Observational studies

Pharmacologic treatments

Below, we list all observational studies identified

Title Study reference Full text
Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection in a multi-site UK acute Hospital Trust Bean D, medRxiv, 2020 Full text
Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial Bian H, MedRxiv, 2020 Full text
First Clinical Study Using HCV Protease Inhibitor Danoprevir to Treat Naive and Experienced COVID-19 Patients Chen H, medRxiv, 2020 Full text
Key to successful treatment of COVID-19: accurate identification of severe risks and early intervention of disease progression Chen M, medRxiv, 2020 Full text
The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin Chorin E, medRxiv, 2020 Full text
Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study Deng L, J Infect, 2020 Full text
Effectiveness of convalescent plasma therapy in severe COVID-19 patients Duan K, Proc Natl Acad Sci USA, 2020 Full text
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Feng Z, medRxiv, 2020 Full text
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Gautret P, Int J Antimicrob Agents, 2020 Full text
Compassionate Use of Remdesivir for Patients with Severe Covid-18 Gautret P, Travel Med Infect Dis, 2020 Full text
Compassionate Use of Remdesivir for Patients with Severe Covid-19 Grein J, N Eng J Med, 2020 Full text
Use of siltuximab in patients with COVID-19 pneumonia requiring ventilatory support Gritti G, medRxiv, 2020 Full text
Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Patients in Wuhan, China Hu L, medRxiv, 2020 Full text
Impact of Corticosteroid Treatment in Patients with Coronavirus Lei Z, Med J Aust, 2020 Full text
Disease 2019 Leng Z, Aging Dis, 2020 Full text
Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression Liu F, Int J Infect Dise, 2020 Full text
The effect of Arbidol Hydrochloride on reducing mortality of Covid-19 patients: a retrospective study of real world date from three hospitals in Wuhan Liu Q,medRxiv,2020 Full text
Tocilizumab treatment in COVID-19: a single center experience Luo P, J Med Virol, 2020 Full text
An experimental trial of recombinant human interferon alpha nasal drops to prevent coronavirus disease 2019 in medical staff in an epidemic area Meng Z, medRxiv, 2020 Full text
No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection Molina JM, Med Mal Infect, 2020 Full text
Heparin therapy improving hypoxia in COVID-19 patients - a case series Negri EM, medRxiv, 2020 Full text
Experience with Hydroxychloroquine and Azithromycin in the COVID-19 Pandemic: Implications for QT Interval Monitoring Ramireddy A, medRxiv, 2020 Full text
Clinical Efficacy of Intravenous Immunoglobulin Therapy in Critical Patients with COVID-19: A multicenter retrospective cohort study Shao Sr. Z, medRxiv, 2020 Full text
Evaluation of Antiviral Therapies for Coronavirus Disease 2019 (COVID-19) Pneumonia in Shanghai, China Shi X, J Med Virol, 2020 Full text
Clinical observations of low molecular weight heparin in relieving inflammation in COVID-19 patients: A retrospective cohort study Shi, medRxiv, 2020 Full text
No Clear Benefit to the Use of Corticosteroid as Treatment in Adult Patients with Coronavirus Disease 2019 : A Retrospective Cohort Study Wang D, medRxiv, 2020 Full text
Early, low-dose and short-term application of corticosteroid treatment in patients with severe COVID-19 pneumonia: single-center experience from Wuhan, China Wang Y, MedRxiv, 2020 Full text
Plasminogen improves lung lesions and hypoxemia in patients with COVID-19 Wu Y, Int J Med, 2020 Full text
Adjuvant corticosteroid therapy for critically ill patients with COVID-19 Xiaofan L, medRxiv, 2020 Full text
Effective Treatment of Severe COVID-19 Patients with Tocilizumab Xu X, ChinaXiv, 2020 Full text
Factors associated with prolonged viral shedding and impact of Lopinavir/Ritonavir treatment in patients with SARS-CoV-2 infection Yan D, medRxiv, 2020 Full text
Clinical efficacy of lopinavir/ritonavir in the treatment of Coronavirus disease 2018 Ye X-T, Eur Rev Med Pharmacol Sci, 2020 Full text
Potential of Arbidol for Post-exposure Prophylaxis of COVID-19 Transmission Zhang J, chinaXiv, 2020 Full text
Risk-adapted Treatment Strategy For COVID-19 Patients Zheng Ch, Int J Inf Dis, 2020 Full text
Interferon-a2b treatment for COVID-19 Zhou Q, medRxiv, 2020 Full text
Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia Zhou W, Signal Transduct Target Ther, 2020 Full text
Arbidol Monotherapy is Superior to Lopinavir/ritonavir in Treating COVID-19 Zhu Z, J infect, 2020 Full text
Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19 Zie Y, J Infect, 2020 Full text
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19 Sengupta V, Stem cells and developmen, 2020 Full text
Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study. Cai Q, Engineering, 2020 Full text
Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in severe patients with COVID-19. Sciascia S, Clinical and experimental rheumatology, 2020 Full text
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19). Mercuro N, JAMA cardiology, 2020 Full text
Tocilizumab for the Treatment of Severe COVID-19 Rand A, Journal of medical virology, 2020 Full text
Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy ToniatI P, Autoimmunity reviews , 2020 Full text
Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: A retrospective study. Lian N, Clinical microbiology and infection, 2020 Full text
Full-length title: Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France. Million M, Médecine des voyages et maladies infectieuses, 2020 Full text
Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients Klopfenstein T, Medecine et maladies infectieuses, 2020 Full text
Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State Rosenberg E, JAMA, 2020 Full text
Tocilizumab for Treatment of Severe COVID-19 Patients: Preliminary Results from SMAtteo COvid19 REgistry (SMACORE) Colaneri M, Microorganisms, 2020 Full text
Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post_treatment hospitalisation status. Antinori S, Basic research in cardiology, 2020 Full text
Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia. Capra R, European journal of internal medicine, 2020 Full text
Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19  Yu B, Science China. Life sciences, 2020 Full text
Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients Carlucci P, medRxiv, 2020 Full text
Treatment Response to Hydroxychloroquine, Lopinavir/Ritonavir, and Antibiotics for Moderate COVID 19: A First Report on the Pharmacological Outcomes from South Korea Kim M, medRxiv, 2020 Full text
Early Short Course Corticosteroids in Hospitalized Patients with COVID-19. Fadel R, Clinical infectious diseases, 2020 Full text
Rescue Therapy for Severe COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS) with Tissue Plasminogen Activator (tPA): A Case Series. Barrett C, The journal of trauma and acute care surgery, 2020 Full text
Timing of non-pharmaceutical interventions to mitigate COVID-19 transmission and their effects on mobility: A cross-country analysis Summan A, medRxiv, 2020 Full text
Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis. Chroboczek T, medRxiv, 2020 Full text
Systemic corticosteroids show no benefit in severe and critical COVID-19 patients in Wuhan, China: A retrospective cohort study Wu J, medRxiv, 2020 Full text
Arbidol/IFN-?2b Therapy for Patients With Corona Virus Disease 2019: A Retrospective Multicenter?Cohort?Study Xu P, Microbes and infection, 2020 Full text
Effects of methylprednisolone use on viral genomic nucleic acid negative conversion and CT imaging lesion absorption in COVID-19 patients under 50 years old Gong y, Journal of medical virology, 2020 Full text
Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial. Zhu F, Lancet, 2020 Full text
Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19. Pianta L, European archives of oto-rhino-laryngology, 2020 Full text
Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy. Morena V, European journal of internal medicine, 2020 Full text

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