Weekly Update

Weekly Update: July 26 to July 30, 2021

New RCTs with results available

8 new RCTs with results are available on our website: see here for vaccine et here for treatment

Alavi Darazam I, Int Immunopharmacol, 2021 Umifenovir in hospitalized moderate to severe COVID-19 patients: A randomized clinical trial.
Arabi Y, Intensive Care Med, 2021 Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.
Caricchio R, JAMA, 2021 Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID-19: A Randomized Clinical Trial.
Dougan M, N Engl J Med, 2021 Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19.
Ella R, medRxiv, 2021 Efficacy, safety, and lot to lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): a double-blind, randomised, controlled phase 3 trial
Liao Y, Emer Microbes Infec, 2021 Safety and immunogenicity of a recombinant interferon-armed RBD dimer vaccine (V-01) for COVID-19 in healthy adults: A randomised, double-blind, placebo-controlled, phase I trial.
Oldenburg CE, JAMA, 2021 Effect of Oral Azithromycin vs Placebo on COVID-19 Symptoms in Outpatients With SARS-CoV-2 InfectionA Randomized Clinical Trial
Parienti JJ, EClinicalMedicine, 2021 Effect of Tenofovir Disoproxil Fumarate and Emtricitabine on nasopharyngeal SARS-CoV-2 viral load burden amongst outpatients with COVID-19: A pilot, randomized, open-label phase 2 trial

RCTs pending data extraction

15 new pharmacological and/or preventive RCTs:

Asadipooya K, SSRN, 2021 A Randomized Single Blind Controlled Trial of Combination Therapy (Spironolactone and Sitagliptin) in Hospitalized Adult Patients with Covid-19
El-Bendary M, Expert Rev Anti-Infe, 2021 Efficacy of combined Sofosbuvir and Daclatasvir in the treatment of COVID-19 patients with pneumonia: a multicenter Egyptian study.
Gaitan-Duarte H, medRxiv, 2021 Effectiveness of Rosuvastatin plus Colchicine, Emtricitabine/Tenofovir and a combination of them in Hospitalized Patients with SARS Covid-19
Kalantari S, J Med Virol, 2021 Comparing the effectiveness of Atazanavir/Ritonavir/Dolutegravir/Hydroxychloroquine and Lopinavir/Ritonavir/Hydroxychloroquine treatment regimens in COVID-19 patients.
Kosiborod M, Lancet Diabetes Endo, 2021 Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial
Labhardt N, SSRN, 2021 Efficacy of Lopinavir-Ritonavir Prophylaxis for Individuals Exposed to SARS-CoV-2: The COPEP Pragmatic Open-Label, Cluster Randomized Trial
Najmeddin F, Am J Hypertens, 2021 Effects of Renin-Angiotensin-Aldosterone Inhibitors on Early Outcomes of Hypertensive COVID-19 Patients: A Randomized Triple-Blind Clinical Trial.
Perner A, medRxiv, 2021 Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial
Rajan R, medRxiv, 2021 Use of Indomethacin for mild and moderate Covid -19 patients. A Randomized Control Trial
Ravikirti N, J Pharm Pharm Sci, 2021 Evaluation of Ivermectin as a Potential Treatment for Mild to Moderate COVID-19: A Double-Blind Randomized Placebo Controlled Trial in Eastern India.
Resende GG, medRxiv, 2021 Blockade of Interleukin Seventeen (IL-17A) with Secukinumab in Hospitalized COVID-19 patients - the BISHOP study.
Santamarina MG, SSRN, 2021 Sildenafil for the Treatment of Patients With COVID-19 and Perfusion Mismatch on Subtraction Computed Tomography Angiography: A Pilot, Placebo-Controlled Randomised Trial
Sekine L, Eur Respir J, 2021 Convalescent plasma for COVID-19 in hospitalised patients: an open-label, randomised clinical trial.
Sholzberg M, medRxiv, 2021 Heparin for Moderately Ill Patients with Covid-19
Wolak T, Am J Respir Crit Care Med, 2021 Inhaled nitric oxide for the treatment of COVID-19 and other viral pneumonias in adults

6 new vaccine RCTs:

Hsieha SM, EClinicalMedicine, 2021 Safety and immunogenicity of a Recombinant Stabilized Prefusion SARS-CoV-2 Spike Protein Vaccine (MVCCOV1901) Adjuvanted with CpG 1018 and Aluminum Hydroxide in healthy adults: A Phase 1, dose-escalation study
Low JG, medRxiv, 2021 A phase 1/2 randomized, double-blinded, placebo controlled ascending dose trial to assess the safety, tolerability and immunogenicity of ARCT-021 in healthy adults
Meng FY, SIGNAL TRANSDUCT TAR, 2021 Safety and immunogenicity of a recombinant COVID-19 vaccine (Sf9 cells) in healthy population aged 18 years or older: two single-center, randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials.
Nguyen T, medRxiv, 2021 Safety and Immunogenicity of Nanocovax, a SARS-CoV-2 Recombinant Spike Protein Vaccine
Wanshen G, EclinicalMedicine, 2021 Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18 years or older: A randomized, double-blind, placebo-controlled, phase 1/2 trial
Wu S, Lancet Infect Dis, 2021 Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

RCTs identified not extracted

In addition to 16 RCT evaluating disorder and long COVID treatments included and pending extraction:

Abdelalim A, Am J Otolaryngol, 2021 Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial
Abdelmaksoud AA, Biol Trace Elem Res, 2021 Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc
Al-Alawi M, JMIR Mental Health, 2021 Efficacy of a six-week-long therapist-guided online therapy versus self-help internet-based therapy for COVID-19 induced anxiety and depression: Open-label, pragmatic, randomized controlled trial
D'Ascanio L, Eur Rev Med Pharmacol Sci, 2021 Randomized clinical trial "olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin": preliminary results.
Fan Y, J Affect Disord, 2021 The effects of narrative exposure therapy on COVID-19 patients with post-traumatic stress symptoms: A randomized controlled trial.
Kong X, Front Psychiatry, 2020 Effect of Psychological-Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients
Kutashov V.A., Neurology, Neuropsychiatry, Psychosomatics. 2021 Actovegin use in patients with cognitive impairment after coronavirus infection (COVID-19)
Li J, Front Psychiatry, 2020 The Effect of Cognitive Behavioral Therapy on Depression, Anxiety, and Stress in Patients With COVID-19: A Randomized Controlled Trial.
Liu Y, Psychol Health Med, 2021 Effects of group psychological intervention combined with pulmonary rehabilitation exercises on anxiety and sleep disorders in patients with mild coronavirus disease 2019 (COVID-19) infections in a Fangcang hospital.
Nambi G, ResearchSquare, 2020 Low or Moderate Intensity Aerobic Training: Its Role in Clinical and Psychological Aspects of Community Dwelling COVID-19 Asymptomatic Older Adults With Sarcopenia Symptoms
Rashid RA, Am J Otolaryngol, 2021 Effect of nasal corticosteroid in the treatment of anosmia due to COVID-19: A randomised double-blind placebo-controlled study.
Shaygan M, ResearchSquare, 2020 The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial
Sotoudeh H.G, Iran J Psychiatry, 2020 The Effect of Brief Crisis Intervention Package on Improving Quality of Life and Mental Health in Patients with COVID-19.
Vaira LA, Rhinology, 2020 Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients.
Wu X, Neuropsychiatry, 2020 Application of Psychological Support Therapy in the Treatment of Patients with COVID-19 Complicated With Emotional Disorders: A Randomized Controlled Trial
Zhao Z, Research Square, 2020 A Randomized Controlled Study of Muscle Training Exercise Based Pulmonary Rehabilitation on Activity of Daily Living in Patients with Coronavirus Disease 2019

In addition to 4 RCT evaluating other non-pharmacological interventions:

Gutierrez-Castrellon P, medrxiv, 2021 Efficacy and safety of novel probiotic formulation in adult Covid19 outpatients: a randomized, placebo-controlled clinical trial
Hamidi-Alamdari D, Rev Invest Clin, 2021 METHYLENE BLUE FOR TREATMENT OF HOSPITALIZED COVID-19 PATIENTS: A RANDOMIZED, CONTROLLED, OPEN-LABEL CLINICAL TRIAL, PHASE 2.
Sehgal I, ERJ Open Res, 2021 A randomised trial of Mycobacterium w in critically ill patients with COVID-19 (ARMY-1)
Supady A, Lancet Respir Med, 2021 May Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial.

In addition to 1 RCT evaluating other non COVID-19 vaccines:

Tsilika M, medrxiv, 2021 ACTIVATE-2: A DOUBLE-BLIND RANDOMIZED TRIAL OF BCG VACCINATION AGAINST COVID19 IN INDIVIDUALS AT RISK