COVID-19 vaccine effectiveness on variants of concern
(Randomized evidence)

If you want to see all variants, please click here

Gamma

Description of primary studies

Trial Type Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Intervention 1 Intervention 2
Gamma
ISRCTN89951424
AstraZeneca + University of Oxford
Clemens S, Research square , 2021
New

Full text
Commentary
Commentary
Non replicating viral vector

MenACWY

ChAdOx1

RCT
Phase 3
Adults that were SARS-CoV-2 seronegative and with no history of COVID-19 in six centers in Brazil. N=10416
Some concerns
Details

Full description

Alpha
Beta
Gamma
NCT04611802
Novavax
Dunkle L M, medRxiv, 2021
New

Full text
Commentary
Commentary
Protein subunit

NVX-CoV2373

Placebo

RCT
Phase 3
Healthy adults in 113 sites in the USA and 6 in Mexico N=29949
Some concerns
Details

Full description

Alpha
Beta
Gamma
Delta
NCT04516746
AstraZeneca + University of Oxford
Falsey A, N Engl J Med, 2021

Full text
Commentary
Non replicating viral vector

ChAdOx1

Placebo

RCT
Phase 3
Adults (22% over 65 years) at high risk for exposure to SARS-CoV-2 and populations at increased risk for Covid-19 complications at 88 sites in USA, Chile, and Peru N=32451
Some concerns
Details

Full description

Alpha
Gamma
NCT04652102; EudraCT 2020-003998-22
CureVac AG
Kremsner P, SSRN, 2021
HERALD

Full text
Commentary
Commentary
RNA based vaccine

CVnCoV

Placebo

RCT
Phase 2-3
Adults with no history of COVID-19 in 47 centers in Belgium, Germany, The Netherlands, Spain, Argentina, Colombia, Dominican Republic, Mexico, Panama and Peru N=39529
Some concerns
Details

Full description

Beta
Gamma
NCT04764422
The Government Pharmaceutical Organization (GPO); PATH; Dynavax
Pitisuttithum P, medRxiv, 2021

Full text
Commentary
Commentary
Inactivated virus

NDV-HXP-S 1mcg

NDV-HXP-S 1mcg + CpG1018

NDV-HXP-S 3mcg

NDV-HXP-S 3mcg + CpG1018

NDV-HXP-S 10mcg

Placebo

RCT
Phase 1
Healthy adults without immunosuppression negative for SARS-CoV-2 antibodies at a single center in Thailand N=210
Some concerns
Details

Full description