Vaccines for covid-19 patients
If you want to see all comparisons, please click here
ChAdOx1 vs MenACWY
The Evidence profile and Summary of Findings table were updated on January 25th, 2021.You will find below the forest plots for this comparison with the general characteristics and risk of bias assessment for all RCTs identified.
Of note all trials may not be included in the synthesis.
| Trial | Type | Comparisons | Design | Participants | Sample size | Overall risk of bias Highest assessment |
Full description | |
|---|---|---|---|---|---|---|---|---|
| Intervention 1 | Intervention 2 | |||||||
|
NCT04444674 University of Oxford/AstraZeneca Madhi S, N Engl J Med, 2021 COV005 Updated Full text Commentary |
Non replicating viral vector |
ChAdOx1 5X10^10vp D0/D28 |
Placebo |
RCTPhase 1-2 | Healthy adult volunteers that were HIV-negative and SARS-CoV-2 infection-free in 7 centres in South Africa | N=2026 | N/A | |
|
ISRCTN89951424 University of Oxford/AstraZeneca Voysey M, Lancet, 2020 COV003 Updated Full text Commentary |
Non replicating viral vector |
ChAdOx1 SD/SD |
MenACWY/saline |
RCTPhase 3 | Healthy SARS-CoV-2 serology/DNA negative adults in six centres in Brazil | N=10002 |
Some concerns Details |
|
|
NCT04400838 University of Oxford/AstraZeneca Voysey M, Lancet, 2020 COV002 Updated Full text Commentary |
Non replicating viral vector |
ChAdOx1 LD/SD ChAdOx1 SD/SD |
MenACWY |
RCTPhase 2/3 | Healthy adults in 18 centres in the UK | N=10673 |
Some concerns Details |
|
The link in the column "Overall risk of bias" provides access to a complete description of the assessment of each risk of bias domain with supports for judgement produced using the Revised Cochrane risk-of-bias tool for randomized trials RoB 2.
The risk of bias by domain as well as overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review. The link in the column "Full description" provides access to the general characteristics of the study.
We acknowledge that we may have been unable to extract some information from pre-prints, as they represent preliminary forms of scientific communication.