Study registration: *
Publication Tang P, medRxiv, 2021
Dates: 2020-12-21 to 2021-07-21
Funding: Mixed (Biomedical Research Program and the Biostatistics, Epidemiology, and Biomathematics Research Core, the Ministry of Public Health and Hamad Medical Corporation, Qatar Genome Programme. )
Conflict of interest: no COI (First and last authors and trial statisticians declare no competing interests. Dr. Butt has received institutional grant funding from Gilead Sciences unrelated to the work presented in this paper. )