Pharmacologic treatments for covid-19 patients

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Remdesivir vs Standard Care/Placebo


Hospitalized patients

Forest plots
(last update: 2021-07-29)

Summary of findings
(last update: 2021-07-30)

Trial Comparisons Design Participants Sample size Overall risk of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04257656
Wang Y, Lancet, 2020
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Commentary
Remdesivir Placebo RCT Patients with confirmed COVID-19 (severe) admitted to 10 centers in China N=237
Some concerns
Details

Full description

NCT04280705
Beigel JH, N Engl J Med, 2020
Full text
Commentary
Remdesivir Placebo RCT Patients with confirmed COVID-19 (mild-critical) admitted to 60 centers in 10 countries N=1062
Some concerns
Details

Full description

NCT04292730
Spinner CD, JAMA, 2020
Full text
Commentary
Remdesivir 5 days Standard care RCT Patients with COVID-19 (mild-severe) admitted to 105 centers in the USA, Europe and Asia N=596
Some concerns
Details
Full description
Remdesivir 10 days Standard care
Remdesivir 5 days Remdesivir 10 days
ISRCTN83971151; NCT04315948
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Remdesivir Standard care RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries N=5475
Low
Details

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NCT04321616
Barratt-Due A, Ann Intern Med, 2021
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Full text
Commentary
Remdesivir Standard care RCT Patients with confirmed COVID-19 (unclear severity) admitted to 23 centers in Norway N=101
Low
Details

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N/A
Mahajan L, Indian J Anaesth, 2021
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Commentary
Remdesivir Standard care RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in India. N=82
High
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NCT04315948, EudraCT2020-000936-23
Ader F, SSRN, 2021
Full text
Commentary
Remdesivir Standard care RCT Patients with confirmed COVID-19 (mild-critical) admitted to 48 centers in France (39), Belgium (3), Portugal (2), Austria (3), and Luxembourg (1). N=857
Some concerns
Details

Full description