Pharmacologic treatments for covid-19 patients

Vitamin C vs Standard of care/Placebo


Outpatients

Forest plots
(last update: 2021-05-27)

Hospitalized patients

Forest plots
(last update: 2021-05-27)

Summary of findings
(last update: 2021-06-01)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=63

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04342728
COVID A to Z
Thomas S, JAMA Netw Open (2021)
Full text
Commentary
Commentary
Not reported/unclear

Vitamin C

Zinc

Vitamin C+Zinc

Vitamin C

Vitamin C

Zinc

Standard care

Standard care

Standard care

Vitamin C+Zinc

Zinc

Vitamin C+Zinc

RCT Outpatients with confirmed COVID-19 (asymptomatic-mild) treated by multiple centers in the US. N=214
Some concerns
Details

Full description

IRCT20200411047025N1
JamaliMoghadamSiahkali S, Eur J Med Res (2021)
Full text
Commentary
Public/non profit

Vitamin C

Standard care

RCT Patients with suspected or confirmed COVID-19 (severe) admitted to a single center in Iran N=60 N/A

Full description

N/A
Kumari P, Cureus (2020)
Full text
Commentary
Commentary
Not reported/unclear

Vitamin C

Standard care

RCT Patients with COVID-19 (severe) admitted to a single center in Pakistan N=150 N/A

Full description

NCT04264533
Zhang J, Ann. Intensive Care (2021)
Full text
Commentary
Public/non profit

Vitamin C

Placebo

RCT Patients with confirmed COVID-19 (severe-critical) admitted to 3 centers in China N=56
Some concerns
Details

Full description