Pharmacologic treatments for covid-19 patients

Remdesivir vs Standard Care/Placebo


Outpatients

Forest plots
(last update: 2022-04-15)

Summary of findings
(last update: 2022-04-27)

Hospitalized patients

Forest plots
(last update: 2022-04-15)

Summary of findings
(last update: 2022-05-03)

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Trial Funding Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Treatment 1 Treatment 2
NCT04330690
Ali K, CMAJ, 2022
Full text
Commentary
Commentary
Public/non profit

Remdesivir

Standard care

RCT Patients with confirmed COVID-19 (mild-critical) admitted to 52 centers in Canada N=1282
High
Details

Full description

NCT04501952; EudraCT 2020-003510-12.
Gottlieb RL, N Engl J Med, 2021
Full text
Commentary
Commentary
Private

Remdesivir

Placebo

RCT Outpatients with confirmed COVID-19 (mild) treated at 64 centers in Denmark, Spain, UK and USA. N=584
Some concerns
Details

Full description

NCT04345419
Abd-Elsalam S, Am J Trop Med Hyg, 2021
Full text
Commentary
Not reported/unclear

Remdesivir

Standard care

RCT Patients with confirmed COVID-19 (mild-moderate-severe) admitted to two centres in Egypt N=209 N/A

Full description

NCT04315948, EudraCT2020-000936-23
DisCoVeRy
Ader F, medRxiv, 2022
Full text
Full text
Full text
Commentary
Commentary
Public/non profit

Remdesivir

Standard care

RCT Patients with confirmed COVID-19 (mild-critical) admitted to 48 centers in France (39), Belgium (3), Portugal (2), Austria (3), and Luxembourg (1). N=857
Some concerns
Details

Full description

N/A
Mahajan L, Indian J Anaesth, 2021
Full text
Commentary
No specific funding

Remdesivir

Standard care

RCT Patients with confirmed COVID-19 (moderate-severe) admitted to a single center in India. N=82
High
Details

Full description

ISRCTN83971151; NCT04315948
SOLIDARITY (RDV)
Pan H, N Engl J Med, 2020
Full text
Full text
Commentary
Mixed

Remdesivir

Standard care

RCT Patients with COVID-19 (mild-critical) admitted to 405 centers in 30 countries N=5475
Low
Details

Full description

NCT04292730
Spinner CD, JAMA, 2020
Full text
Commentary
Private

Remdesivir

Remdesivir

Remdesivir

Standard care

Standard care

Remdesivir

RCT Patients with COVID-19 (mild-severe) admitted to 105 centers in the USA, Europe and Asia N=596
Some concerns
Details

Full description

NCT04280705
Beigel JH, N Engl J Med, 2020
Full text
Commentary
Public/non profit

Remdesivir

Placebo

RCT Patients with confirmed COVID-19 (mild-critical) admitted to 60 centers in 10 countries N=1062
Some concerns
Details

Full description

NCT04257656
Wang Y, Lancet, 2020
Full text
Commentary
Mixed

Remdesivir

Placebo

RCT Patients with confirmed COVID-19 (severe) admitted to 10 centers in China N=237
Some concerns
Details

Full description

NCT04321616
NOR-SOLIDARITY
Barratt-Due A, Ann Intern Med, 2021
Full text
Full text
Commentary
Mixed

Remdesivir

Standard care

RCT Patients with confirmed COVID-19 (unclear severity) admitted to 23 centers in Norway N=101
Low
Details

Full description