Study registration: ISRCTN21086382
Publication Pouwels K, Nat Med, 2021
Dates: 2020-12-01 to 2021-08-01
Funding: Mixed (Department of Health and Social Care (UK), National Institute for Health Research Health Protection Research Unit (NIHR HPRU), Public Health England, NIHR Oxford Biomedical Research Centre, Huo Family Foundation,Medical Research Council UK, Wellcome, Robertson Fellowship.)
Conflict of interest: Yes (KBP and ASW are employees of the University of Oxford, but not involved in the development or production of the vaccine. ASW also received grants from Medical Research Council UK during the conduct of the study.)

Methods

Study design:Cohort
Description of participants: Adults from households randomly selected across the UK.
Inclusion criteria:
  • Individuals aged 18 years or older (that is, those who were eligible for vaccination)
  • Sll visits with positive or negative swab results from 1 December 2020 to 1 August 2021.

Exclusion criteria:
  • *

Follow-up duration (months): 9
Vaccines:
  • 1 or 2 doses of ChAdOx1-S
  • 1 or 2 doses of mRNA-1273
  • 1 or 2 doses of BNT162b2
Variant description :
Variant name: Delta
Evidence: Indirect evidence (prevalence of variant in the population: 61 to 99)
Documents
available

Protocol

Yes. In English

Statistical plan

Yes

Data-sharing stated: Yes, Data are still being collected for the COVID-19 Infection Survey. De-identified study data are available for access by accredited researchers in the ONS Secure Research Service (SRS).
Data accessibility: contact Research.Support@ons.gov.uk or visit the SRS website, https://www.ons.gov.uk/aboutus/whatwedo/statistics/requestingstatistics/approvedresearcherscheme
General comment This is a strong, sophisticated analysis, although uncontrolled confounding cannot be ruled out given the observational nature of the data.