• Family history of seizure, epilepsy, brain or mental disease - Participant that has an allergic history to any ingredient of vaccines - Woman who is pregnant, breast-feeding or positive in pregnancy test on day of enrollment, or is planning to be pregnant during the next 6 months - Any acute fever disease or infections - Have a medical history of SARS - Have serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, severe hypertension and not well-controlled - Major chronic illness, such as asthma, diabetes, or thyroid disease, and not well-controlled - Hereditary angioneurotic edema or acquired angioneurotic edema - Urticaria in last one year - Asplenia or functional asplenia - Platelet disorder or other bleeding disorder may cause injection contraindication - Faint at the sight of blood or needles. - Prior administration of immunodepressant or corticosteroids, antianaphylaxis treatment, cytotoxic treatment in last 6 months - Prior administration of blood products in last 4 months - Prior administration of other research medicines in last 1month - Prior administration of attenuated vaccine in last 1 month - Prior administration of subunit vaccine or inactivated vaccine in last 14 days - Being treated for tuberculosis - Any condition that in the opinion of the investigators may interfere with the evaluation of study objectives

Protocol

Yes. In English

Statistical plan

Yes

Data-sharing stated: Yes, beginning 3 months and ending 1 year after publication.
Data accessibility: Researchers who provide a scientifically sound proposal will be allowed access to the individual participant data. Proposals should be directed to jszfc@vip.sina.com or cw0226@foxmail.com.