Trial NCT04505774
Publication ACTIV-4a - Berger JS, JAMA (2022) (published paper)
Primary outcome on the report: 1) Organ support–free days: evaluated on an ordinal scale that combined in-hospital death (assigned a value of −1) and, for those who survived to hospital discharge, the number of days free of respiratory or cardiovascular organ support up to day 21 of the index hospitalization (range, −1 to 21 days; higher scores indicate less organ support and better outcomes); 2) Major bleeding by 28 days (as defined by the International Society on Thrombosis and Hemostasis).

Note: The risk of bias by domain corresponds to the highest risk of bias among outcomes by domain.
The overall risk of bias corresponds to the overall highest risk of bias assessed among outcomes.