Trial N/A
Publication Magagnoli J, Med, 2020
Dates: 3/9/2020 to 4/28/2020

Methods
Non-randomized study
Location : Multicenter / USA
Follow-up duration (days): 51
Inclusion criteriaPatients with laboratory confirmed SARS-CoV-2 infection in an inpatient setting. Patients were included in the study if their information included 1) a body mass index, 2) vital signs during an encounter (temperature, heart rate and blood pressure), and 3) either discharged, died in hospital or were currently hospitalized as of the study end date.
Exclusion criteriaExclusion Criteria: Patients were excluded if they did not meet these criteria.
Type of analysisPropensity score with Multivariate logistic regression
Interventions
Treatment 1
Hydroxychloroquine + Azithromycin
Definition of Standard care: All patients received standard supportive management
Treatment 2
Hydroxychloroquine
Definition of Standard care: All patients received standard supportive management
Participants
N analyzed
271 participants (n1=113 / n2= 158)
Characteristics of participants
N=368
Mean age : NR
368 males
Severity : Mild: n=* / Moderate: n=*/ Severe: n=* Critical: n=*
Primary outcome
In the register
NR
In the report
The study outcomes are the result of the hospitalization (discharge or death), whether ventilation was required, the type of ventilation and the result of hospitalization among patients requiring ventilation. Mechanical ventilation included pa- tient
Documents
avalaible

Protocol

No

Statistical plan

No

Data-sharing stated

No
Risk of bias
Overall
The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review
Serious
Notes This is a quasi-experimental study. The preprint extraction was updated on 16/07/2020 with the published report and supplementary file. The baseline data are extracted from Table 1. They concern the unadjusted sample (n=807). The time to death HR extracted from Table 3 concerns the Prospensity score with Cox proportiional hazards regression adjusted sample. No registration, protocol or SAP were available.