Pharmacologic treatments for covid-19 patients
Corticosteroids vs Standard Care/Placebo
This comparison will not be updated. Last search date 14 Dec, 2022
We requested data from three randomized trials evaluating corticosteroids that are yet to be published but were considered in the meta analysis" Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis. We have extracted available data from this systematic review for the three unpublished studies. These have been included in our tables and forest plots.
Hospitalized patients
Forest plots
(last update: 2022-12-06)
Funnel plots
(last update: 2021-07-22)
Summary of findings
(last update: 2022-12-06)
To access all information :
- click here for Hospitalized patients
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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=39
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Trial | Funding | Comparisons | Design | Participants | Sample size | Overall risk of bias Highest assessment |
Full description | |
---|---|---|---|---|---|---|---|---|
Treatment 1 | Treatment 2 | |||||||
NCT04438980 ; EudraCT 2020-001827-15 CORTIVID Les I, Front Med, 2022 Full text Commentary Commentary |
Public/non profit |
Intravenous Methylprednisolone pulse |
Placebo |
RCT | Patients with confirmed COVID-19 (moderate) admitted to 2 centers in Spain. | N=72 |
Some concerns Details |
|
NCT04673162 ; EudraCT 2020-004323-16 Salvarani C, Eur Respir J, 2022 Full text Commentary |
No specific funding |
Methylprednisolone |
Placebo |
RCT | Patients with confirmed COVID-19 (moderate-severe) admitted to 19 centers in Italy. | N=304 |
Low Details |
|
NCT03852537 SMART Trial Odeyemi YE, Crit Care, 2022 Full text Commentary |
Public/non profit |
Methylprednisolone |
Standard care |
RCT | Patients with suspected or confirmed COVID-19 (mild to critical) admitted to a single center in the USA. | N=41 |
High Details |
|
NCT04348305 COVID STEROID Munch MW, Acta Anaesthesiol Sc, 2021 Full text Commentary |
Mixed |
Hydrocortisone |
Placebo |
RCT | Patients with confirmed COVID-19 (severe/critical) admitted to 12 centers in Denmark | N=30 |
Low Details |
|
IRCT20151227025726N17 Jamaati H, Eur J Pharmacol, 2021 Full text Commentary |
Public/non profit |
Dexamethasone |
Standard care |
RCT | Patients with confirmed COVID-19 (severe) admitted to a single center in Iran | N=50 |
Some concerns Details |
|
NCT04273321 Tang X, Respiration, 2021 Full text Commentary |
Public/non profit |
Methylprednisolone |
Placebo |
RCT | Patients with confirmed COVID-19 (moderate/severe) admitted to 7 centers in China. | N=86 |
Some concerns Details |
|
NCT04325061 DEXA-COVID19 Villar J, Unpublished, 2020 |
Public/non profit |
Dexamethasone |
Standard care |
RCT | Patients with confirmed COVID-19 (critical) admitted 14 centers in Spain | N=19 |
Low Details |
|
NCT04244591 Steroids-SARI Du, Unpublished, 2020 |
Public/non profit |
Methylprednisolone |
Standard care |
RCT | Patients with confirmed COVID-19 (severe-critical) admitted to multiple centers in China | N=47 |
Some concerns Details |
|
IRCT20200404046947N1 Edalatifard M, Eur Respir J, 2020 Full text Commentary |
Public/non profit |
Intravenous Methylprednisolone pulse |
Standard care |
RCT | Patients with confirmed COVID-19 (severe) admitted to two centers in Iran | N=68 |
Some concerns Details |
|
IRCT20200406046963N1 Farahani R, Research Square, 2020 Full text Commentary |
Public/non profit |
Intravenous Methylprednisolone pulse+Prednisolone |
Standard care |
RCT | Patients with COVID-19 (severe) admitted to a single center in Iran | N=29 | N/A | |
NCT04327401 Tomazini BM, JAMA, 2020 Full text Commentary |
Mixed |
Dexamethasone |
Standard care |
RCT | Patients with suspected or confirmed COVID-19 (critical) admitted to 41 centers in Brazil | N=299 |
Some concerns Details |
|
NCT02735707 REMAP-CAP Angus DC, JAMA, 2020 Full text Commentary |
Public/non profit |
Fixed-dose hydrocortisone |
Standard care |
RCT | Patients with COVID-19 (severe-critical) admitted to 121 centers in 8 countries | N=251 |
Some concerns Details |
|
NCT02517489 Dequin P-F, JAMA, 2020 Full text Commentary |
Public/non profit |
Hydrocortisone |
Placebo |
RCT | Patients with COVID-19 (severe-critical) admitted to 9 centers in France | N=149 |
Some concerns Details |
|
EudraCT202000193437 GLUCOCOVID Corral-Gudino L, medRxiv, 2020 Full text Commentary |
No specific funding |
Methylprednisolone |
Standard care |
RCT | Patients with COVID-19 (severe) admitted to 5 centers in Spain | N=64 |
High Details |
|
NCT04343729 Prado Jeronimo CM, Clin Infect Dis, 2020 Full text Commentary |
Public/non profit |
Methylprednisolone |
Placebo |
RCT | Patients with COVID-19 (moderate-critical) admitted to a single center in Brazil | N=416 |
High Details |
|
NCT04381936 RECOVERY (Dex) Horby P, N Engl J Med, 2021 Full text Commentary |
Mixed |
Dexamethasone |
Standard care |
RCT | Patients with suspected and confirmed COVID-19 (mild-moderate-critical) admitted to 176 centers in the UK | N=6425 |
Some concerns Details |