| Bias | Author's judgement | Support for judgement |
| Randomization |
Some concerns |
Quote: "patients
were randomly assigned in a 2:1 ratio to receive
Auxora plus standard of care or standard of care alone;
randomization was not center specific." Comment: No information on allocation sequence concealment was provided. |
| Deviations from intervention |
Some concerns |
Comment: Unblinded study.
No participant cross-over No information on review co-intervention of interest: anticoagulants. Antivirals, glucocorticoids and biologics were reported but not per arm for Arm A of the trial. Data were analyzed using intention-to-treat analysis. |
| Missing outcome data |
Low |
Comment: 26 randomized, 26 analyzed. Risk assessed to be low for outcomes. Mortality. Incidence of WHO score 7 and above. Time to WHO score 7 and above. |
| Measurement of the outcome |
Low |
Comment: Mortality is an observer-reported outcome not involving judgement. WHO Score 7 and above reflects decisions made by the intervention provider. However, we consider that the assessment of these outcomes cannot possibly be influenced by knowledge of the intervention assignment. Risk assessed to be low for outcome: Mortality. Incidence of WHO score 7 and above. Time to WHO score 7 and above. |
| Selection of the reported results |
Some concerns |
Comment: No protocol or statistical analysis plan were available. Risk assessed to be some concerns for outcomes. Mortality. Incidence of WHO score 7 and above. Time to WHO score 7 and above. |
| Overall risk of bias |
Some concerns |