Pharmacologic treatments for covid-19 patients

Ivermectin vs Standard care/Placebo


Outpatients

Forest plots
(last update: 2021-08-26)

Summary of findings
(last update: 2021-08-30)

Hospitalized patients

Forest plots
(last update: 2021-09-24)

Summary of findings
(last update: 2021-10-08)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=36

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04529525
IVERCOR-COVID19
Vallejos J, BMC Infect Dis (2021)
Full text
Commentary
No specific funding

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (asymptomatic-mild) treated by a single center in Argentina N=501
Low
Details

Full description

NCT04716569
Aref ZF, Int J Nanomed (2021)
Full text
Commentary
Public/non profit

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (mild, symptomatic) treated at a single center in Egypt. N=114
Some concerns
Details

Full description

ChiCTR2000033627
Samaha A,, Viruses (2021)
Full text
Commentary
No specific funding

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (asymptomatic-mild) recruited through testing centers in Lebanon. N=100
Some concerns
Details

Full description

NCT04784481
Chahla R, Research Square (2021)
Full text
Commentary
Public/non profit

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (mild) treated by multiple centers in Argentina. N=254
Some concerns
Details

Full description

NCT04429711
Biber A, medRxiv (2021)
Full text
Commentary
Commentary
No specific funding

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated by multiple centers in Israel N=116

Details

Full description

NCT04403555
Abd-Elsalam S, J Med Virol (2021)
Full text
Commentary
Not reported/unclear

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 admitted to 2 centers in Egypt N=164
Some concerns
Details

Full description

IRCT20111224008507N3
Shahbaznejad L, Clin Ther (2021)
Full text
Commentary
No specific funding

Ivermectin

Standard care

RCT Patients with suspected or confirmed COVID-19 (moderate-critical) admitted to 2 centers in Iran. N=73
Some concerns
Details

Full description

N/A
Kishoria N, PIJR (2020)
Full text
Commentary
Not reported/unclear

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (mild/asymptomatic) admitted to a single center in India. N=32
Some concerns
Details

Full description

NCT04391127
Beltran-Gonzalez J, medRxiv (2021)
Full text
Commentary
Commentary
Public/non profit

Hydroxychloroquine

Ivermectin

Hydroxychloroquine

Placebo

Placebo

Ivermectin

RCT Patients with suspected or confirmed COVID-19 (moderate/severe) admitted to a single center in Mexico N=106
Some concerns
Details

Full description

NCT04405843
Lopez-Medina E, JAMA (2021)
Full text
Commentary
Commentary
Mixed

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated by a single center in Colombia N=476
Some concerns
Details

Full description

NCT04392713
Shah Bukhari K H, medRxiv (2021)
Full text
Commentary
Commentary
Not reported/unclear

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (mild) admitted to a single center in Pakistan N=100
High
Details

Full description

CTRI/2020/06/026001
RIVET-COV
Mohan A, J Infect Chemother (2021)
Full text
Full text
Commentary
Mixed

Ivermectin 12 mg

Ivermectin 24 mg

Ivermectin 12 mg

Placebo

Placebo

Ivermectin 24 mg

RCT Patients with confirmed COVID-19 (asymptomatic-mild-moderate) admitted to a single center in India N=157
Some concerns
Details

Full description

IRCT20200408046987N1
Niaee MS, Asian Pac J Trop Med (2021)
Full text
Commentary
Commentary
Mixed

Ivermectin Once-off

Ivermectin Once-off

Ivermectin 3-day LD

Ivermectin 3-day LD

Ivermectin 1-day BDS

Ivermectin 1-day BDS

Ivermectin 3-day HD

Ivermectin 3-day HD

Placebo

Standard care

Placebo

Standard care

Placebo

Standard care

Placebo

Standard care

RCT Patients with CT or PCR confirmed COVID-19 (unclear severity) admitted to 5 centers in Iran. N=180
Some concerns
Details

Full description

NCT04739410
Khan Chachar AZ, Int J Sci (2020)
Full text
Commentary
No specific funding

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (symptomatic-mild) treated at a single center in Pakistan N=50
High
Details

Full description

CTRI/2020/08/027225
Ravikirti R, J Pharm Pharm Sci (2021)
Full text
Full text
Commentary
Commentary
Commentary
Mixed

Ivermectin

Placebo

RCT Patients with COVID-19 (mild-severe) admitted to a single center in India N=115
High
Details

Full description

NCT04390022
SAINT
Chaccour C, EClinicalMedicine (2021)
Full text
Commentary
Mixed

Ivermectin

Placebo

RCT Outpatients with confirmed COVID-19 (mild) attending the emergency room at a single center in Spain N=24
Some concerns
Details

Full description

NCT04407130
Ahmed S, Int J Infect Dis (2020)
Full text
32506-6/fulltext Commentary
Private

IVM+DX

Ivermectin

Ivermectin

Placebo

RCT Patients with confirmed COVID-19 (mild) admitted to hospital in Bangladesh. N=72
Some concerns
Details

Full description

NCT04381884
Krolewiecki A, EClinicalMedicine (2021)
Full text
Full text
Commentary
Commentary
Mixed

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 4 centers in Argentina N=45
Some concerns
Details

Full description

N/A
Podder C, IMC J Med Sci (2020)
Full text
No specific funding

Ivermectin

Standard care

RCT Outpatients with confirmed COVID-19 (mild-moderate) treated at a single center in Bangladesh N=0

Details

Full description

NCT04646109
Okumus N, BMC Infectious Disea (2021)
Full text
Commentary
Commentary
Public/non profit

Ivermectin

Standard care

RCT Patients with confirmed COVID-19 (severe) admitted to four centers in Turkey N=66
High
Details

Full description