Publication COOP-COVID-19-MCTI - Song ATW, Lancet Reg Health Am (2022) (published paper)
Dates: 2020-06-02 to 2020-11-18
Funding: Public/non profit (Brazilian Ministry of Science, Technology and Innovation, Fundação de Amparo à Pesquisa do Estado de São Paulo.)
Conflict of interest: No
Multicenter / Brazil |
Follow-up duration (days): 28
Convalescent plasma 400
400 mL (range 300−600 mL) once-off administered within 24 h after randomization and could be split in two stages within 24 h. The plasma infusion lasted up to 1 h.
Convalescent plasma 200
200 mL (range 150−300 mL) once-off administered within 24 h after randomization. The plasma infusion lasted up to 1 h.
Convalescent plasma 400 =44
Convalescent plasma 200 =43
|Characteristics of participants|
Mean age : NR
Severity : Mild: n=0 / Moderate: n=* / Severe: n=* Critical: n=*
Number of vaccinated participants: 0
|In the register|
Time elapsed until clinical improvement or hospital discharge [ Time Frame: Follow up until 28 days after transfusion ] clinical improvement is defined as the time from the randomization date until the decline of 2 categories on the ordinal scale of 10 categories or hospital discharge (whichever comes first).
|In the report|
Time to clinical improvement at day 28, defined as the number of days from randomization to the first decline of at least two categories on the World Health Organization's ordinal progression scale or hospital discharge, whichever came first
Data-sharing willing stated in the publication:
|Risk of bias
The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review
|General comment||In addition to the published article, the trial registry and statistical analysis plan/protocol were used in data extraction and assessment of risk of bias. Supplementary appendices referred to in the article were not available through the journal website as stated. The primary outcome in the article reflects that in the registry. The trial (n = 129) achieved its target sample size (n = 120).|