Trial *
Publication Kumari P, Cureus (2020) (published paper)
Dates: 2020-03-01 to 2020-07-30
Funding: No specific funding (no funding "All authors have declared that no financial support was received from any organization for the submitted work.")
Conflict of interest: No

Methods
RCT
Blinding: Unblinded
Location : Single center / Pakistan
Follow-up duration (days): *
Inclusion criteria
  • Patients who were admitted with severe COVID-19 infection diagnosed based on the national health guidelines of Pakistan

    Guidelines:
    In adults, clinical signs of pneumonia (fever/ cough) plus, any of the following:
    Respiratory rate > 30
    Severe respiratory distress
    SpO2 ≤ 90% on room air
    Chest X-ray involving >50% of lung fields
Exclusion criteria
  • Patients who needed mechanical ventilation within 12 hours of admission
Interventions
Treatment
Vitamin C
50 mg/kg/day IV.
Control
Standard care

Participants
Randomized
participants :
Vitamin C=75
Standard care=75
Characteristics of participants
N= 150
Mean age : NR
0 males
Severity : Mild: n=0 / Moderate: n=0 / Severe: n=150 Critical: n=0
Number of vaccinated participants: NR
Primary outcome
In the register
NR
In the report
NR
Documents
available

Protocol

NR

Statistical plan

NR

Data-sharing willing stated in the publication:

Not reported
Risk of bias
Overall
The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review
*
General comment This study is pending contact with authors due to lack of information on outcome timepoints, and overall follow-up.

The published article was used in data extraction and risk of bias assessment. Trial registry, protocol, and statistical analysis plan were not available at the time of data extraction. The study reported on need for mechanical ventilation (12/75 vs. 15/75) and on overall mortality (7/75 vs. 11/75), however, these data have not been added to analyses because follow-up time-points were not reported.