| Bias | Author's judgement | Support for judgement |
| Randomization |
Some concerns |
Quote: "Patients were randomly assigned following simple randomization procedures (computerized random numbers) to one of two treatment groups."
Comment: Allocation sequence random. No information on allocation concealment. |
| Deviations from intervention |
Some concerns |
Comment: There was no information reported whether the study was blinded.
No participant cross-over. No information on administration of co-interventions of interest: antivirals, corticosteroids, biologics, and anticoagulants were reported. Appropriate analysis method used; participants analyzed according to their assigned intervention. |
| Missing outcome data |
Low |
Comment: 24 patients randomized; 24 patients analyzed.
Risk assessed to be low for the outcome: Incidence of viral negative conversion |
| Measurement of the outcome |
Low |
Comment: Unblinded study
Viral negative conversion is an observer-reported outcome not involving judgement. Risk assessed to be low for the outcome: Incidence of viral negative conversion |
| Selection of the reported results |
Some concerns |
Comment: The trial registry, protocol and the statistical analysis plan were not available.
Risk assessed to be some concerns for the outcome: Incidence of viral negative conversion. |
| Overall risk of bias |
Some concerns |