Trial NCT04438980 ; EudraCT 2020-001827-15
Publication CORTIVID - Les I, Front Med (2022) (published paper)
Primary outcome on the report: Treatment failure, defined as death, ICU admission, initiation of MV, or clinical worsening up to 14 days post-randomization. Clinical worsening was considered when at least one of the following two conditions was met: (1) SpO2 in ambient air below 90%, PaO2 in ambient air below 60 mmHg, or PaO2/FiO2 ratio below 300 mmHg; or (2) at least 15% decrease in the PaO2 from baseline, together with an increase in the levels of any inflammatory marker (CRP, IL-6, or ferritin) or radiological progression.

Note: The risk of bias by domain corresponds to the highest risk of bias among outcomes by domain.
The overall risk of bias corresponds to the overall highest risk of bias assessed among outcomes.