| Bias | Author's judgement | Support for judgement |
| Randomization |
Some concerns |
Quote: “Exploratory randomized and controlled study”
Comment: Allocation sequence probably random. No information on allocation concealment. |
| Deviations from intervention |
Some concerns |
Comment: No information on blinding.
No participant cross-over. No information on administration of co-interventions of interest: antivirals, corticosteroids, biologics and anticoagulants. Data were probably analyzed using intention-to-treat analysis. |
| Missing outcome data |
Low |
Comment: 30 patients randomized; 30 patients analyzed.
Risk assessed to be low for the outcomes: Mortality. Incidence of WHO score 6 and above. Incidence of WHO score 7 and above. Serious adverse events. |
| Measurement of the outcome |
Some concerns |
Comment: No information on blinding.
For the incidence of WHO score 7 and above, we consider that the assessment cannot possibly be influenced by knowledge of intervention assignment. Also, no serious adverse events were reported. Risk assessed to be low for the outcome: Mortality. Incidence of WHO score 7 and above. Serious adverse events. Incidence of WHO score 6 and above require clinical judgements and could be affected by knowledge of intervention receipt. Risk assessed to be some concerns for the outcomes: Incidence of WHO score 6 and above. |
| Selection of the reported results |
Some concerns |
Comment: Neither the protocol, statistical analysis plan or study registry were available.
Risk assessed to be some concerns for the outcomes: Mortality. Incidence of WHO score 6 and above. Incidence of WHO score 7 and above. Serious adverse events. |
| Overall risk of bias |
Some concerns |