Weekly Update

Weekly Update: September 20 to September 24, 2021

New Studies with results available

20 new RCTs with results are available on our website: see here for vaccine et here for treatment

Ananworanich J, Clin Infect Dis, 2021 Randomized study of rivaroxaban vs. placebo on disease progression and symptoms resolution in high-risk adults with mild COVID-19.
ARCHITECTS, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
Bhushan S, Int J Infect Dis, 2021 Efficacy and Safety of Pegylated Interferon-α2b in Moderate COVID-19: A phase 3, randomized, comparator-controlled, open-label study.
CORIMUNO-TOCI-2 (ICU), Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
COV-AID, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
COVIDOSE-2, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
COVIDSTORM, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
COVITOZ-01, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
Ehrmann S, Lancet Respir Med, 2021 Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial
HMO-0224-20, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
IMMCOVA, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
Kosmopoulos A, iScience, 2021 A Randomized Trial of Icosapent Ethyl in Ambulatory Patients with COVID-19
McCreary E, medrxiv, 2021 A Learning Health System Randomized Trial of Monoclonal Antibodies for Covid-19
Moreira TG, Front Immunol, 2021 Nasal Administration of Anti-CD3 Monoclonal Antibody (Foralumab) Reduces Lung Inflammation and Blood Inflammatory Biomarkers in Mild to Moderate COVID-19 Patients: A Pilot Study.
Rangon CM, Front Physiol, 2021 Auricular Neuromodulation for Mass Vagus Nerve Stimulation: Insights From SOS COVID-19 a Multicentric, Randomized, Controlled, Double-Blind French Pilot Study.
Reis G, medRxiv, 2021 EFFECT OF EARLY TREATMENT WITH FLUVOXAMINE ON RISK OF EMERGENCY CARE AND HOSPITALIZATION AMONG PATIENTS WITH COVID-19: THE TOGETHER RANDOMIZED PLATFORM CLINICAL TRIAL
REMDACTA, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis
Rodrigues C, Int J Antimicrob Agents, 2021 Hydroxychloroquine plus azithromycin early treatment of mild COVID-19 in outpatient setting: a randomized, double-blinded, placebo-controlled clinical trial evaluating viral clearance.
Shinkai M, Infect Dis Ther, 2021 Efficacy and Safety of Favipiravir in Moderate COVID-19 Pneumonia Patients without Oxygen Therapy: A Randomized, Phase III Clinical Trial.
TOCOVID, Unpublished, 2021 Results from Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 A Meta-analysis

17 new vaccine observational studies with results are available on our website: see here

Bajema K, MMWR, 2021 Effectiveness of COVID-19 mRNA Vaccines Against COVID-19?Associated Hospitalization ? Five Veterans Affairs Medical Centers, United States, February 1?August 6, 2021
Bar-On Y, N Engl J Med, 2021 " Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel
Barlow R, medRxiv, 2021 Effectiveness of COVID-19 Vaccines Against SARS-CoV-2 Infection During a Delta Variant Epidemic Surge in Multnomah County, Oregon, July 2021
Bruxvoort K, SSRN, 2021 Real-World Effectiveness of the mRNA-1273 Vaccine Against COVID-19: Interim Results from a Prospective Observational Cohort Study
Chemaitelly H, medRxiv, 2021 SARS-CoV-2 vaccine effectiveness in immunosuppressed kidney transplant recipients
Elliott P, medRxiv, 2021 REACT-1 round 13 final report: exponential growth, high prevalence of SARS-CoV-2 and vaccine effectiveness associated with Delta variant in England during May to July 2021
Fowlkes A, MMWR, 2021 Effectiveness of COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Frontline Workers Before and During B.1.617.2 (Delta) Variant Predominance - Eight U.S. Locations, December 2020-August 2021
Goldberg Y, medRxiv, 2021 Waning immunity of the BNT162b2 vaccine:A nationwide study from Israel
Grannis S, MMWR, 2021 Interim Estimates of COVID-19 Vaccine Effectiveness Against COVID-19?Associated Emergency Department or Urgent Care Clinic Encounters and Hospitalizations Among Adults During SARS-CoV-2 B.1.617.2 (Delta) Variant Predominance ? Nine States,
Griffin J, MMWR, 2021 SARS-CoV-2 Infections and Hospitalizations Among Persons Aged ?16 Years, by Vaccination Status ? Los Angeles County, California, May 1?July 25, 2021
Hitchings M, medRxiv, 2021 Effectiveness of CoronaVac in the setting of high SARS-CoV-2 P.1 variant transmission in Brazil: A test-negative case-control study
Lefèvre B, medRxiv, 2021 Impact of B.1.351 (beta) SARS-CoV-2 variant on BNT162b2 mRNA vaccine effectiveness in long-term care facilities of eastern France: a retrospective cohort study
Li X-N, Emerg Microbes Infect, 2021 . Efficacy of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou: A test-negative case-control real-world study
Patalon T, medRxiv, 2021 Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel
Rosenberg E, MMWR, 2021 New COVID-19 Cases and Hospitalizations Among Adults, by Vaccination Status ? New York, May 3?July 25, 2021\
Stowe J, PHE Publishing, 2021 Effectiveness of COVID-19 vaccines against hospital admission with the Delta (B.1.617.2) variant
Thompson M, N Engl J Med, 2021 Effectiveness of Covid-19 Vaccines in Ambulatory and Inpatient Care Settings

Studies pending data extraction

10 new pharmacological and/or preventive RCTs:

Puskarich M, medrxiv, 2021 Effect of losartan on hospitalized patients with COVID-19-induced lung injury: A randomized clinical trial
Baklaushev VP, Journal of Clinical Practice, 2021 Safety and efficacy of convalescent plasma for COVID-19: the preliminary results of a clinical trial COVID-19
Buonfrate D, SSRN, 2021 High Dose Ivermectin for the Early Treatment of COVID-19 (COVIER Study): A Randomised, Double-Blind, Multicentre, Phase II, Dose-Finding, Proof of Concept Clinical Trial
Choudhary M, medrxiv, 2021 Emergence of SARS-CoV-2 Resistance with Monoclonal Antibody Therapy
Clemency B, medrxiv, 2021 A randomized controlled trial of inhaled ciclesonide for outpatient treatment of symptomatic COVID-19 infections
Elamir YM, Bone, 2021 A Randomized Pilot Study Using Calcitriol in Hospitalized Patients.
Ghanei M, Respir Res, 2021 The efficacy of corticosteroids therapy in patients with moderate to severe SARS-CoV-2 infection: a multicenter, randomized, open-label trial.
Klussmann J, ResearchSquare, 2021 COVID-19: Azelastine nasal spray Reduces Virus-load In Nasal swabs (CARVIN). Early intervention with azelastine nasal sprays reduces viral load in SARS-CoV-2 infected patients. First report on a double-blind placebo-controlled phase II clin
Naggie S, medRxiv, 2021 Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial (HERO-HCQ)
Pascual-Figal DA, Int J Gen Med, 2021 Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID).

2 new vaccine RCTs:

Hsieha SM, EClinicalMedicine, 2021 Safety and immunogenicity of a Recombinant Stabilized Prefusion SARS-CoV-2 Spike Protein Vaccine (MVCCOV1901) Adjuvanted with CpG 1018 and Aluminum Hydroxide in healthy adults: A Phase 1, dose-escalation study
Wu S, Lancet Infect Dis, 2021 Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial

We have identified additional COVID-19 RCTs assessing:

  1. long COVID
  2. other interventions (dietary supplements or minerals and other technologies (e.g. cytokine adsorption)
  3. other COVID vaccines.

These interventions were not prioritized but they might be included in the future. Details here