Pharmacologic treatments for covid-19 patients

Corticosteroids vs Standard Care/Placebo

We requested data from three randomized trials evaluating corticosteroids that are yet to be published but were considered in the meta analysis" Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis. We have extracted available data from this systematic review for the three unpublished studies. These have been included in our tables and forest plots.

Hospitalized patients

Forest plots
(last update: 2022-09-07)

Funnel plots
(last update: 2021-07-22)

Summary of findings
(last update: 2022-09-27)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=39

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04438980 ; EudraCT 2020-001827-15
CORTIVID
Les I, Front Med, 2022
Full text
Commentary
Commentary
Public/non profit

Intravenous Methylprednisolone pulse

Placebo

RCT Patients with confirmed COVID-19 (moderate) admitted to 2 centers in Spain. N=72
Some concerns
Details

Full description

NCT04673162 ; EudraCT 2020-004323-16
Salvarani C, Eur Respir J, 2022
Full text
Commentary
No specific funding

Methylprednisolone

Placebo

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 19 centers in Italy. N=304
Low
Details

Full description

NCT03852537
SMART Trial
Odeyemi YE, Crit Care, 2022
Full text
Commentary
Public/non profit

Methylprednisolone

Standard care

RCT Patients with suspected or confirmed COVID-19 (mild to critical) admitted to a single center in the USA. N=41
High
Details

Full description

NCT04348305
COVID STEROID
Munch MW, Acta Anaesthesiol Sc, 2021
Full text
Commentary
Mixed

Hydrocortisone

Placebo

RCT Patients with confirmed COVID-19 (severe/critical) admitted to 12 centers in Denmark N=30
Low
Details

Full description

IRCT20151227025726N17
Jamaati H, Eur J Pharmacol, 2021
Full text
Commentary
Public/non profit

Dexamethasone

Standard care

RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Iran N=50
Some concerns
Details

Full description

NCT04273321
Tang X, Respiration, 2021
Full text
Commentary
Public/non profit

Methylprednisolone

Placebo

RCT Patients with confirmed COVID-19 (moderate/severe) admitted to 7 centers in China. N=86
Some concerns
Details

Full description

NCT04244591
Steroids-SARI
Du, Unpublished, 2020
Public/non profit

Methylprednisolone

Standard care

RCT Patients with confirmed COVID-19 (severe-critical) admitted to multiple centers in China N=47
Some concerns
Details

Full description

NCT04325061
DEXA-COVID19
Villar J, Unpublished, 2020
Public/non profit

Dexamethasone

Standard care

RCT Patients with confirmed COVID-19 (critical) admitted 14 centers in Spain N=19
Low
Details

Full description

IRCT20200404046947N1
Edalatifard M, Eur Respir J, 2020
Full text
Commentary
Public/non profit

Intravenous Methylprednisolone pulse

Standard care

RCT Patients with confirmed COVID-19 (severe) admitted to two centers in Iran N=68
Some concerns
Details

Full description

IRCT20200406046963N1
Farahani R, Research Square, 2020
Full text
Commentary
Public/non profit

Intravenous Methylprednisolone pulse+Prednisolone

Standard care

RCT Patients with COVID-19 (severe) admitted to a single center in Iran N=29 N/A

Full description

NCT04327401
Tomazini BM, JAMA, 2020
Full text
Commentary
Mixed

Dexamethasone

Standard care

RCT Patients with suspected or confirmed COVID-19 (critical) admitted to 41 centers in Brazil N=299
Some concerns
Details

Full description

NCT02735707
REMAP-CAP
Angus DC, JAMA, 2020
Full text
Commentary
Public/non profit

Fixed-dose hydrocortisone

Standard care

RCT Patients with COVID-19 (severe-critical) admitted to 121 centers in 8 countries N=251
Some concerns
Details

Full description

NCT02517489
Dequin P-F, JAMA, 2020
Full text
Commentary
Public/non profit

Hydrocortisone

Placebo

RCT Patients with COVID-19 (severe-critical) admitted to 9 centers in France N=149
Some concerns
Details

Full description

EudraCT202000193437
GLUCOCOVID
Corral-Gudino L, medRxiv, 2020
Full text
Commentary
No specific funding

Methylprednisolone

Standard care

RCT Patients with COVID-19 (severe) admitted to 5 centers in Spain N=64
High
Details

Full description

NCT04343729
Prado Jeronimo CM, Clin Infect Dis, 2020
Full text
Commentary
Public/non profit

Methylprednisolone

Placebo

RCT Patients with COVID-19 (moderate-critical) admitted to a single center in Brazil N=416
High
Details

Full description

NCT04381936
RECOVERY (Dex)
Horby P, N Engl J Med, 2021
Full text
Commentary
Mixed

Dexamethasone

Standard care

RCT Patients with suspected and confirmed COVID-19 (mild-moderate-critical) admitted to 176 centers in the UK N=6425
Some concerns
Details

Full description