Pharmacologic treatments for covid-19 patients

Sotrovimab vs Placebo


Outpatients

Forest plots
(last update: 2022-04-03)

Summary of findings
(last update: 2022-09-20)

Hospitalized patients

Forest plots
(last update: 2022-01-04)

Summary of findings
(last update: 2022-09-14)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=416

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04501978
ACTIV-3
Self WH, Lancet Infect Dis, 2021
Full text
Commentary
Commentary
Mixed

Sotrovimab

BRII-196/BRII-198

Sotrovimab

Placebo

Placebo

BRII-196/BRII-198

RCT Patients with confirmed COVID-19 (mild-moderate) admitted to 43 centres in Denmark, Poland, Switzerland, and USA N=546
Low
Details

Full description

NCT04545060
COMET-ICE
Gupta A, JAMA, 2022
Full text
Full text
Full text
Full text
Commentary
Commentary
Commentary
Commentary
Private

Sotrovimab

Placebo

RCT Outpatients with confirmed COVID-19 (mild) and at high risk for Covid-19 progression, treated by 57 centers in the USA, Canada, Brazil, Spain and Peru. N=1057
Some concerns
Details

Full description