COVID-19 vaccine effectiveness
(Randomized evidence)

Methods

Protocol

Analyses are updated every two weeks

meta-COVID

Perform your own analysis using COVID-NMA data, create and download your forest plots by clicking below:

go to metacovid

Vaccine types

Vaccine efficacy and safety for vaccine vs placebo / no vaccine (forest plots)

Vaccine efficacy and safety for vaccine vs vaccine (forest plots)

Vaccine efficacy and safety against variants of concern (forest plots)

Vaccine efficacy, immunogenicity and safety of heterologous vs homologous vaccination (tables)

Vaccine efficacy, immunogenicity and safety of booster vs no booster (tables)

Vaccine efficacy, immunogenicity and safety of booster VS booster (tables)

Search studies

Search by Vaccine name Author Registration number
Trial Type Comparisons Design Participants Sample size Overall risk
of bias
Highest assessment
Full description
Intervention 1 Intervention 2
CTRI/2021/01/030416
Zydus Cadila
Khobragade A, Lancet , 2022

Full text
Commentary
DNA based vaccine

ZyCoV-D 2mg D0/28/56

Placebo

RCT
Phase 3
Healthy adults and adolescents aged (≥12 years) with no previous history of COVID-19 at 49 centers in India. N=27703
Some concerns
Details

Full description

NCT04642638
Inovio Pharmaceuticals
Mammen Jr M, medRxiv, 2021

Full text
Commentary
Commentary
DNA based vaccine

INO-4800 1mg

INO-4800 2mg

Placebo 1

Placebo 2

RCT
Phase 2
Healthy adult volunteers SARS-CoV-2 seronegative at high risk of infection at 16 locations in the USA. N=201
Some concerns
Details

Full description