Pharmacologic treatments for covid-19 patients

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Convalescent plasma vs Standard care/Placebo

Forest plots were updated on 04-02-2021.
The Evidence profile and Summary of findings table are updated on 26-02-2021. Forest plots

Evidence profile

Summary of findings


Trial Comparisons Design Participants Sample size Overall risk of bias
Primary outcome
Full description
Treatment 1 Treatment 2
ChiCTR2000029757
Li L, JAMA, 2020
Full text
Commentary
Commentary
Convalescent plasma Standard care RCT Patients with COVID-19 (severe to critical) admitted to 7 centers in China. N=103
Some concerns
Details

Full description

NCT04342182
Gharbharan A, medRxiv, 2020
Full text
Convalescent plasma Standard care RCT Patients with COVID-19 (moderate-critical) admitted to 14 centers in the Netherlands N=86
High
Details

Full description

NCT04345523
Avendano-Sola C, medRxiv, 2020
Full text
Commentary
Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (moderate) admitted to 14 centers in Spain N=81
Some concerns
Details

Full description

CTRI/2020/04/024775
Agarwal A, BMJ, 2020
Full text
Commentary
Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (mild to severe) admitted to 39 centers in India. N=464
High
Details

Full description

NCT04356534
AlQahtani M, medRxiv, 2020
Full text
Commentary
Commentary
Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to 2 centers in Bahrain N=40
Some concerns
Details

Full description

NCT04479163
Libster R, NEJM, 2021
Full text
Commentary
Convalescent plasma Placebo RCT Patients with confirmed COVID-19 (mild) admitted to multiple centers in Argentina N=160
Low
Details

Full description

NCT04383535
Simonovich VA, N Engl J Med, 2020
Full text
Commentary
Convalescent plasma Placebo RCT Patients with confirmed COVID-19 (severe) admitted to 12 centers in Argentina N=334
Some concerns
Details

Full description

CTRI/2020/05/025209
Ray Y, medRxiv, 2020
Full text
Commentary
Commentary
Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in India N=80
High
Details

Full description

new
N/A
Rasheed A, Le Infezioni in Medicina, 2020
Full text
Convalescent plasma Standard care RCT Patients with COVID-19 (severe) admitted to 3 centers in Iraq. N=49
*
Details

Full description

new
NCT04530370
Salman OH, Egypt J Anaesth, 2020
Full text
Commentary
Convalescent plasma Standard care RCT Patients with confirmed COVID-19 (severe) admitted to a single center in Egypt N=30
Some concerns
Details

Full description

Kemran S M medRxiv, 2020 trial was not included in our data analysis due to unconvincing randamization that was not clarified by authors quote " Randomization rules were designed by Dr. xxx together with principal investigators and implemented by an independent statistician who was not involved in data analysis. Stratified random sampling was applied to stratify all eligible patients according to age, gender and comorbidities. Computerized random number generator was used and allocation was done in 2:1 sequence. Cards with each group assignment number randomly generated by computer were placed in sequentially numbered envelopes that were opened as the patients were enrolled".