Note: The risk of bias by domain corresponds to the highest risk of bias among outcomes by domain.
The overall risk of bias corresponds to the overall highest risk of bias assessed among outcomes.
| Bias | Author's judgement | Support for judgement |
| Randomization |
Some concerns |
Quote: "Patients were randomly assigned following simple randomization procedures (computerized random numbers) to one of two treatment groups."
Comment: Allocation sequence random. No information on allocation concealment. |
| Deviations from intervention |
Some concerns |
Comment: There was no information reported whether the study was blinded.
No participant cross-over. No information on administration of co-interventions of interest: antivirals, corticosteroids, biologics, and anticoagulants were reported. Appropriate analysis method used; participants analyzed according to their assigned intervention. |
| Missing outcome data |
Low |
Comment: 24 patients randomized; 24 patients analyzed.
Risk assessed to be low for the outcome: Incidence of viral negative conversion |
| Measurement of the outcome |
Low |
Comment: Unblinded study
Viral negative conversion is an observer-reported outcome not involving judgement. Risk assessed to be low for the outcome: Incidence of viral negative conversion |
| Selection of the reported results |
Some concerns |
Comment: The trial registry, protocol and the statistical analysis plan were not available.
Risk assessed to be some concerns for the outcome: Incidence of viral negative conversion. |
| Overall risk of bias |
Some concerns |