Trial *
Publication Rasheed A, Le Infezioni in Medi, 2020
Primary outcome on the report: The end points for the current study were: First, the safety of the CP therapy within the first 3 hours post-transfusion by mainly monitoring the allergic reaction to CP. Second, the duration, in days, for the patients to convert to SARS-CoV-2 RNA-negative along with improvement in the signs and symptoms of the critical infection, namely relief of severe dyspnea, no need for ventilators or oxygen therapy, declin- ing in fever if any, declining in respiratory rate to less than 30/min, and increased oxygen satura- tion to more than 93% at rest, so patients can be discharged from RCU to the infectious disease ward; this duration is named the Recovery Time from Critical Illness (RTCI). Third, the survival or death of the patients.

Note: The risk of bias by domain corresponds to the highest risk of bias among outcomes by domain.
The overall risk of bias corresponds to the overall highest risk of bias assessed among outcomes.

Bias Author's judgement Support for judgement
Randomization
High 		Quote: “CP and control groups were generated using simple randomization method. The names of recruited 49 patients were printed on identical paper cards; then, randomly, cards were picked one by one giving sequential number. Accordingly, the first 21 odd numbers were assigned to CP group and the rest of even numbers were assigned to control group.”
Comment: Allocation sequence probably random. Allocation sequence probably not concealed.
Deviations from intervention
* 		Not assessed; no outcome data extracted due to lack of information on follow up timepoints. Pending contact with authors.
Missing outcome data
* 		Not assessed; no outcome data extracted due to lack of information on follow up timepoints. Pending contact with authors.
Measurement of the outcome
* 		Not assessed; no outcome data extracted due to lack of information on follow up timepoints. Pending contact with authors.
Selection of the reported results
* 		Not assessed; no outcome data extracted due to lack of information on follow up timepoints. Pending contact with authors.
Overall risk of bias
*