Weekly Update

Weekly Update: April 12th to April 16th, 2021

New RCTs available

7 new RCTs with results are available on our website: see here for vaccine et here for treatment

Alavi-moghaddam M, SSRN, 2021 Safety and Efficacy of Sofosbuvir in Hospitalized Adult Patients with SARS-CoV-2: A Preliminary Report
Barratt-Due A, SSRN, 2021 Evaluation of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 Patients: Results from the NOR-Solidarity Randomised Trial
Butler C, Lancet , 2021 Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
Mobarak S, SSRN, 2021 Evaluation of the Effect of Sofosbuvir and Daclatasvir in Hospitalised COVID-19 Patients: A Randomized Double-Blind Clinical Trial (DISCOVER)
Pandit A, Int J Infect Dis, 2021 Efficacy and Safety of Pegylated Interferon alfa-2b in Moderate COVID-19: A phase II, randomized, controlled, open-label study.
Singh D, medRxiv, 2021 A phase 2 study of the inhaled pan-JAK inhibitor TD-0903 in severe COVID-19: Part 1
Solaymani-Dodaran M, Int Immunopharmacol, 2021 Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia.

RCTs pending data extraction

26 new pharmacological and/or preventive RCTs:

Kishoria N, 2020 IVERMECTIN AS ADJUVANT TO HYDROXYCHOLOROQUINE IN PATIENTS RESISTANT TO STANDARD TREATMENT FOR SARS-CoV-2: RESULTS OF AN OPEN-LABEL RANDOMIZED CLINICAL STUDY
Amra B, ResearchSquare, 2021 Thalidomide for the treatment of severe Covid-19: A randomized clinical trial
Bundgaard H, Ann Intern Med. 2020 Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers
Chahla RE, medRxiv, 2021 A RANDOMIZED TRIAL - INTENSIVE TREATMENT BASED IN IVERMECTIN AND IOTA-CARRAGEENAN AS PRE-EXPOSURE PROPHYLAXIS FOR COVID- 19 IN HEALTHCARE AGENTS
Ghaderkhani S, ResearchSquare, 2021 Efficacy and Safety of Arbidol in Treatment of Patients with COVID-19 Infection: A Randomized Clinical Trial
Ghahremani M, ResearchSquare, 2021 Exogenous Surfactant Versus Placebo in the Treatment of Moderate and Severe ARDS in COVID-19: The Pilot Study of a Clinical Trial
Ghati N, SSRN, 2021 A Randomis ed Control Trial of Statin and Asp irin as Adjuvant Therapy in Patients with SARS-CoV-2 Infec tion (RESIST Trial)
Grieco DL, JAMA, 2021 Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial.
Hadanny A, SSRN, 2021 Hyperbaric Oxygen Therapy for COVID-19 Patients: A Prospective, Randomized Controlled Trial
JayakumarD, medRxiv, 2021 Awake prone position in adult nonintubated patients with acute hypoxaemic respiratory failure secondary to COVID-19:A multi-centre feasibility randomized controlled trial
Johnston C, SSRN, 2021 Hydroxychloroquine with or Without Azithromycin for Treatment of Early SARS-CoV-2 Infection Among High-Risk Outpatient Adults: A Randomized Clinical Trial
Kamran SM, Cureus, 2021 Clearing the Fog: Is Hydroxychloroquine Effective in Reducing Coronavirus Disease-2019 Progression? A Randomized Controlled Trial
Kharat A, SSRN, 2020 Self-Proning in COVID-19 Patients on Low-Flow Oxygen Therapy: A Cluster Randomised Controlled Trial
Lin YR, J Aerosol Med Pulm Drug Deliv, 2021 Mycobacterium vaccae Nebulization in the Treatment of COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial.
Mahajan L, Indian J Anaesth, 2021 Clinical outcomes of using remdesivir in patients with moderate to severe COVID-19: A prospective randomised study.
Mikhaylov E, medRxiv, 2021 Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study
Papachristofilou A, Int J Radiat Oncol Biol Phys, 2021 Low dose radiation therapy for severe COVID-19 pneumonia: a randomized double-blind study.
Patel O, J. Med. Virol, 2021 A pilot double-blind safety and feasibility randomised controlled trial of high-dose intravenous zinc in hospitalised COVID-19 patients.
Perlin DS, medRxiv, 2021 CERC-002, a human anti-LIGHT mAb reduces respiratory failure and death in hospitalized COVID-19 ARDS patients
Pouladzadeh M, Intern Emerg Med, 2021 A randomized clinical trial evaluating the immunomodulatory effect of convalescent plasma on COVID-19-related cytokine storm.
Puskarich M, SSRN, 2021 Effect of Losartan on Symptomatic Outpatients with COVID-19: A Randomized Clinical Trial
Rasheed A, Le Infezioni in Medicina, 2020 The therapeutic potential of convalescent plasma therapy on treating critically-ill COVID-19 patients residing in respiratory care units in hospitals in Baghdad, Iraq
Sheng C, Clin Cardiol. 2020 Canakinumab to Reduce Deterioration of Cardiac and Respiratory Function in Sars-cov2 Associated Myocardial Injury With Heightened Inflammation (canakinumab in Covid-19 Cardiac Injury): Results From the Randomized Three C Study
Vetrici MA, J Inflamm Res, 2021 Evaluation of Adjunctive Photobiomodulation (PBMT) for COVID-19 Pneumonia via Clinical Status and Pulmonary Severity Indices in a Preliminary Trial.
Youssef J, SSRN, 2021 Effectiveness of ZYESAMIâ„¢ (Aviptadil) in Accelerating Recovery and Shortening Hospitalization in Critically-Ill Patients with COVID-19 Respiratory Failure: Interim Report from a Phase 2B/3 Multicenter Trial
Yu LM, medRxiv, 2021 Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial

6 new vaccine RCTs:

Bueno S, medRxiv, 2021 Interim Report: Safety And Immunogenicity Of An Inactivated Vaccine Against Sars-Cov-2 In Healthy Chilean Adults In A Phase 3 Clinical Trial
Goepfert P, medRxiv, 2021 Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: a randomised, placebo-controlled, dose-ranging study
Han B, SSRN, 2021 Safety, Tolerability and Immunogenicity of an Inactivated SARS-CoV-2 Vaccine (CoronaVac) in Healthy Children and Adolescents: A Randomised, Double-Blind, and Placebo-Controlled, Phase 1/2 Clinical Trial
Palacios R, SSRN, 2021 Efficacy and Safety of a COVID-19 Inactivated Vaccine in Healthcare Professionals in Brazil: The PROFISCOV Study
Pan HX, medRxiv, 2021 Immunogenicity and Safety of a SARS-CoV-2 Inactivated Vaccine (KCONVAC) in Healthy Adults: Two Randomized, Double-blind, and Placebo-controlled Phase 1/2 Clinical Trials
Shinde V, medRxiv, 2021 Preliminary Efficacy of the NVX-CoV2373 Covid-19 Vaccine Against the B.1.351 Variant

RCTs of long covid and psychological disorder identified not extracted

In addition to 11 RCT evaluating Non-pharmacological interventions and long COVID treatments included and pending extraction:

Abdelalim A, Am J Otolaryngol, 2021 Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial
Abdelmaksoud AA, Biol Trace Elem Res, 2021 Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc
Al-Alawi M, JMIR Mental Health, 2021 Efficacy of a six-week-long therapist-guided online therapy versus self-help internet-based therapy for COVID-19 induced anxiety and depression: Open-label, pragmatic, randomized controlled trial
Kong X, Front Psychiatry, 2020 Effect of Psychological-Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients
Li J, Front Psychiatry, 2020 The Effect of Cognitive Behavioral Therapy on Depression, Anxiety, and Stress in Patients With COVID-19: A Randomized Controlled Trial.
Nambi G, ResearchSquare, 2020 Low or Moderate Intensity Aerobic Training: Its Role in Clinical and Psychological Aspects of Community Dwelling COVID-19 Asymptomatic Older Adults With Sarcopenia Symptoms
Shaygan M, ResearchSquare, 2020 The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial
Sotoudeh H.G, Iran J Psychiatry, 2020 The Effect of Brief Crisis Intervention Package on Improving Quality of Life and Mental Health in Patients with COVID-19.
Vaira LA, Rhinology, 2020 Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients.
Wu X, Neuropsychiatry, 2020 Application of Psychological Support Therapy in the Treatment of Patients with COVID-19 Complicated With Emotional Disorders: A Randomized Controlled Trial
Zhao Z, Research Square, 2020 A Randomized Controlled Study of Muscle Training Exercise Based Pulmonary Rehabilitation on Activity of Daily Living in Patients with Coronavirus Disease 2019