Publication Niaee MS, Asian Pac J Trop Med (2021) (published paper)
Dates: 2020-06-01 to 2020-07-15
Funding: Mixed (Qazvin University of Medical Sciences and Science (publication); Chistasazan Notash Fartak Company Limited (registry))
Conflict of interest: *
Blinding: Double blinded, no restrictions
Multicenter / Iran |
Follow-up duration (days): 45
200 mcg/kg orally once off.
Ivermectin 3-day LD
200 mcg/kg orally on days 1, 3 and 5.
Ivermectin 1-day BDS
200 mcg/kg orally twice a day for 1 day.
Ivermectin 3-day HD
400 mcg/kg orally on day 1 followed by 200 mcg/kg on days 3 and 5
Ivermectin 3-day LD=30
Ivermectin 1-day BDS=30
Ivermectin 3-day HD=30
|Characteristics of participants|
Mean age : NR
Severity : Mild: n=* / Moderate: n=* / Severe: n=* Critical: n=*
Number of vaccinated participants: NR
|In the register|
Chest image (CT scan) at hospital clearance;
CBC and CRP
|In the report|
The primary endpoint of this trial was all-cause of mortality or clinical recovery. Clinical recovery was defined as normal temperature, respiratory rate, and oxygen saturation (>94%) without oxygen therapy sustained for 24 h.
Data-sharing willing stated in the publication:
|Risk of bias
The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review
|General comment||In addition to the published/pre-print article, the trial registry was used in data extraction and assessment of risk of bias. Neither study protocol nor statistical analysis plan was available. There were some differences between the registry and the published/pre-print article in terms of inclusion criteria, number of treatment arms, and outcomes (registry: chest CT scan, length of hospitalization, complete blood count, C-reactive protein; article: clinical recovery defined as normal fever, respiratory rate, and oxygen saturation >94% without oxygen therapy sustained for 24h). Mortality was not listed as an outcome in the registry. The study achieved its pre-stated sample size. The overall follow-up of the study is unclear.|