Weekly Update

Weekly Update: May 3 to May 7, 2021

New RCTs available

9 new RCTs with results are available on our website: see here for vaccine et here for treatment

Bosaeed M, SSRN, 2021 Favipiravir and Hydroxychloroquine Combination Therapy in Patients with Moderate to Severe COVID-19 (FACCT): An Open-Label, Multicentre, Randomised, Controlled Trial
Javaherian M, medRxiv, 2021 Safety and efficacy of Pulmonary physiotherapy in hospitalized patients with severe COVID-19 pneumonia (PPTCOVID): A prospective, randomised, single-blind, controlled trial
JayakumarD, medRxiv, 2021 Awake prone position in adult nonintubated patients with acute hypoxaemic respiratory failure secondary to COVID-19:A multi-centre feasibility randomized controlled trial
Marconi V, medRxiv, 2021 Baricitinib plus Standard of Care for Hospitalized Adults with COVID-19
Papachristofilou A, Int J Radiat Oncol Biol Phys, 2021 Low dose radiation therapy for severe COVID-19 pneumonia: a randomized double-blind study.
Rashad A, Scientific Reports, 2021 Short term survival of critically ill COVID-19 Egyptian patients on assisted ventilation treated by either Dexamethasone or Tocilizumab.
Rea-Neto A, Sci Rep, 2021 An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients.
Rosen J, Research Square, 2021 Awake Prone Positioning in Patients with Hypoxemic Respiratory Failure Due to COVID-19: The PROFLO Multicenter Randomized Clinical Trial
Zhao H, Int Immunopharmacol, 2021 Favipiravir in the treatment of patients with SARS-CoV-2 RNA recurrent positive after discharge: a multicenter, open-label, randomized trial

RCTs pending data extraction

14 new pharmacological and/or preventive RCTs:

Fragoso-Saavedra S, medRxiv, 2021 Pyridostigmine in adults with severe SARS-CoV-2 infection: the PISCO trial
Ghahremani M, ResearchSquare, 2021 Exogenous Surfactant Versus Placebo in the Treatment of Moderate and Severe ARDS in COVID-19: The Pilot Study of a Clinical Trial
Gunst JD, EClinicalMedicine, 2021 Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.
Hinks T, SSRN, 2021 A Randomised Clinical Trial of Azithromycin Versus Standard Care in Ambulatory COVID-19 The ATOMIC2 Trial
Johnston C, SSRN, 2021 Hydroxychloroquine with or Without Azithromycin for Treatment of Early SARS-CoV-2 Infection Among High-Risk Outpatient Adults: A Randomized Clinical Trial
Kharat A, SSRN, 2020 Self-Proning in COVID-19 Patients on Low-Flow Oxygen Therapy: A Cluster Randomised Controlled Trial
Lattman E, medRxiv, 2021 Randomized, Comparative, Clinical Trial to Evaluate Efficacy and Safety of PNB001 in Moderate COVID-19 Patients
Lin YR, J Aerosol Med Pulm Drug Deliv, 2021 Mycobacterium vaccae Nebulization in the Treatment of COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial.
Moni M, medRxiv, 2021 A Feasibility Trial to Evaluate the Composite Efficacy of Inhaled Nitric Oxide in the Treatment of Covid 19 Pneumonia : Impact on Viral Load and Clinical Outcomes
Puskarich M, SSRN, 2021 Effect of Losartan on Symptomatic Outpatients with COVID-19: A Randomized Clinical Trial
Rutgers A, SSRN, 2021  Timely Administration of Tocilizumab Improves Survival of Hospitalized COVID-19 Patients   
Samimagham H, Research Square, 2021 The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: AÂ phase III randomised clinical trial
Seet RCS, Int J Infect Dis, 2021 Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial

2 new vaccine RCTs:

Li J, Nat Med, 2021 Safety and immunogenicity of the SARS-CoV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, double-blind phase 1 study.
Pan HX, medRxiv, 2021 Immunogenicity and Safety of a SARS-CoV-2 Inactivated Vaccine (KCONVAC) in Healthy Adults: Two Randomized, Double-blind, and Placebo-controlled Phase 1/2 Clinical Trials

RCTs of long covid and psychological disorder identified not extracted

In addition to 12 RCT evaluating Non-pharmacological interventions and long COVID treatments included and pending extraction:

Abdelalim A, Am J Otolaryngol, 2021 Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial
Abdelmaksoud AA, Biol Trace Elem Res, 2021 Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc
Al-Alawi M, JMIR Mental Health, 2021 Efficacy of a six-week-long therapist-guided online therapy versus self-help internet-based therapy for COVID-19 induced anxiety and depression: Open-label, pragmatic, randomized controlled trial
Kong X, Front Psychiatry, 2020 Effect of Psychological-Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients
Li J, Front Psychiatry, 2020 The Effect of Cognitive Behavioral Therapy on Depression, Anxiety, and Stress in Patients With COVID-19: A Randomized Controlled Trial.
Nambi G, ResearchSquare, 2020 Low or Moderate Intensity Aerobic Training: Its Role in Clinical and Psychological Aspects of Community Dwelling COVID-19 Asymptomatic Older Adults With Sarcopenia Symptoms
Rashid RA, Am J Otolaryngol, 2021 Effect of nasal corticosteroid in the treatment of anosmia due to COVID-19: A randomised double-blind placebo-controlled study.
Shaygan M, ResearchSquare, 2020 The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial
Sotoudeh H.G, Iran J Psychiatry, 2020 The Effect of Brief Crisis Intervention Package on Improving Quality of Life and Mental Health in Patients with COVID-19.
Vaira LA, Rhinology, 2020 Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients.
Wu X, Neuropsychiatry, 2020 Application of Psychological Support Therapy in the Treatment of Patients with COVID-19 Complicated With Emotional Disorders: A Randomized Controlled Trial
Zhao Z, Research Square, 2020 A Randomized Controlled Study of Muscle Training Exercise Based Pulmonary Rehabilitation on Activity of Daily Living in Patients with Coronavirus Disease 2019