| Bias | Author's judgement | Support for judgement |
| Randomization |
Some concerns |
Comment: Allocation sequence generated randomly. No information about the method used for concealment of the allocation sequence. |
| Deviations from intervention |
Some concerns |
Comment: Unblinded study.
No participant cross-over. No information on review co-interventions of interest: antivirals, glucocorticoids, anticoagulants and biologics. Best supportive care was also given to all participants and may have been different and influenced by the knowledge of assignment to the treatment group. Appropriate method of analysis was used; participants were analyzed according to their assigned intervention. |
| Missing outcome data |
Low |
Comment: 30 patients randomized/30 patients analyzed. There is little detail on how serious AEs were collected and if it was systematically done, and if there were missing outcomes. Risk assessed to be low for the outcomes: Mortality, time to death and serious adverse events. |
| Measurement of the outcome |
Low |
Comment: Outcomes include only observer-reported events not involving judgement.Some concerns for serious adverse events as it was not well defined and may have been deferentially reported between institutions and doctors. Risk assessed to be low for the outcomes: Mortality, time to death and serious adverse events. |
| Selection of the reported results |
Some concerns |
Comment: no protocol or statistical plan available. Risk assessed as some concerns for the outcomes: Mortality, time to death and serious adverse events |
| Overall risk of bias |
Some concerns |