Weekly Update

Weekly Update: June 7 to June 11, 2021

New RCTs with results available

6 new RCTs with results are available on our website: see here for vaccine et here for treatment

Elgohary M, medrxiv, 2021 Efficacy of Sofosbuvir plus Ledipasvir in Egyptian patients with COVID-19 compared to standard treatment: Randomized controlled trial
Frenck RW, N Engl J Med, 2021 Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents.
Kharat A, Thorax, 2021 Self-Proning in COVID-19 Patients on Low-Flow Oxygen Therapy: A Cluster Randomised Controlled Trial
Lawler PR, medrxiv, 2021 Therapeutic Anticoagulation in Non-Critically Ill Patients with Covid-20
Sivapalasingam S, medrxiv, 2021 A Randomized Placebo-Controlled Trial of Sarilumab in Hospitalized Patients with Covid-20
Zarehoseinzade E, Med J Islam Repub Iran, 2021 Finasteride in hospitalized adult males with Covid-19: A risk factor for severity of the disease or an adjunct treatment: A randomized controlled clinical trial

RCTs pending data extraction

14 new pharmacological and/or preventive RCTs:

Abd-Elsalam S, J Med Virol, 2021 Clinical Study Evaluating the Efficacy of Ivermectin in COVID-19 Treatment: A Randomized Controlled Study.
Bieber A, medrxiv, 2021 Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19, A double-blind, randomized placebo-controlled trial.
Byakika-Kibwika P, ResearchSquare, 2021 Safety and Efficacy of Hydroxychloroquine for Treatment of Non-Severe COVID-19 in Adults in Uganda: A Randomized Open Label Phase II Clinical Trial
Chahla R, ResearchSquare, 2021 Cluster Randomised Trials - Ivermectin Repurposing For COVID-19 Treatment Of Outpatients With Mild Disease In Primary Health Care Centers
Cohen MS, JAMA, 2021 Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial.
Dilogo IH, Stem Cells Transl Med, 2021 Umbilical cord mesenchymal stromal cells as critical COVID-19 adjuvant therapy: A randomized controlled trial.
Lopes RD,Lancet, 2021 Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial.
Samaha AA, Viruses, 2021 Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon.
Sayad B, J Antimicrob Chemother, 2021 Efficacy and safety of sofosbuvir/velpatasvir versus the standard of care in adults hospitalized with COVID-19: a single-centre, randomized controlled trial.
Singh B, medrxiv, 2021 Safety and efficacy of antiviral therapy alone or in combination in COVID-19 - a randomized controlled trial (SEV COVID Trial)
Sivapalan P, Eur Respir J, 2021 Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19-a randomised double-blinded placebo-controlled trial.
Tian F, Eur J Phys Rehabil Med, 2021 Efficacy and safety of short-wave diathermy treatment for moderate COVID-19 patients: a prospective, double-blind, randomized controlled clinical study.
Weinreich D, medrxiv, 2021 REGEN-COV Antibody Cocktail Clinical Outcomes Study in Covid-19 Outpatients
Winchester S, J Infect, 2021 Clinical Efficacy of Nitric Oxide Nasal Spray (NONS) for the Treatment of Mild COVID-19 Infection.

2 new vaccine RCTs:

Borobia A M, SSRN, 2021 Reactogenicity and Immunogenicity of BNT162b2 in Subjects Having Received a First Dose of ChAdOx1s: Initial Results of a Randomised, Adaptive, Phase 2 Trial (CombiVacS)
Madhi S,ResearchSquare,2021 ChAdOx1 nCoV-19 (AZD1222) Vaccine in People Living With and Without HIV

RCTs identified not extracted

In addition to 13 RCT evaluating disorder and long COVID treatments included and pending extraction:

Abdelalim A, Am J Otolaryngol, 2021 Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial
Abdelmaksoud AA, Biol Trace Elem Res, 2021 Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc
Al-Alawi M, JMIR Mental Health, 2021 Efficacy of a six-week-long therapist-guided online therapy versus self-help internet-based therapy for COVID-19 induced anxiety and depression: Open-label, pragmatic, randomized controlled trial
Kong X, Front Psychiatry, 2020 Effect of Psychological-Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients
Li J, Front Psychiatry, 2020 The Effect of Cognitive Behavioral Therapy on Depression, Anxiety, and Stress in Patients With COVID-19: A Randomized Controlled Trial.
Liu Y, Psychol Health Med, 2021 Effects of group psychological intervention combined with pulmonary rehabilitation exercises on anxiety and sleep disorders in patients with mild coronavirus disease 2019 (COVID-19) infections in a Fangcang hospital.
Nambi G, ResearchSquare, 2020 Low or Moderate Intensity Aerobic Training: Its Role in Clinical and Psychological Aspects of Community Dwelling COVID-19 Asymptomatic Older Adults With Sarcopenia Symptoms
Rashid RA, Am J Otolaryngol, 2021 Effect of nasal corticosteroid in the treatment of anosmia due to COVID-19: A randomised double-blind placebo-controlled study.
Shaygan M, ResearchSquare, 2020 The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial
Sotoudeh H.G, Iran J Psychiatry, 2020 The Effect of Brief Crisis Intervention Package on Improving Quality of Life and Mental Health in Patients with COVID-19.
Vaira LA, Rhinology, 2020 Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients.
Wu X, Neuropsychiatry, 2020 Application of Psychological Support Therapy in the Treatment of Patients with COVID-19 Complicated With Emotional Disorders: A Randomized Controlled Trial
Zhao Z, Research Square, 2020 A Randomized Controlled Study of Muscle Training Exercise Based Pulmonary Rehabilitation on Activity of Daily Living in Patients with Coronavirus Disease 2019

In addition to 4 RCT evaluating other non-pharmacological interventions:

Gutierrez-Castrellon P, medrxiv, 2021 Efficacy and safety of novel probiotic formulation in adult Covid19 outpatients: a randomized, placebo-controlled clinical trial
Hamidi-Alamdari D, Rev Invest Clin, 2021 METHYLENE BLUE FOR TREATMENT OF HOSPITALIZED COVID-19 PATIENTS: A RANDOMIZED, CONTROLLED, OPEN-LABEL CLINICAL TRIAL, PHASE 2.
Sehgal I, ERJ Open Res, 2021 A randomised trial of Mycobacterium w in critically ill patients with COVID-19 (ARMY-1)
Supady A, Lancet Respir Med, 2021 May Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial.

In addition to 1 RCT evaluating other non COVID-19 vaccines:

Tsilika M, medrxiv, 2021 ACTIVATE-2: A DOUBLE-BLIND RANDOMIZED TRIAL OF BCG VACCINATION AGAINST COVID19 IN INDIVIDUALS AT RISK