Weekly Update

Weekly Update: January 18 to January 22, 2021

We identify and now report 7 new studies with results available on our website :

Babalola O E, medRxiv, 2021 Ivermectin shows clinical benefits in mild to moderate Covid19 disease: A randomised controlled double blind dose response study in Lagos.
De Marchi T, medRxiv, 2020 Effects of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) in patients with severe COVID-19 requiring intubation: a pragmatic randomized placebo-controlled trial
Feld J, medRxiv, 2020 Peginterferon-lambda for the treatment of COVID-19 in outpatients
Ghandehari S, SSRN, 2020 Progesterone in Addition to Standard of Care Versus Standard of Care Alone in the Treatment of Men Admitted to the Hospital with Moderate to Severe COVID-19: A Randomised Control Phase 1 Trial
Khan Chachar AZ, Int J Sci, 2020 Effectiveness of Ivermectin in SARS-CoV-2/COVID-19 Patients
Lanzoni G, Stem Cells Transl Med , 2020 Umbilical Cord Mesenchymal Stem Cells for COVID-19 ARDS: A Double Blind, Phase 1/2a, Randomized Controlled Trial
Maldonado V, Int Immunopharmacol, 2020 Pentoxifylline decreases serum LDH levels and increases lymphocyte count in COVID-19 patients: Results from an external pilot study

We have also included and presently extracting 20 new pharmacological and/or preventive RCTs:

ADER F, medRxiv, 2021 (DisCoVeRy trial) Antiviral drugs in hospitalized patients with COVID-19 - the DisCoVeRy trial
Bundgaard H, Ann Intern Med. 2020 Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers
Cadegiani F, medRxiv, 2020 5-Alpha-Reductase Inhibitors Reduce Remission Time of COVID-19: Results From a Randomized Double Blind Placebo Controlled Interventional Trial in 130 SARS-CoV-2 Positive Men.
Cadegiani F, ResearchSquare, 2021 Proxalutamide (GT0918) Reduces the Rate of Hospitalization and Death in COVID-19 Male Patients: A Randomized Double-Blinded Placebo-Controlled Trial.
Cadegiani FA, Research Square, 2020 Dutasteride Reduces Viral Shedding, Inflammatory Responses and Time-to-Remission in COVID-19: Biochemical Findings of a Randomized Double-Blind Placebo Controlled Interventional Trial (DUTA AndroCoV-Trial - Biochemical).
Cohen J, Lancet Respir Med, 2021 Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial
Darazam I, ResearchSquare, 2021 Role of Interferon Therapy in Severe COVID-19: The COVIFERON Randomized Controlled Trial
Darazam I, ResearchSquare, 2021 An Investigation Into the Beneficial Effects of High-Dose Interferon beta 1-a, Compared to Low-Dose Interferon Beta 1-a (the base therapeutic regimen) in moderate to severe COVID-19
Elgazzar A, ResearchSquare, 2020 Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic
Ghahremani M, ResearchSquare, 2021 Exogenous Surfactant Versus Placebo in the Treatment of Moderate and Severe ARDS in COVID-19: The Pilot Study of a Clinical Trial
Hashim A, medRxiv, 2020 Controlled randomized clinical trial on using Ivermectin with Doxycycline for treating COVID-19 patients in Baghdad, Iraq
Holubovska O, medRxiv, 2021 Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial
JamaliMoghadamSiahkali S, ResearchSquare, 2021 Safety and Effectiveness of High-Dose Vitamin C in Patients with COVID-19
Kirti R, medRxiv, 2021 Ivermectin as a potential treatment for mild to moderate COVID-19: A double blind randomized placebo-controlled trial
Kumari P, Cureus, 2020 The Role of Vitamin C as Adjuvant Therapy in COVID-19.
Niaee MS, Research Square, 2020, Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial.
Roostaei A, ResearchSquare, 2021 Efficacy and Safety of Levamisole Treatment in Clinical Presentations of Patients With COVID-19: A Double-Blind, Randomized, Controlled Trial
Sedighiyan M, Authorea, 2021 ( preprint Omega-3 polyunsaturated fatty acids supplementation improve clinical symptoms in patients with covid-19: A randomized clinical trial
Shah M, Int Immunopharmacol, 2021 Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study).
Torres-Zambrano GM, medRxiv, 2020 Renal Involvement in patients with COVID-19 Pneumonia and Outcomes after Stem Cell Nebulization

We have also included and presently extracting 4 new vaccine RCTs:

Ella R, medRxiv, 2020 Safety and immunogenicity clinical trial of an inactivated SARS-CoV-2 vaccine, BBV152 (a phase 2, double-blind, randomised controlled trial) and the persistence of immune responses from a phase 1 follow-up report
Shilong Y, medRxiv, 2020 Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD protein vaccine against COVID-19 in adults: pooled analysis of two randomized, double-blind, placebo-controlled, phase 1 and 2 trials
Ward BJ, medRxiv, 2020 Phase 1 trial of a Candidate Recombinant Virus-Like Particle Vaccine for Covid-19 Disease Produced in Plants
Zhu F, ResearchSquare, 2021 First report demonstrating the safety and immunogenicity of the SARS-COV-2 BNT162b1 mRNA vaccine in younger and older Chinese adults: a randomized, placebo-controlled, observer-blind Phase I study

In addition to 11 RCT evaluating Non-pharmacological interventions and long COVID treatments included and pending extraction:

Abdelalim A, Am J Otolaryngol, 2021 Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial
Abdelmaksoud AA, Biol Trace Elem Res, 2021 Olfactory Disturbances as Presenting Manifestation Among Egyptian Patients with COVID-19: Possible Role of Zinc
Kharat A, SSRN, 2020 Self-Proning in COVID-19 Patients on Low-Flow Oxygen Therapy: A Cluster Randomised Controlled Trial
Kong X, Front Psychiatry, 2020 Effect of Psychological–Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients
Li J, Front Psychiatry, 2020 The Effect of Cognitive Behavioral Therapy on Depression, Anxiety, and Stress in Patients With COVID-19: A Randomized Controlled Trial.
Nambi G, ResearchSquare, 2020 Low or Moderate Intensity Aerobic Training: Its Role in Clinical and Psychological Aspects of Community Dwelling COVID-19 Asymptomatic Older Adults With Sarcopenia Symptoms
Shaygan M, ResearchSquare, 2020 The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial
Sotoudeh H.G, Iran J Psychiatry, 2020 The Effect of Brief Crisis Intervention Package on Improving Quality of Life and Mental Health in Patients with COVID-19.
Vaira LA, Rhinology, 2020 Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients.
Wu X, Neuropsychiatry, 2020 Application of Psychological Support Therapy in the Treatment of Patients with COVID-19 Complicated With Emotional Disorders: A Randomized Controlled Trial
Zhao Z, Research Square, 2020 A Randomized Controlled Study of Muscle Training Exercise Based Pulmonary Rehabilitation on Activity of Daily Living in Patients with Coronavirus Disease 2019