Patient or population:
Setting:
Intervention:
Comparison:
Summary of findings: | ||||||
ChAdOx1 compared to MenACWY for vaccination against COVID-19 |
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Patient or population:
Setting:
Intervention:
Comparison:
|
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Outcomes |
Anticipated absolute effects* (95% CI) |
Relative effect |
№ of participants
|
Certainty of the evidence |
Comments |
|
---|---|---|---|---|---|---|
Risk with MenACWY |
Risk with ChAdOx1 |
|||||
Incidence of participants with positive test for SARS-CoV-2 infection
b,c
|
4,033 per 100,000
|
1855 per 100,000
(1,532 to 2,218) |
Rate ratio 0.46
(0.38 to 0.55) |
17177
(1 RCT) d |
⨁⨁⨁◯
MODERATE e,f |
Vaccine efficacy 54.10% (95%CI 44.70% to 61.90%)
|
Incidence of symptomatic COVID-19 confirmed with positive test for SARS-CoV-2
b,c
|
2,890 per 100,000
|
954 per 100,000
(752 to 1,243) |
Rate ratio 0.33
(0.26 to 0.43) |
17177
(1 RCT) d |
⨁⨁⨁◯
MODERATE e,f |
Vaccine efficacy 66.70% (95%CI 57.40% to 74.00%)
|
Incidence of hospitalization or death due to confirmed COVID-19
b,c
|
74 per 100,000
|
4 per 100,000
(0 to 65) |
RR 0.05
(0.00 to 0.88) |
24512
(1 RCT) d |
⨁⨁◯◯
LOW f,g |
|
Severe or critical disease due to COVID-19
b,h
|
9 per 100,000
|
3 per 100,000
(0 to 68) |
RR 0.33
(0.01 to 7.98) |
23745
(1 RCT) i |
⨁◯◯◯
VERY LOW f,j |
|
All-cause mortality
b,k
|
33 per 100,000
|
16 per 100,000
(3 to 89) |
RR 0.49
(0.09 to 2.66) |
24244
(1 RCT) i |
⨁◯◯◯
VERY LOW f,j |
|
Incidence of any adverse events
b,l
|
1,075 per 100,000
|
795 per 100,000
(602 to 1,032) |
RR 0.74
(0.56 to 0.96) |
23745
(1 RCT) i |
⨁⨁⨁◯
MODERATE f |
|
Incidence of serious adverse events (SAEs)
b,k
|
1,062 per 100,000
|
881 per 100,000
(679 to 1,136) |
RR 0.83
(0.64 to 1.07) |
24244
(1 RCT) i |
⨁⨁◯◯
LOW f,m |
|
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk ratio |
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GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect |