Pharmacologic treatments for covid-19 patients

If you want to see all comparisons, please click here

Corticosteroids vs Standard Care/Placebo

Forest plots were updated on 03-03-2021
The Evidence profile and Summary of Findings table are updated:03-03-2021.

We requested data from three randomized trials evaluating corticosteroids that are yet to be published but were considered in the meta analysis" Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis. We have extracted available data from this systematic review for the three unpublished studies. These have been included in our tables and forest plots.Forest plots

Evidence profile

Summary of findings


Trial Comparisons Design Participants Sample size Overall risk of bias
Primary outcome
Full description
Treatment 1 Treatment 2
NCT04381936
RECOVERY Trial
Horby P, N Engl J Med, 2020
Full text
Commentary
Dexamethasone Standard care RCT Patients with suspected and confirmed COVID-19 (moderate to critical) admitted to 176 centers in the UK N=6425
Some concerns
Details

Full description

Forest plot
(sub group)
NCT04343729
Prado Jeronimo CM, Clin Infect Dis, 2020
Full text
Commentary
Methylprednisolone Placebo RCT Patients with COVID-19 (moderate-critical) admitted to a single center in Brazil N=416
High
Details

Full description

EudraCT202000193437
Corral-Gudino L, medRxiv, 2020
Full text
Commentary
Methylprednisolone Standard care RCT Patients with COVID-19 (severe) admitted to a 5 centers in Spain N=64
High
Details

Full description

NCT02517489
Dequin P-F, JAMA, 2020
Full text
Commentary
Hydrocortisone Placebo RCT Patients with COVID-19 (severe-critical) admitted to 9 centers in France N=149
Low
Details

Full description

NCT04327401
Tomazini BM, JAMA, 2020
Full text
Commentary
Dexamethasone Standard care RCT Patients with suspected or confirmed COVID-19 (critical) admitted to 41 centers in Brazil N=299
Some concerns
Details

Full description

NCT02735707
Angus DC, JAMA, 2020
Full text
Commentary
Fixed-dose hydrocortisone Standard care RCT Patients with COVID-19 (severe-critical) admitted to 121 centers in 8 countries N=251
Some concerns
Details

Full description

IRCT20200406046963N1
Farahani R, Research Square, 2020
Full text
Commentary
IVMP Pulse then Prednisolone Standard care RCT Patients with COVID-19 (severe) admitted to a single center in Iran N=29
*
Details

Full description

IRCT20200404046947N1
Edalatifard M, Eur Respir J, 2020
Full text
Commentary
Intravenous pulse Methylprednisolone Standard care RCT Patients with confirmed COVID-19 (severe) admitted to two centers in Iran N=68
High
Details

Full description

NCT04348305
Perner A, unpublished, 2020
Hydrocortisone Placebo RCT Patients with confirmed COVID-19 (severe-critical) admitted to 19 centers in Denmark. N=29
Low
Details

Full description

NCT04244591
Du, unpublished, 2020
Methylprednisolone Standard care RCT Patients with confirmed COVID-19 (severe-critical) admitted to multiple centers in China N=47
Some concerns
Details

Full description

NCT04325061
Villar J, unpublished, 2020
Unpublished
Dexamethasone Standard care RCT Patients with confirmed COVID-19 (critical) admitted 14 centers in Spain N=19
Low
Details

Full description

NCT04273321
Tang X, Respiration, 2021
Full text
Commentary
Methylprednisolone Placebo RCT Patients with confirmed COVID-19 (moderate/severe) admitted to 7 centers in China. N=86
Some concerns
Details

Full description

Kemran S M medRxiv, 2020 trial was not included in our data analysis due to unconvincing randamization that was not clarified by authors quote " Randomization rules were designed by Dr. xxx together with principal investigators and implemented by an independent statistician who was not involved in data analysis. Stratified random sampling was applied to stratify all eligible patients according to age, gender and comorbidities. Computerized random number generator was used and allocation was done in 2:1 sequence. Cards with each group assignment number randomly generated by computer were placed in sequentially numbered envelopes that were opened as the patients were enrolled".