COVID-19 vaccine effectiveness
(Randomized evidence)

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Trial Type Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
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Intervention 1 Intervention 2
ISRCTN69254139, EudraCT: 2020-005085-33
AstraZeneca+University of Oxford; Pfizer/BioNTech+Fosun Pharma
Liu X, Lancet, 2021 ()

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RNA based vaccine

1 dose ChAdOx1/ 1 dose BNT162b2

1 dose BNT162b2 /1 dose ChAdOx1

2 doses ChAdOx1

2 doses BNT162b2

Phase 2
Adults 50 years or older with no previous SARS-CoV-2 infection, no or well-controlled mild-moderate comorbidities and HIV-negative in 8 centers in the UK N=463
Some concerns

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