More details about outcomes and disease severity
List of outcomes:
Incidence of participants with positive test for SARS-CoV-2 infection by RT-PCR OR Nucleic acid amplification testing (NAAT) or other validated test (symptomatic or asymptomatic)
Incidence of symptomatic COVID-19 confirmed with positive test for SARS-CoV-2 infection by RT-PCR OR NAAT
Incidence of hospitalization or death due to confirmed COVID-19
Severe or critical disease defined according to the WHO definition or as reported by trialists (collect definition)
Incidence of any adverse events
Incidence of serious adverse events (SAEs)
Incidence of local adverse events (D7)
Incidence of systemic adverse events (D14)
Incidence of withdrawal due to adverse events
For phase 1-2 studies, we report on the general charecteristics and assess the risk of Bias for safety outcomes only.Results from phase1-2 studies are included in forest plots for the chosen vaccine dose and schedule.
For phase 2-3 trials we provide the evidence synthesis with forest plots and summary of findings table and evidence profile.
Results for each vaccine comparisons are the summary of evidence from the latest study report results.