| Bias | Author's judgement | Support for judgement |
| Randomization |
Some concerns |
Quote: "Patients were randomized in 1:1 allocation in two groups (group-A and group-B) which contains 50 patients"
Comment: No information on allocation sequence. No information on allocation concealment. Allocation sequence probably random. |
| Deviations from intervention |
Some concerns |
Quote: "prospective, open-label, randomized and double blind clinical trial"; "The participants of the placebo group were received a similar tablet without therapeutic effects"
Comment: Blinding unclear as no description provided and contradictory descriptions used in study. No information on cross-over (no flow chart) No information on administration of co-intervention of interest: antivirals, anticoagulants. biologics, corticosteroids. Data analyzed appropriately; participants analyzed according to their intervention assignment. |
| Missing outcome data |
Low |
Comment:100 patients randomized; 100 patients analyzed.
Risk assessed to be low for the outcome: Mortality. |
| Measurement of the outcome |
Low |
Comment: Unclear blinding
Mortality is observer-reported and not involving judgement. Risk assessed to be low for the outcome: Mortality. |
| Selection of the reported results |
Some concerns |
Comment: Neither the protocol nor the statistical analysis plan was available.
The prospective registry was available. The mortality outcome was not listed. Risk assessed to be some concerns for the outcome: Mortality. |
| Overall risk of bias |
Some concerns |