Pharmacologic treatments for covid-19 patients

Therapeutic anticoagulant vs Prophylactic anticoagulant

This comparison will not be updated. Last search date 28 Feb, 2022.


Hospitalized patients

Forest plots
(last update: 2022-04-29)

Summary of findings
(last update: 2022-05-04)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=97

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
N/A
Rashidi F, Thromb Res, 2021
Full text
Commentary
Not reported/unclear

tPA

tPA

Therap AC

Therap AC

Prophylactic AC

Prophylactic AC

RCT Patients with confirmed COVID-19 (severe-critical) admitted to 2 centers in Iran. N=15
Some concerns
Details

Full description

0112U001413 (Ukraine)
Oliynyk O, Life, 2021
Full text
Commentary
Public/non profit

Therap LMWH

Prophylactic AC

RCT Patients with confirmed COVID-19 (critical) admitted to a single center in the Ukraine N=126
Some concerns
Details

Full description

NCT04604327
Marcos M, Thromb Haemost, 2021
Full text
Commentary
Commentary
Mixed

Therap AC

Prophylactic AC

RCT Patients with suspected or confirmed COVID-19 (mild-moderate) admitted to 5 centers in Spain. N=65
High
Details

Full description

NCT04401293
Spyropoulos A, JAMA Intern Med, 2021
Full text
Commentary
Commentary
Public/non profit

Therap AC

Intermediate dose

RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 12 centers in the USA N=257
Some concerns
Details

Full description

NCT04362085; NCT04444700
RAPID
Sholzberg M, BMJ, 2021
Full text
Full text
Commentary
Commentary
Commentary
Public/non profit

Therapeutic Heparin

Prophylactic Heparin

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a 28 centers in Brazil, Canada, Ireland, Saudi Arabia, UAE, USA. N=465
Some concerns
Details

Full description

NCT04394377
ACTION
Lopes RD, Lancet , 2021
Full text
01203-4/fulltext Commentary
Commentary
(21)01291-5/fulltext
Mixed

Therap AC

Prophylactic AC

RCT Patients with confirmed COVID-19 (mild-critical) admitted to 31 centers in Brazil N=615
Some concerns
Details

Full description

NCT02735707, NCT04505774, NCT04359277, NCT04372589
Lawler PR, N Engl J Med, 2021
Full text
Full text
Commentary
Mixed

Therap UFH

Prophylactic AC

RCT Patients with confirmed COVID-19 (mild-severe) admitted to 121 centers in Australia, Brazil, Canada, Mexico, Nepal, Netherlands, Spain, UK, USA. N=2244
Some concerns
Details

Full description

NCT02735707, NCT04505774, NCT04359277, NCT04372589
Goligher E, N Engl J Med, 2021
Full text
Full text
Commentary
Mixed

Therap UFH

Prophylactic AC

RCT Patients with confirmed COVID-19 (severe-critical) admitted to 393 centers in Australia, Brazil, Canada, Ireland, Mexico, Netherlands, New Zealand, Saudi Arabia, UK, USA N=1207
Some concerns
Details

Full description

RBR-949z6v
Lemos ACB, Thromb Res, 2020
Full text
Commentary
No specific funding

Therap EX

Prophylactic AC

RCT Patients with confirmed COVID-19 (critical) admitted to a single center in Brazil N=20
Some concerns
Details

Full description