Pharmacologic treatments for covid-19 patients

Ivermectin vs Standard care/Placebo

This comparison will not be updated. Last search date 28 Feb, 2022.

Study Samaha A, Viruses 2021 has been retracted on October 26, 2021. The study was excluded from the analysis and grade assessment by December 17 the latest.

Study Pott-Junior H, 2021 (Toxicology Reports) retracted on May 11, 2022.

Outpatients

Forest plots
(last update: 2022-06-02)

Summary of findings
(last update: 2022-06-03)

Hospitalized patients

Forest plots
(last update: 2022-06-02)

Summary of findings
(last update: 2022-06-03)

To access all information :

You can print it as a pdf. You can also click on each forest plot with your right mouse button and download.

Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=36

Back to your research

Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
N/A
Manomaipiboon A, Research square, 2022
Full text
Commentary
Commentary
Public/non profit

Ivermectin

Placebo

RCT Patients with confirmed COVID-19 (mild-moderate) admitted to a single center in Thailand. N=74
Some concerns
Details

Full description

NCT04920942
I-TECH
Lim SCL, JAMA Intern Med, 2022
Full text
Commentary
Commentary
Not reported/unclear

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (mild) admitted to 21 centers in Malaysia. N=500
Some concerns
Details

Full description

NCT04529525
IVERCOR-COVID19
Vallejos J, BMC Infect Dis, 2021
Full text
Commentary
No specific funding

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (asymptomatic-mild) treated by a single center in Argentina N=501
Low
Details

Full description

NCT04716569
Aref ZF, Int J Nanomed, 2021
Full text
Commentary
Public/non profit

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (mild, symptomatic) treated at a single center in Egypt. N=114
Some concerns
Details

Full description

NCT04429711
Biber A, medRxiv, 2021
Full text
Commentary
Commentary
No specific funding

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated by multiple centers in Israel N=116
Some concerns
Details

Full description

NCT04784481
Chahla R, Research Square, 2021
Full text
Commentary
Public/non profit

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (mild) treated by multiple centers in Argentina. N=254
Some concerns
Details

Full description

NCT04403555
Abd-Elsalam S, J Med Virol, 2021
Full text
Commentary
Not reported/unclear

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 admitted to 2 centers in Egypt N=164
Some concerns
Details

Full description

IRCT20111224008507N3
Shahbaznejad L, Clin Ther, 2021
Full text
Commentary
No specific funding

Ivermectin

Standard care

RCT Patients with suspected or confirmed COVID-19 (moderate-critical) admitted to 2 centers in Iran. N=73
Some concerns
Details

Full description

N/A
Kishoria N, PIJR, 2020
Full text
Commentary
Not reported/unclear

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (mild/asymptomatic) admitted to a single center in India. N=32
Some concerns
Details

Full description

NCT04391127
Beltran-Gonzalez J, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit

Hydroxychloroquine

Ivermectin

Hydroxychloroquine

Placebo

Placebo

Ivermectin

RCT Patients with suspected or confirmed COVID-19 (moderate/severe) admitted to a single center in Mexico N=106
Some concerns
Details

Full description

NCT04405843
Lopez-Medina E, JAMA, 2021
Full text
Commentary
Commentary
Mixed

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated by a single center in Colombia N=476
Some concerns
Details

Full description

NCT04392713
Shah Bukhari K H, medRxiv, 2021
Full text
Commentary
Commentary
Not reported/unclear

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (mild) admitted to a single center in Pakistan N=100
High
Details

Full description

CTRI/2020/06/026001
RIVET-COV
Mohan A, J Infect Chemother, 2021
Full text
Full text
Commentary
Mixed

Ivermectin 12 mg

Ivermectin 24 mg

Ivermectin 12 mg

Placebo

Placebo

Ivermectin 24 mg

RCT Patients with confirmed COVID-19 (asymptomatic-mild-moderate) admitted to a single center in India N=157
Some concerns
Details

Full description

IRCT20200408046987N1
Niaee MS, Asian Pac J Trop Med, 2021
Full text
Commentary
Commentary
Mixed

Ivermectin Once-off

Ivermectin Once-off

Ivermectin 3-day LD

Ivermectin 3-day LD

Ivermectin 1-day BDS

Ivermectin 1-day BDS

Ivermectin 3-day HD

Ivermectin 3-day HD

Placebo

Standard care

Placebo

Standard care

Placebo

Standard care

Placebo

Standard care

RCT Patients with CT or PCR confirmed COVID-19 (unclear severity) admitted to 5 centers in Iran. N=180
Some concerns
Details

Full description

NCT04739410
Khan Chachar AZ, Int J Sci, 2020
Full text
Commentary
No specific funding

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (symptomatic-mild) treated at a single center in Pakistan N=50
High
Details

Full description

CTRI/2020/08/027225
Ravikirti R, J Pharm Pharm Sci, 2021
Full text
Full text
Commentary
Commentary
Commentary
Mixed

Ivermectin

Placebo

RCT Patients with COVID-19 (mild-severe) admitted to a single center in India N=115
High
Details

Full description

NCT04390022
SAINT
Chaccour C, EClinicalMedicine, 2021
Full text
Commentary
Mixed

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (mild) attending the emergency room at a single center in Spain N=24
Some concerns
Details

Full description

NCT04407130
Ahmed S, Int J Infect Dis, 2020
Full text
32506-6/fulltext Commentary
Private

Ivermectin+Doxycycline

Ivermectin

Ivermectin

Placebo

RCT Patients with confirmed COVID-19 (mild) admitted to hospital in Bangladesh. N=72
Some concerns
Details

Full description

NCT04381884
Krolewiecki A, EClinicalMedicine, 2021
Full text
Full text
Commentary
Commentary
Mixed

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 4 centers in Argentina N=45
Some concerns
Details

Full description

N/A
Podder C, IMC J Med Sci, 2020
Full text
No specific funding

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (mild-moderate) treated at a single center in Bangladesh N=62
High
Details

Full description

NCT04438850
COVER
Buonfrate D, Int J Antimicrob Agents, 2022
Full text
Full text
Commentary
Commentary
Commentary
Public/non profit

Ivermectin 600

Ivermectin 600

RCT Outpatients with confirmed COVID 19 (asymptomatic/mild) treated by 4 centers in Italy. N=93
Some concerns
Details

Full description

NCT04646109
Okumus N, BMC Infectious Disea, 2021
Full text
Commentary
Commentary
Public/non profit

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (severe) admitted to four centers in Turkey N=66
High
Details

Full description