Pharmacologic treatments for covid-19 patients

Hydroxychloroquine + Azithromycin vs Standard care/Placebo

This comparison will not be updated. Last search date 28 Feb, 2022.


Outpatients

Forest plots
(last update: 2021-09-24)

Summary of findings
(last update: 2022-03-30)

Hospitalized patients

Forest plots
(last update: 2021-06-24)

Summary of findings
(last update: 2022-03-30)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=33

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
Updated
RBR-95yjmq
Rodrigues C, Int J Antimicrob Age, 2021
Full text
Commentary
Private

HCQ+AZM

Placebo

RCT Outpatients with confirmed COIVD-19 (symptomatic, mild) treated by a single center in Brazil N=84
Some concerns
Details

Full description

NCT04322396, EudraCT 2020-001198-55
ProPAC-COVID
Sivapalan P, Eur Respir J, 2021
Full text
Commentary
Mixed

HCQ+AZM

Placebo

RCT Patients with confirmed COVID-19 (mild-severe) admitted to 6 centers in Denmark N=117
Low
Details

Full description

NCT04349592
Q-PROTECT
Omrani A, EClinicalMedicine, 2020
Full text
Commentary
Public/non profit

HCQ+AZM

Hydroxychloroquine

HCQ+AZM

Placebo

Placebo

Hydroxychloroquine

RCT Outpatients with confirmed COVID-19 (mild) treated by 2 centers in Qatar N=456
Some concerns
Details

Full description

NCT04322123
Cavalcanti AB, N Engl J Med, 2020
Full text
Commentary
Mixed

HCQ+AZM

Hydroxychloroquine

Hydroxychloroquine

Standard care

RCT Patients with suspected or confirmed COVID-19 (mild-moderate) admitted to 55 centers in Brazil N=667
Some concerns
Details

Full description