT20180725040596N2
Nojomi M, BMC Infect Dis., 2020
Full text
Commentary
Public/non profit Hydroxychloroquine+Umifenovir Hydroxychloroquine+Lopinavir+Ritonavir RCT Patients with COVID-19 (moderate-severe) admitted to a single center in Iran N=100
Some concerns
Details

Full description

IRCT20180802040678N4
Nouri-Vaskeh M, Int J Clin Pract, 2021
Full text
Commentary
Public/non profit Losartan Amlodipine RCT Patients with confirmed COVID-19 (mild-moderate-severe-critical) admitted to a single center in Iran N=82
Some concerns
Details

Full description

IRCT20100228003449N29
Nourian A, Acta Biomed, 2020
Full text
Commentary
Mixed Sofosbuvir-ledipasvir Standard care RCT Patients with suspected or confirmed COVID-19 (mild-severe) admitted to a single center in Iran N=90
Some concerns
Details

Full description

NCT04359810
O Donnell M, medRxiv, 2021
Full text
Commentary
Commentary
Not reported/unclear Convalescent plasma Control plasma RCT Patients with confirmed COVID-19 (mild-critical) admitted to 5 centers in Brazil and USA N=223
Low
Details

Full description

NCT04646109
Okumus N, Research Square, 2021
Full text
Commentary
Commentary
Public/non profit Ivermectin Standard care RCT Patients with confirmed COVID-19 (severe) admitted to four centers in Turkey N=66
High
Details

Full description

NCT04349592
Omrani A (Q-PROTECT), EClinicalMedicine, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine+Azithromycin Placebo RCT Patients with confirmed COVID-19 (mild) treated at two centers in Qatar N=456
Some concerns
Details

Full description

Hydroxychloroquine Placebo
Hydroxychloroquine+Azithromycin Hydroxychloroquine
CTRI/2020/05/025013
Padmanabhan U, medRixv, 2020
Full text
Commentary
Commentary
Mixed Bacille Calmette-Guérin Placebo RCT “Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in India” N=60
Some concerns
Details

Full description

ISRCTN83971151; NCT04315948
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Remdesivir Standard care RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries N=5475
Low
Details

Full description

ISRCTN83971151; NCT04315948
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Interferon beta-1a Standard care RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries. N=4127
Low
Details

Full description

ISRCTN83971151; NCT04315948
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Lopinavir-Ritonavir Standard care RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries. N=2791
Low
Details

Full description

ISRCTN83971151; NCT04315948
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries N=1863
Low
Details

Full description

new
CTRI/2020/06/026087
Pandit A, Int J Infect Dis, 2021
Full text
Commentary
Private Pegylated Interferon alpha-2b Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 6 centers in India N=40
Some concerns
Details

Full description

ACTRN12620000454976
Patel O, J Med Virol, 2021
Full text
Commentary
Public/non profit Zinc Placebo RCT Patients with confirmed COVID-19 (mild-critical) admitted to a single center in Australia N=33
Low
Details

Full description

NCT04348305
Perner A, Unpublished, 2020
Mixed Hydrocortisone Placebo RCT Patients with confirmed COVID-19 (severe-critical) admitted to 19 centers in Denmark. N=29
Low
Details

Full description

N/A
Podder C, IMC J Med Sci, 2020
Full text
No specific funding Ivermectin Standard care RCT Outpatients with confirmed COVID-19 (mild-moderate) treated at a single center in Bangladesh N=62
High
Details

Full description

NCT04431466
Pott-Junior H, 2021
Full text
Commentary
No specific funding Ivermectin 100 mcg/kg Standard care RCT Patients with RT-PCR confirmed COVID-19 (symptomatic mild) admitted to a single center in Brazil. N=32
Some concerns
Details

Full description

Ivermectin 100 mcg/kg Ivermectin 200 mcg/kg
Ivermectin 100 mcg/kg Ivermectin 400 mcg/kg
Ivermectin 200 mcg/kg Standard care
Ivermectin 200 mcg/kg Ivermectin 400 mcg/kg
Ivermectin 400 mcg/kg Standard care
new
IRCT20200310046736N1
Pouladzadeh M, Intern Emerg Med, 2021
Full text
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe-critical) admitted to a single center in Iran N=62
Some concerns
Details

Full description

NCT04343729
Prado Jeronimo CM, Clin Infect Dis, 2020
Full text
Commentary
Public/non profit Methylprednisolone Placebo RCT Patients with COVID-19 (moderate-critical) admitted to a single center in Brazil N=416
High
Details

Full description

INA-TX6YYSS
Purwati, 2021
Full text
Commentary
Public/non profit Lopinavir-Ritonavir(Low dose)+Azithromycin Azithromycin RCT NR N=759
*
Details

Full description

Lopinavir-Ritonavir(Low dose)+Doxycycline Azithromycin
Hydroxychloroquine+Azithromycin Azithromycin
Lopinavir-Ritonavir+Azithromycin Azithromycin
Lopinavir-Ritonavir+Doxycycline Azithromycin
RCT20100228003449N27
Rahmani H, Int Immunopharmacol, 2020
Full text
Commentary
No specific funding Interferon beta-1b Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Iran N=80
Some concerns
Details

Full description

NCT04416399
Ramakrishnan S, Lancet Respir Med, 2021
Full text
Commentary
Commentary
Mixed Budesonide Standard care RCT Outpatients with suspected or confirmed COVID-19 (mild) treated by a single center in the UK N=146 N/A

Full description

CTRI/2020/06/026222
Raman RS, J Infect Dis, 2021
Full text
Commentary
Private Intravenous Immunoglobulin Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to four centers in India N=100
Some concerns
Details

Full description

IRCT20200204046369N1
Ranjbar K, Research square, 2021
Full text
Commentary
Commentary
No specific funding Methylprednisolone Dexamethasone RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran N=93
Some concerns
Details

Full description

*
Rashad A, 2021
Full text
Commentary
Commentary
Not reported/unclear Azithromycin Standard care RCT Patients with confirmed COVID-19 (mild outpatients) treated at a single center in Egypt N=305
*
Details

Full description

Azithromycin Clarithromycin
Clarithromycin Standard care
N/A
Rasheed A, Le Infezioni in Medicina, 2020
Full text
Public/non profit Convalescent plasma Standard care RCT Patients with COVID-19 (severe) admitted to 3 centers in Iraq. N=49 N/A

Full description

NCT04459247
Rastogi A, Postgrad Med J, 2020
Full text
Commentary
Commentary
No specific funding Cholecalciferol Placebo RCT Patients with confirmed COVID-19 (symptomatic or asymptomatic mild) admitted to a single center in India N=40 N/A

Full description

CTRI/2020/05/025209
Ray Y, medRxiv, 2020
Full text
Commentary
Commentary
Public/non profit Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in India N=80
High
Details

Full description

ChiCTR2000029853
Ren Z, Adv Sci, 2020
Full text
Commentary
Mixed Azvudine Standard care RCT Patients with COVID-19 (mild-moderate) admitted to a single center in China N=20
Some concerns
Details

Full description

NCT04552483
Rocco PRM, Eur Respir J, 2020
Full text
Commentary
Mixed Nitazoxanide Placebo RCT Outpatients with confirmed COVID-19 (mild) treated at 7 centers in Brazil N=475
Some concerns
Details

Full description

IRCT20190810044500N7
Roostaei A, BMC Infect Dis, 2021
Full text
Commentary
Commentary
Public/non profit Levamisole Placebo RCT Outpatients with COVID-19 (mild) treated at a single center in Iran N=52
Some concerns
Details

Full description

IRCT20200403046926N1
Roozbeh F, J Antimicrob Chemother, 2020
Full text
Commentary
Public/non profit Sofosbuvir-Daclatasvir Standard care RCT Outpatients with COVID-19 (mild) treated at a single center in Iran N=60 N/A

Full description

NCT04320615
Rosas I, N Engl J Med, 2021
Full text
Commentary
Mixed Tocilizumab Placebo RCT Patients with confirmed COVID-19 (mild-critical) admitted to multiple centers across 9 countries N=452
Low
Details

Full description

NCT04501783
Ruzhentsova T, SSRN, 2020
Full text
Commentary
; Commentary
Private Favipiravir Standard care RCT Patients (and outpatients) with confirmed COVID-19 (mild-moderate) treated at 10 centers in Russia N=168
Some concerns
Details

Full description

IRCT20200128046294N2
Sadeghi A, J Antimicrob Chemoth, 2020
Full text
Commentary
Mixed Sofosbuvir-Daclatasvir Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 4 centers in Iran N=70
Some concerns
Details

Full description

NCT04486508
Sadeghipour P, JAMA, 2021
Full text
Commentary
Commentary
Commentary
Mixed Intermediate-Dose prophylactic anticoagulation Standard-Dose prophylactic anticoagulation RCT Patients with confirmed COVID-19 (critical) admitted to 10 centers in Iran N=598
Some concerns
Details

Full description

NCT04411667
Sakoulas G, Crit Care Expl , 2020
Full text
Commentary
Private Intravenous Immunoglobulin Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 2 centers in USA. N=34
Some concerns
Details

Full description

NCT04372186
Salama C, N Engl J Med, 2020
Full text
Full text
Commentary
Commentary
Private Tocilizumab Placebo RCT Patients with confirmed COVID-19 (mild-severe) admitted to 65 centers in Brazil, Kenya, Mexico, Peru, South Africa, and USA N=388
Some concerns
Details

Full description

IRCT20200418047126N1
Salehzadeh F, Research Square, 2020
Full text
Commentary
Public/non profit Colchicine Placebo RCT Patients with confirmed COVID-19 (unclear severity) admitted to a single center in Iran N=100
Some concerns
Details

Full description

N/A
Sali S, Novelty in Biomedicine, 2021
Full text
Public/non profit Hydroxychloroquine+Sofosbuvir Hydroxychloroquine+Lopinavir-Ritonavir RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Iran N=54
Some concerns
Details

Full description

NCT04530370
Salman OH, Egypt J Anaesth, 2020
Full text
Commentary
Not reported/unclear Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Egypt N=30
Some concerns
Details

Full description

NCT04346355
Salvarani C, JAMA , 2020
Full text
Commentary
Mixed Tocilizumab Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 24 centers in Italy N=126
Some concerns
Details

Full description

IRCT20200511047399N1
Sedighiyan M, Authorea, 2021
Full text
Commentary
Public/non profit Hydroxychloroquine+Omega-3 Hydroxychloroquine RCT Patients with COVID-19 (unclear severity) admitted to a single center in Iran N=39 N/A

Full description

IRCT20200415047092N1
Sekhavati E, Int J Antimicrob Age, 2020
Full text
Commentary
Public/non profit Azithromycin Standard care RCT Patients with COVID-19 confirmed (moderate-severe) admitted to a single center in Iran N=111
Some concerns
Details

Full description

NCT04332991
Self W, JAMA, 2020
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Placebo RCT Patients with COVID-19 confirmed (mild-critical) admitted to 34 centers in the USA N=479
Some concerns
Details

Full description

NCT04392713
Shah Bukhari K H, medRxiv, 2021
Full text
Commentary
Commentary
Not reported/unclear Ivermectin Standard care RCT Patients with confirmed COVID-19 (mild) admitted to a single center in Pakistan N=100
High
Details

Full description

CTRI/2020/07/026354
Shah M, Int Immunopharmacol, 2021
Full text
Commentary
Private Oxygen-Ozone Standard care RCT Patients with confirmed COVID-19 (mild) admitted to a single center in India N=60
High
Details

Full description

NCT04288102
Shi L, Signal Transduction , 2021
Full text
Commentary
Public/non profit Human umbilical cord mesenchymal stem cell infusion Placebo RCT Patients with confirmed COVID-19 (severe) admitted to two centers in China N=101
Some concerns
Details

Full description

N/A
Shogenova LV, Pulmonologiya, 2020
Full text
Commentary
Not reported/unclear Thermal helium-oxygen mixture Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in Russia N=60
Some concerns
Details

Full description

ChiCTR2000031494
Shu L, Stem Cell Res Ther, 2020
Full text
Commentary
Public/non profit Human umbilical cord mesenchymal stem cell infusion Standard care RCT Patients with COVID-19 (severe) admitted to a single center China N=41
Some concerns
Details

Full description

NCT04512027; CTRI/2020/09/027833
Sigamani A, J Vaccines Vaccin, 2020
Full text
Commentary
Private Prolectin-M Standard care RCT Patients with confirmed COVID-19 (mild) admitted to a single center in India N=10
Some concerns
Details

Full description

NCT04463264
Silva M, medRxiv, 2021
Full text
Commentary
Commentary
Private Nitazoxanide Placebo RCT Outpatients and inpatients with confirmed COVID-19 (asymptomatic or symptomatic-mild) treated by or admitted to two centers in Argentina N=46
High
Details

Full description

NCT04383535
Simonovich VA, N Engl J Med, 2020
Full text
Commentary
Mixed Convalescent plasma Placebo RCT Patients with confirmed COVID-19 (severe) admitted to 12 centers in Argentina N=334
Some concerns
Details

Full description

new
NCT04402866; EudraCT 2020-001807-18
Singh D, 2021
Full text
Commentary
Commentary
Private TD-0903 1 mg Placebo RCT Patients with confirmed COVID-19 (moderate) admitted to centers in Moldova, UK and Ukraine. N=25
Some concerns
Details

Full description

TD-0903 1 mg TD-0903 3 mg
TD-0903 1 mg TD-0903 10 mg
TD-0903 3 mg Placebo
TD-0903 3 mg TD-0903 10 mg
TD-0903 10 mg Placebo
NCT04308668
Skipper CP, Ann Intern Med, 2020
Full text
Commentary
Private Hydroxychloroquine Placebo RCT Outpatients with suspected or confirmed COVID-19 (symptomatic, mild) with high-risk exposure within 4 days of symptom onset N=491
Some concerns
Details

Full description

CTRI/2020/05/025369
Soin AS, Lancet Respir Med, 2021
Full text
Commentary
Mixed Tocilizumab Standard care RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 12 centers in India N=180
Some concerns
Details

Full description

new
IRCT20200318046812N1
Solaymani-Dodaran M, Int Immunopharmacol, 2021
Full text
Commentary
Public/non profit Favipiravir Lopinavir-Ritonavir RCT Patients with suspected or confirmed COVID-19 (severe) admitted to 20 centers in Iran N=424
Some concerns
Details

Full description

NCT04292730
Spinner CD, JAMA, 2020
Full text
Commentary
Private Remdesivir 5 days Standard care RCT Patients with COVID-19 (mild-severe) admitted to 105 centers in the USA, Europe and Asia N=596
Some concerns
Details

Full description

Remdesivir 10 days Standard care
Remdesivir 5 days Remdesivir 10 days
NCT04356937
Stone JH, N Engl J Med, 2020
Full text
Commentary
Private Tocilizumab Placebo RCT Patients with COVID-19 (mild-severe) admitted to seven centers in USA N=243
Low
Details

Full description

IRCT20151227025726N20
Tabarsi P, Int Immunopharmacol, 2020
Full text
Commentary
Public/non profit Intravenous Immunoglobulin Standard care RCT Patients with COVID-19 (severe) admitted to a single center in Iran N=84
Some concerns
Details

Full description

ChiCTR2000029868
Tang W, BMJ, 2020
Full text
Commentary
Commentary
Mixed Hydroxychloroquine Standard care RCT Patients with COVID-19 (mild, moderate and severe) admitted to 16 centers in China N=150
Some concerns
Details

Full description

NCT04273321
Tang X, Respiration, 2021
Full text
Commentary
Public/non profit Methylprednisolone Placebo RCT Patients with confirmed COVID-19 (moderate/severe) admitted to 7 centers in China. N=86
Some concerns
Details

Full description

NCT04322682
Tardif JC, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Colchicine Placebo RCT Outpatients with suspected or confirmed COVID-19 (mild) at multiple centers in Brazil, Canada, Greece, South Africa, Spain, USA N=4488
Some concerns
Details

Full description

CTRI/2020/04/024729
Thakar A, Indian J Med Res, 2021
Full text
Commentary
Commentary
Public/non profit Chloroquine Standard care RCT Patients with confirmed COVID-19 (asymptomatic-mild) admitted to a single center in India N=60
Some concerns
Details

Full description

NCT04342728
Thomas S, COVID A to Z, 2021
Full text
Commentary
Commentary
Not reported/unclear Vitamin C Standard care RCT Outpatients with confirmed COVID-19 (asymptomatic-mild) treated by multiple centers in the US. N=214
Some concerns
Details

Full description

Vitamin C Zinc
Vitamin C Vitamin C+Zinc
Zinc Vitamin C+Zinc
Zinc Standard care
Vitamin C+Zinc Standard care
IRCT20151227025726N24
Tolouian R, J Investig Med, 2021
Full text
Commentary
Commentary
No specific funding Bromhexine hydrochloride Standard care RCT Patients with confirmed COVID-19 pneumonia (symptomatic, unclear severity) admitted to a single center in Iran N=111
High
Details

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NCT04327401
Tomazini BM, JAMA, 2020
Full text
Commentary
Mixed Dexamethasone Standard care RCT Patients with suspected or confirmed COVID-19 (critical) admitted to 41 centers in Brazil N=299
Some concerns
Details

Full description

NCT04452435
Tornling G, medRxiv, 2021
Full text
Commentary
Commentary
Mixed Compound 21 Placebo RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 8 centers in India N=106
Some concerns
Details

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CTRI/2020/05/025114
Udwadia Z, Int J Infect Dis, 2020
Full text
Commentary
Private Favipiravir Standard care RCT Patients with confirmed COVID-19 (mild/moderate) admitted to 7 centers in India N=150
Some concerns
Details

Full description

NCT04369742
Ulrich RJ, Open Forum Infect Di, 2020
Full text
Commentary
Public/non profit Hydroxychloroquine Placebo RCT Patients with confirmed COVID-19 (mild-severe) admitted to 5 centers in USA N=128
Some concerns
Details

Full description

NCT04403685
Veiga VC, BMJ, 2021
Full text
Commentary
Commentary
Mixed Tocilizumab Standard care RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 9 centers in Brazil N=129
Some concerns
Details

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NCT04325061
Villar J, Unpublished, 2020
Public/non profit Dexamethasone Standard care RCT Patients with confirmed COVID-19 (critical) admitted 14 centers in Spain N=19
Low
Details

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NCT04333420
Vlaar APJ, Lancet Rheumatol, 2020
Full text
Commentary
Private IFX-1 Standard care RCT Patients with confirmed COVID-19 (moderate-critical) admitted to three centers N=30
Some concerns
Details

Full description

ChiCTR2000029765
Wang D, Front Med, 2021
Full text
Full text
Commentary
Public/non profit Tocilizumab Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 6 centers in China N=65
Some concerns
Details

Full description

ChiCTR2000030058
Wang M, Clin Infect Dis, 2020
Full text
Commentary
Public/non profit Leflunomide + Interferon alpha2a Interferon alpha2a RCT Patients with confirmed COVID-19 (mild) admitted to a single center China N=50
Some concerns
Details

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NCT04257656
Wang Y, Lancet, 2020
Full text
Commentary
Mixed Remdesivir Placebo RCT Patients with confirmed COVID-19 (severe) admitted to 10 centers in China N=237
Some concerns
Details

Full description

NCT04425629
Weinreich DM, N Engl J Med, 2020
Full text
Commentary
Mixed REGN-COV2 Placebo RCT Outpatients with COVID-19 (symtomatic-mild) treated at 27 centers in USA N=275
Low
Details

Full description

ChiCTR2000030001
Wu X, Engineering, 2020
Full text
Commentary
Public/non profit Triazavirin Placebo RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 10 centers in China N=52
Some concerns
Details

Full description

DRKS00022203
Yakoot M, SSRN, 2020
Full text
Commentary
Commentary
Private Sofosbuvir-Daclatasvir Standard care RCT Patients with confirmed COVID-19 (mild-severe) admitted to a single center in Egypt N=89
Some concerns
Details

Full description

N/A
Yethindra V, Int. J. Pharm. Sci. Res., 2020
Full text
Commentary
No specific funding Umifenovir Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in Kyrgyzstan N=30
Some concerns
Details

Full description

ChiCTR2000029431
Yuan, medRxiv, 2020
Full text
Commentary
Public/non profit Tc-MDP Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to 2 centers in China N=21 N/A

Full description

NCT04252885
Yueping L, CellPress, 2020
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Commentary
Public/non profit Lopinavir + Ritonavir Standard care RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in China. N=86
Some concerns
Details

Full description

Umifenovir Lopinavir + Ritonavir
Umifenovir Standard care
NCT04264533
Zhang J, Ann. Intensive Care, 2021
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Commentary
Public/non profit Vitamin C Placebo RCT Patients with confirmed COVID-19 (severe-critical) admitted to 3 centers in China N=56
Some concerns
Details

Full description

ChiCTR2000030894, NCT04310228
Zhao H, Biomed Pharmacother, 2020
Full text
Commentary
Public/non profit Favipiravir Favipiravir+Tocilizumab RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 4 centers in China N=26
Some concerns
Details

Full description

Tocilizumab Favipiravir+Tocilizumab
Favipiravir Tocilizumab
ChiCTR2000029496
Zheng F, Int J Infect Dis, 2020
Full text
Commentary
Public/non profit Novaferon Lopinavir + Ritonavir RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in China. N=89
Some concerns
Details

Full description

Novaferon + Lopinavir + Ritonavir Lopinavir + Ritonavir
Novaferon + Lopinavir + Ritonavir Novaferon
ChiCTR2000029851
Zhong M, medRxiv, 2020
Full text
Commentary
Private alfa-Lipoic acid Placebo RCT Patients with confirmed COVID-19 (severe-critical) admitted to 1 center in China. N=17
Some concerns
Details

Full description