COVID-19 vaccine effectiveness
(Randomized evidence)

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Search by Vaccine name Author Registration number
Trial Type Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Intervention 1 Intervention 2
NCT04649151
ModernaTX
Ali K, N Engl J Med, 2021 ()

Full text
Commentary
RNA based vaccine

mRNA-1273

Placebo

RCT
Phase 2-3
Healthy adolescents in 26 centers in the USA N=3732
Some concerns
Details

Full description

NCT04470427
ModernaTX
El Sahly HM, N Engl J Med, 2021 ()
COVE

Full text
Commentary
RNA based vaccine

mRNA-1273 100 mcg D1/28

Placebo D1/28

RCT
Phase 3
Healthy adults with no known history of SARS-CoV-2 infection in 99 centers in the US N=30415
Some concerns
Details

Full description

NCT04677660
ModernaTX
Masuda T, Vaccine, 2022

Full text
Commentary
RNA based vaccine

mRNA-1273

Placebo

RCT
Phase 1-2
Healthy adults aged ≥ 20 years with no known history/risk of SARS-CoV-2 infection at 2 centers in Japan. N=200
Some concerns
Details

Full description