Weekly Update

Weekly Update: February 15 to February 19, 2021

We identify and now report 10 new studies with results available on our website :

Elgazzar A, ResearchSquare, 2020 Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic
Ella R, 2021 Safety and immunogenicity clinical trial of an inactivated SARS-CoV-2 vaccine, BBV152 (a phase 2, double-blind, randomised controlled trial) and the persistence of immune responses from a phase 1 follow-up report
Gottlieb R, JAMA, 2021 Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
Logunov D, Lancet, 2021 Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia
Mohan A , ResearchSquare, 2021 Ivermectin in mild and moderate COVID-19 (RIVET-COV): a randomized, placebo-controlled trial
Roostaei A, ResearchSquare, 2021 Efficacy and Safety of Levamisole Treatment in Clinical Presentations of Patients With COVID-19: A Double-Blind, Randomized, Controlled Trial
Sedighiyan M, Authorea, 2021 Omega-3 polyunsaturated fatty acids supplementation improve clinical symptoms in patients with covid-19: A randomized clinical trial
Tardif JC, medRxiv, 2021 Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19
Ward BJ, medRxiv, 2020 Phase 1 trial of a Candidate Recombinant Virus-Like Particle Vaccine for Covid-19 Disease Produced in Plants
Wu Z, Lancet, 2021 Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial.

We have also included and presently extracting 28 new pharmacological and/or preventive RCTs:

Bundgaard H, Ann Intern Med. 2020 Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers
Cadegiani F, Cureus, 2021 Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Bioch
Cadegiani F, medRxiv, 2020 5-Alpha-Reductase Inhibitors Reduce Remission Time of COVID-19: Results From a Randomized Double Blind Placebo Controlled Interventional Trial in 130 SARS-CoV-2 Positive Men.
Cadegiani F, ResearchSquare, 2021 Proxalutamide (GT0918) Reduces the Rate of Hospitalization and Death in COVID-19 Male Patients: A Randomized Double-Blinded Placebo-Controlled Trial.
Cadegiani FA, Research Square, 2020 Dutasteride Reduces Viral Shedding, Inflammatory Responses and Time-to-Remission in COVID-19: Biochemical Findings of a Randomized Double-Blind Placebo Controlled Interventional Trial (DUTA AndroCoV-Trial - Biochemical).
Dabbous H, Arch Virol, 2021 Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized study
Darazam I, ResearchSquare, 2021 Role of Interferon Therapy in Severe COVID-19: The COVIFERON Randomized Controlled Trial
Darazam I, ResearchSquare, 2021 An Investigation Into the Beneficial Effects of High-Dose Interferon beta 1-a, Compared to Low-Dose Interferon Beta 1-a (the base therapeutic regimen) in moderate to severe COVID-19
Fontanesi Blum, SSRN, 2021 Nitazoxanide In Vitro Efficacy Against SARS CoV-2 and In Vivo Superiority to Placebo to Treat Moderate COVID-19 – A Phase 2 Randomized Double-Blind Clinical Trial
Ghahremani M, ResearchSquare, 2021 Exogenous Surfactant Versus Placebo in the Treatment of Moderate and Severe ARDS in COVID-19: The Pilot Study of a Clinical Trial
Holubovska O, medRxiv, 2021 Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial
Johnston C, SSRN, 2021 Hydroxychloroquine with or Without Azithromycin for Treatment of Early SARS-CoV-2 Infection Among High-Risk Outpatient Adults: A Randomized Clinical Trial
Lopardo G, SSRN, 2021 RBD-Specific Polyclonal F(ab´)
Ramakrishnan S, medRxiv, 2021 Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial
Ranjbar K, ResearchSquare, 2021 Methylprednisolone or Dexamethasone, Which One Is the Superior Corticosteroid in the Treatment of Hospitalized COVID-19 Patients: A Triple-Blinded Randomized Controlled Trial
Rashad A, ResearchSquare, 2021 Therapeutic efficacy of macrolides in management of patients with mild COVID-19
Sali S, Novelty in Biomedicine, 2021 Comparison of the Efficacy of Sofosbuvir and Kaletra on Outcome of Covid-19. Is Sofosbuvir A Potential Treatment For COVID-19?
Shah Bukhari K H, medRxiv, 2021 Efficacy of Ivermectin in COVID-19 Patients with Mild to Moderate Disease
Shouman W, J Clin Diagn Res, 2021 Use of Ivermectin as a potential chemoprophylaxis for COVID-19 in Egypt : A Randomised clinical trial
Tang X, Respiration, 2021 Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial.
Thakar A, Indian J Med Res, 2021 Chloroquine nasal drops in asymptomatic & mild COVID-19: An exploratory randomized clinical trial.
Thomas S, JAMA Netw Open, 2021 Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial.
Tornling G, medRxiv, 2021 The angiotensin type 2 receptor agonist C21 restores respiratory function in COVID19 - a double-blind, randomized, placebo-controlled Phase 2 trial
Torres-Zambrano GM, medRxiv, 2020 Renal Involvement in patients with COVID-19 Pneumonia and Outcomes after Stem Cell Nebulization
Wu X, Neuropsychiatry, 2020 Application of Psychological Support Therapy in the Treatment of Patients with COVID-19 Complicated With Emotional Disorders: A Randomized Controlled Trial
 Khalili H, Acta Biomed, 2020 Efficacy and safety of sofosbuvir/ ledipasvir in treatment of patients with COVID-19

We have also included and presently extracting 4 new vaccine RCTs:

Chappell K, SSRN, 2021 First Report of a Phase 1 Randomised Trial of Molecular Clamp-Stabilised Spike Protein-Based and MF59-Adjuvanted Vaccine for SARS-CoV-2
Emary, SSRN, 2021 Efficacy of ChAdOx1 nCoV-19 (AZD1222) Vaccine Against SARS-CoV-2 VOC 202012/01 (B.1.1.7)
FDA breifing document Ad26.COV2.S (COVID-19) Vaccine Janssen Ad26.COV2.S Vaccine for the Prevention of COVID-19
Yang S, medRxiv, 2020 Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD protein vaccine against COVID-19 in adults: pooled analysis of two randomized, double-blind, placebo-controlled, phase 1 and 2 trials

In addition to 10 RCT evaluating Non-pharmacological interventions and long COVID treatments included and pending extraction:

Abdelalim A, Am J Otolaryngol, 2021 Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial
Abdelmaksoud AA, Biol Trace Elem Res, 2021 Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc
Kharat A, SSRN, 2020 Self-Proning in COVID-19 Patients on Low-Flow Oxygen Therapy: A Cluster Randomised Controlled Trial
Kong X, Front Psychiatry, 2020 Effect of Psychological–Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients
Li J, Front Psychiatry, 2020 The Effect of Cognitive Behavioral Therapy on Depression, Anxiety, and Stress in Patients With COVID-19: A Randomized Controlled Trial.
Nambi G, ResearchSquare, 2020 Low or Moderate Intensity Aerobic Training: Its Role in Clinical and Psychological Aspects of Community Dwelling COVID-19 Asymptomatic Older Adults With Sarcopenia Symptoms
Shaygan M, ResearchSquare, 2020 The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial
Sotoudeh H.G, Iran J Psychiatry, 2020 The Effect of Brief Crisis Intervention Package on Improving Quality of Life and Mental Health in Patients with COVID-19.
Vaira LA, Rhinology, 2020 Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients.
Zhao Z, Research Square, 2020 A Randomized Controlled Study of Muscle Training Exercise Based Pulmonary Rehabilitation on Activity of Daily Living in Patients with Coronavirus Disease 2019