COVID-19 vaccine effectiveness
(Randomized evidence)

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Trial Type Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
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Intervention 1 Intervention 2
ChiCTR2000034825 ; NCT04523571
BioNTech RNA Pharmaceuticals
Li J, Nature Medicine, 2021

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Commentary
RNA based vaccine

BNT162b1 10 mcg D0/21

BNT162b1 30 mcg D0/21

Placebo

RCT
Phase 1
Healthy young adults between 18 and 55 years of age, and older adults between 65 and 85 that were SARS-COVID-2 infection-free at a single center in China. N= 144
Low
Details

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