Pharmacologic treatments for covid-19 patients

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Vitamin D vs Standard care/Placebo

Forest plots were updated on December 4th, 2020.
The Evidence profile and Summary of Findings table were updated on December 6th, 2020Forest plots

Evidence profile

Summary of findings


Trial Comparisons Design Participants Sample size Overall risk of bias
Primary outcome
Full description
Treatment 1 Treatment 2
NCT04366908
Entrenas Castillo M, J Steroid Biochem Mo, 2020
Full text
Commentary
Calcifediol Standard care RCT Patients with confimed COVID-19 (moderate-severe) admitted to a single center in Spain N=76
Some concerns
Details

Full description

NCT04459247
Rastogi A, Postgrad Med J, 2020
Full text
Commentary
; Commentary
Cholecalciferol Placebo RCT Patients with confirmed COVID-19 (symptomatic or asymptomatic mild) admitted to a single center in India N=40
*
Details

Full description

NCT04449718
Murai I, medRxiv, 2020
Full text
Commentary
; Commentary
Cholecalciferol Placebo RCT Patients with COVID-19 (mild-severe) admitted to 2 centres in Brazil N=240
Some concerns
Details

Full description

Kemran S M medRxiv, 2020 trial was not included in our data analysis due to unconvincing randamization that was not clarified by authors quote " Randomization rules were designed by Dr. xxx together with principal investigators and implemented by an independent statistician who was not involved in data analysis. Stratified random sampling was applied to stratify all eligible patients according to age, gender and comorbidities. Computerized random number generator was used and allocation was done in 2:1 sequence. Cards with each group assignment number randomly generated by computer were placed in sequentially numbered envelopes that were opened as the patients were enrolled".