Pharmacologic treatments for covid-19 patients

Molnupiravir vs Standard care/Placebo


Outpatients

Forest plots
(last update: 2022-04-15)

Summary of findings
(last update: 2022-04-27)

Hospitalized patients

Forest plots
(last update: 2022-03-04)

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
CTRI/2021/07/034588
Koudinya Tippabhotla S, SSRN, 2022
Full text
Commentary
Commentary
Private

Molnupiravir

Standard care

RCT Outpatients with confirmed COVID-19 (mild) treated at 16 centers in India N=1220
Some concerns
Details

Full description

NCT04575584
MOVe-IN
Arribas J, N Engl J Med Evidence , 2021
Full text
Commentary
Commentary
Private

Molnupiravir 200mg

Placebo

RCT Patients with suspeccted or confirmed COVID-19 (mild-moderate-severe) admitted to 65 centers in Brazil, Chile, Colombia, France, Israel, Mexico, Philippines, Poland, Russia, South Africa, South Korea N=304
Some concerns
Details

Full description

NCT04575597
MOVe-OUT
Caraco Y, N Engl J Med Evidence, 2021
Full text
Commentary
Private

Molnupiravir 200

Molnupiravir 400

Molnupiravir

Placebo

RCT Outpatients with confirmed COVID-19 (asymptomatic, mild) treated by 82 centers in 14 countries N=302
Low
Details

Full description

NCT04575597
Jayk Bernal A, N Engl J Med, 2021
Full text
Commentary
Private

Molnupiravir

Placebo

RCT Outpatients with confirmed COVID-19 (mild-moderate) treated by 107 sites in 20 countries. N=1433
Low
Details

Full description

NCT04405570
Fischer W, Sci Transl Med, 2021
Full text
Full text
Commentary
Commentary
Commentary
Mixed

Molnupiravir 200

Molnupiravir 400

Molnupiravir

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated by 10 centers in the USA N=202
High
Details

Full description