Outcome |
Relative effect (95% CI) |
Absolute effect (95% CI)1 |
Certainty of the Evidence (GRADE) |
Viral negative conversion D7 |
RR: 1.67 (1.22 - 2.30) |
56 more per 1000 (from 18 more to 109 more)
|
Low certainty
Reasons to downgrade
Risk of bias: Not serious Inconsistency: Not serious Indirectness: Serious studies from a single country, therefore results in this population might not be generalizable to other settings. Imprecision: Serious due to low number of participants
|
2 trials
Dougan M, 2021 (1); Gottlieb R, 2021
1310 participants
|
|
Bamlanivimab+Etesevimab (LY-CoV555+LY-CoV016) 140 per 1,000 (103 - 193) |
Placebo 84 per 1,000 |
|
Clinical improvement D28 |
RR: 1.20 (0.99 - 1.46) |
109 more per 1000 (from 5 fewer to 251 more)
|
Low certainty
Reasons to downgrade
Risk of bias: Not serious Inconsistency: Not serious Indirectness: Serious despite a multicentre design this is a single study from a single country, therefore results in this population might not be generalizable to other settings. Imprecision: Serious due to low number of participants
|
1 trials
Gottlieb R, 2021
275 participants
|
|
Bamlanivimab+Etesevimab (LY-CoV555+LY-CoV016) 656 per 1,000 (541 - 798) |
Placebo 547 per 1,000 |
|
Clinical improvement D60 |
Outcome not yet measured or reported
|
|
WHO progression score (level 7 or above) D28 |
Outcome not yet measured or reported
|
|
WHO progression score (level 7 or above) D60 |
Outcome not yet measured or reported
|
|
All-cause mortality D28 |
RR: 0.05 (0.01 - 0.39) |
14 fewer per 1000 (from 15 fewer to 9 fewer)
|
Moderate certainty
Reasons to downgrade
Risk of bias: Not serious Inconsistency: Not serious Indirectness: Not serious Imprecision: Serious due to low number of participants/events
|
3 trials
Dougan M, 2021 (1); Dougan M, 2021(2); Gottlieb R, 2021
2092 participants
|
|
Bamlanivimab+Etesevimab (LY-CoV555+LY-CoV016) 1 per 1,000 (0 - 6) |
Placebo 15 per 1,000 |
|
All-cause mortality D60 |
Outcome not yet measured or reported
|
|
Adverse events
|
RR: 0.91 (0.65 - 1.28) |
12 fewer per 1000 (from 47 fewer to 38 more)
|
Low certainty
Reasons to downgrade
Risk of bias: Not serious Inconsistency: Not serious Indirectness: Not serious Imprecision: Very serious due to very wide confidence interval consistent with the possibility for benefit and the possibility for harm and low number of participants
|
3 trials
Dougan M, 2021 (1); Dougan M, 2021 (2); Gottlieb R, 2021
2092 participants
|
|
Bamlanivimab+Etesevimab (LY-CoV555+LY-CoV016) 123 per 1,000 (88 - 173) |
Placebo 135 per 1,000 |
|
Serious adverse events
|
RR: 1.43 (0.59 - 3.45) |
4 more per 1000 (from 3 fewer to 21 more)
|
Low certainty
Reasons to downgrade
Risk of bias: Not serious Inconsistency: Not serious Indirectness: Not serious Imprecision: Very serious due to very wide confidence interval consistent with the possibility for benefit and the possibility for harm and low number of participants
|
3 trials
Dougan M, 2021 (1); Dougan M, 2021 (2); Gottlieb R, 2021
2092 participants
|
|
Bamlanivimab+Etesevimab (LY-CoV555+LY-CoV016) 12 per 1,000 (5 - 29) |
Placebo 9 per 1,000 |
|
Hospitalisation or death * |
RR: 0.23 (0.11 - 0.49) |
50 fewer per 1000 (from 58 fewer to 33 fewer)
|
Moderate certainty
Reasons to downgrade
Risk of bias: Not serious Inconsistency: Not serious Indirectness: Not serious Imprecision: Serious due to low number of participants/events
|
2 trials
Dougan M, 2021 (1); Dougan M, 2021 (2)
1817 participants
|
|
Bamlanivimab+Etesevimab (LY-CoV555+LY-CoV016) 15 per 1,000 (7 - 32) |
Placebo 65 per 1,000 |
|
1The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
CI: Confidence interval; RR: Risk ratio
GRADE Working Group grades of evidence
High certainty: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect