Pharmacologic treatments for covid-19 patients

Convalescent plasma vs Standard care/Placebo


Outpatients

Forest plots
(last update: 2022-05-18)

Summary of findings
(last update: 2022-06-01)

Hospitalized patients

Forest plots
(last update: 2022-05-18)

Funnel plots
(last update: 2022-06-27)

Summary of findings
(last update: 2022-05-19)

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04425915
COPLA-II trial
Bajpai M, BMJ Open, 2022
Full text
Commentary
Commentary
No specific funding

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 2 centers in India. N=400
Some concerns
Details

Full description

NCT04405310
Fernandez-Sanchez V, Research Square, 2022
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Placebo

RCT Patients with confirmed COVID-19 (moderate-critical) admitted to two centers in Mexico N=43
Some concerns
Details

Full description

NCT04415086
COOP-COVID-19-MCTI
Song ATW, Lancet Reg Health Am, 2022
Full text
Commentary
Public/non profit

Convalescent plasma 400

Convalescent plasma 200

RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 7 centers in Brazil. N=129
Some concerns
Details

Full description

NCT04621123
Alemany A, Lancet Respir Med, 2022
Full text
Commentary
Commentary
Mixed

Convalescent plasma

Placebo

RCT Outpatients with confirmed COVID-19 (mild-moderate) treated at 4 centers in Spain. N=376
Low
Details

Full description

NCT04516811
PROTECT-Patient
van den Berg K, Sci Rep, 2022
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Placebo

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 4 centers in South Africa. N=103
Low
Details

Full description

RBR-7f4mt9f
De Santis GC, Emerg Infect Dis, 2022
Full text
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (severe-critical) admitted to 5 centers in Brazil N=110
Some concerns
Details

Full description

ISRCTN85216856
Baldeon ME, Transfus Med, 2022
Full text
Commentary
Public/non profit

Convalescent plasma

Placebo

RCT Patients with suspected or confirmed COVID-19 (unclear severity) admitted to 3 centers in Ecuador. N=158
Some concerns
Details

Full description

NCT04364737
CONTAIN COVID-19
Ortigoza MB, JAMA Intern Med, 2021
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Placebo

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 21 centers in the USA. N=941
Some concerns
Details

Full description

NCT04600440
Holm K, BMC Res Notes, 2021
Full text
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (moderate-critical) admitted to 2 centers in Sweden. N=33
Some concerns
Details

Full description

NCT04589949, NCT04621123
COMPILE home
Millat-Martinez P, medRxiv, 2021
Full text
Commentary
Commentary
Mixed

Convalescent plasma

Placebo

RCT Outpatients with confirmed COVID-19 (mild, symptomatic) treated by 14 centers in Spain and the Netherlands. N=797
Some concerns
Details

Full description

NCT04397757
PennCCP2
Bar KJ, J Clin Invest, 2021
Full text
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (mild-severe) admitted to 2 centers in the USA. N=80
Some concerns
Details

Full description

NCT04373460
Sullivan D, N Engl J Med, 2022
Full text
Full text
Commentary
Commentary
Commentary
Mixed

Convalescent plasma

Placebo

RCT Outpatients (symptomatic, mild) with confirmed COVID-19 treated at 23 centers in the USA. N=1225
Low
Details

Full description

NCT04716556
TSUNAMI
Menichetti F , JAMA, 2021
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 27 centers in Italy. N=487
Some concerns
Details

Full description

NCT04355767
SIREN-C3PO
Korley F, N Engl J Med, 2021
Full text
rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Commentary
Public/non profit

Convalescent plasma

Placebo

RCT Outpatients and patients with confirmed COVID-19 (symptomatic, mild to moderate) treated at or admitted to 48 centers in the USA. N=511
Low
Details

Full description

NCT04542941
Kirenga B, BMJ Open Respir Res, 2021
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (asymptomatic-severe) admitted to a single center in Uganda. N=136
Some concerns
Details

Full description

NCT04547660
PLACOVID
Sekine L, Eur Respir J, 2021
Full text
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (moderate-critical) admitted to a single center in Brazil. N=160
Some concerns
Details

Full description

NCT04348656
CONCOR-1
Begin P, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to 72 centers in Canada, USA and Brazil. N=940
Some concerns
Details

Full description

NCT02735707
REMAP-CAP
Estcourt L, JAMA, 2021
Full text
Full text
Commentary
Commentary
Mixed

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (severe-critical) admitted to 129 centers in Australia, Canada, UK, USA N=2000
Low
Details

Full description

NCT04433910; EudraCT 2020-001310-38
CAPSID
Koerper S, J Clin Invest, 2021
Full text
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (mild-critical) admitted to 13 centers in Germany. N=105
Some concerns
Details

Full description

IRCT20200310046736N1
Pouladzadeh M, Intern Emerg Med, 2021
Full text
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (severe-critical) admitted to a single center in Iran N=62
Some concerns
Details

Full description

NCT04381936; EudraCT 2020-001113-21; ISRCTN5018967
RECOVERY-CP
Horby P, Lancet, 2021
Full text
Commentary
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with suspected or confirmed COVID-19 (mild-moderate-severe-critical) admitted to 177 centers in the UK. N=11558
Some concerns
Details

Full description

N/A
Rasheed A, Le Infezioni in Medi, 2020
Full text
Public/non profit

Convalescent plasma

Standard care

RCT Patients with COVID-19 (severe) admitted to 3 centers in Iraq. N=49 N/A

Full description

NCT04530370
Salman OH, Egypt J Anaesth, 2020
Full text
Commentary
Not reported/unclear

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Egypt N=30
Some concerns
Details

Full description

NCT04383535
PlasmAr
Simonovich VA, N Engl J Med, 2020
Full text
Commentary
Mixed

Convalescent plasma

Placebo

RCT Patients with confirmed COVID-19 (severe) admitted to 12 centers in Argentina N=334
Some concerns
Details

Full description

CTRI/2020/05/025209
Ray Y, Nat Commun, 2022
Full text
Full text
Commentary
Commentary
Commentary
Public/non profit

Convalescent plasma

Standard care

RCT Patients with confirmed COVID-19 (severe) admitted to a single center in India. N=80
High
Details

Full description