Patient or population:
Setting:
Intervention:
Comparison:
Summary of findings: | ||||||
CoronaVac compared to Placebo for vaccination against COVID-19 |
||||||
Patient or population:
Setting:
Intervention:
Comparison:
|
||||||
Outcomes |
Anticipated absolute effects* (95% CI) |
Relative effect |
№ of participants
|
Certainty of the evidence |
Comments |
|
---|---|---|---|---|---|---|
Risk with Placebo |
Risk with CoronaVac |
|||||
Incidence of participants with positive test for SARS-CoV-2 infection - not reported
|
-
|
-
|
-
|
-
|
-
|
outcome not yet measured or reported
|
Incidence of symptomatic COVID-19 confirmed with positive test for SARS-CoV-2
c
|
2,398 per 100,000
|
719 per 100,000
(240 to 2,110) |
Rate ratio 0.30
(0.10 to 0.88) |
19852
(2 RCTs) d |
⨁⨁◯◯
LOW b,e,f |
Vaccine efficacy 50.7% (95%CI 35.9% to 62.0%) and 83.5% (95%CI: 65.4% to 92.1%)
|
Severe or critical disease due to COVID-19
c
|
134 per 100,000
|
0 per 100,000
(0 to 112) |
Rate ratio 0.000
(0.000 to 0.831) |
16729
(2 RCTs) d |
⨁⨁◯◯
LOW b,f,g |
Vaccine efficacy 100% (95% CI 16.9% to 100.0%) and not reported
|
All-cause mortality
h
|
20 per 100,000
|
10 per 100,000
(1 to 113) |
RR 0.50
(0.05 to 5.52) |
22610
(2 RCTs) d |
⨁◯◯◯
VERY LOW f,i |
|
Any adverse events
j
|
53,362 per 100,000
|
58165 per 100,000
(57,098 to 59,232) |
RR 1.09
(1.07 to 1.11) |
23036
(4 RCTs) k |
⨁⨁⨁◯
MODERATE f |
|
Serious adverse events
h
|
369 per 100,000
|
365 per 100,000
(232 to 572) |
RR 0.99
(0.63 to 1.55) |
22610
(2 RCTs) d |
⨁◯◯◯
VERY LOW f,i |
|
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk ratio |
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GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect |