Trial NL9436 (Netherlands Trial Register)
Publication COVID-Compromise - Huygens S, medRxiv (2022) (preprint)
Primary outcome on the report: Occurrence of severe COVID-19 evaluated up until day 28 after treatment. Severe COVID-19 was defined as any of the following: (1) an indication for high-flow nasal oxygen, (2) need for mechanical ventilation, (3) lack of clinical improvement after at least seven days of observation after treatment or (4) readmission for PCR-confirmed COVID-19 within 28 days.

Note: The risk of bias by domain corresponds to the highest risk of bias among outcomes by domain.
The overall risk of bias corresponds to the overall highest risk of bias assessed among outcomes.