Pharmacologic treatments for covid-19 patients

Lopinavir-Ritonavir vs Hydroxychloroquine

This comparison will not be updated. Last search date 28 Feb, 2022.


Outpatients

Forest plots
(last update: 2021-05-27)

Hospitalized patients

Forest plots
(last update: 2021-07-29)

Summary of findings
(last update: 2022-03-14)

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Permanent URL for this comparison: https://covid-nma.com/living_data/index.php?comparison=225

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT02735707
Arabi Y, Intensive Care Med, 2021
Full text
Commentary
Mixed

Lopinavir-Ritonavir

Hydroxychloroquine

HCQ+LPV/r

Lopinavir-Ritonavir

Lopinavir-Ritonavir

Hydroxychloroquine

Standard care

Standard care

Standard care

Hydroxychloroquine

HCQ+LPV/r

HCQ+LPV/r

RCT Patients with suspected or confirmed COVID-19 (critical) admitted to a multiple centers in Australia, Canada, France, Germany, Ireland, Netherlands, New Zealand, Portugal, Saudi Arabia, UK, and USA N=726
Some concerns
Details

Full description

NCT04403100
TOGETHER
Reis G, JAMA, 2021
Full text
Commentary
Commentary
Public/non profit

Lopinavir-Ritonavir

Hydroxychloroquine

Lopinavir-Ritonavir

Placebo

Placebo

Hydroxychloroquine

RCT Outpatients with confirmed COVID-19 (mild) treated at local public health facilities in 10 cities in Brazil N=685
Some concerns
Details

Full description

NCT04315948
DisCoVeRy
Ader F, medRxiv, 2022
Full text
Full text
Commentary
Commentary
Commentary
Mixed

Lopinavir-Ritonavir

LPV/r+IFN beta-1a

Hydroxychloroquine

Lopinavir-Ritonavir

Lopinavir-Ritonavir

LPV/r+IFN beta-1a

Standard care

Standard care

Standard care

LPV/r+IFN beta-1a

Hydroxychloroquine

Hydroxychloroquine

RCT Patients with confirmed COVID-19 (mild-critical) admitted to 32 centers in France and Luxembourg. N=603
Some concerns
Details

Full description