Pharmacologic treatments for covid-19 patients

Losartan vs Standard care/Placebo

This comparison will not be updated. Last search date 28 Feb, 2022.


Outpatients

Forest plots
(last update: 2021-07-02)

Hospitalized patients

Forest plots
(last update: 2022-03-17)

Summary of findings
(last update: 2022-03-30)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=300

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04328012
COVID MED
Freilich D, medRxiv, 2022
Full text
Commentary
Commentary
Public/non profit

Losartan

Placebo

RCT Patients with confirmed COVID-19 (mild-severe) admitted to a single center in USA N=13
Some concerns
Details

Full description

NCT04312009
Puskarich M, medRxiv, 2021
Full text
Commentary
Commentary
Public/non profit

Losartan

Placebo

RCT Patients with confirmed COVID-19 (mild - critical) admitted to 13 centers in the US. N=205
Some concerns
Details

Full description

NCT04340557
Geriak M, Infect Dis Ther, 2021
Full text
Commentary
Private

Losartan

Standard care

RCT Patients with confirmed COVID-19 (moderate) admitted to 3 centers in USA. N=32
High
Details

Full description

NCT04311177
Puskarich M, EClinicalMedicine, 2021
Full text
Commentary
Public/non profit

Losartan

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated at 3 centers in the USA N=117
Low
Details

Full description