Trial *
Publication Winchester S, J Infect (2021) (published paper)
Funding: Private (SaNOtize Research & Development Corporation, Canada, through Metanoic Health Ltd., UK.)
Conflict of interest: *
Methods | |
RCT | |
Location :
Single center / UK Follow-up duration (days): 18 | |
Inclusion criteria |
|
Exclusion criteria | NR |
Interventions | |
Treatment
NONS 4 sprays (each 120–140μL of solution) nasally 5-6 times a day for 9 days. |
|
Control
Placebo | |
Participants | |
Randomized participants : NONS=40 Placebo=40 | |
Characteristics of participants N= 80 Mean age : NR 29 males Severity : Mild: n= 80/ Asymptomatic: n=14 Number of vaccinated participants: NR | |
Primary outcome | |
In the register NR | |
In the report NR | |
Documents available |
Protocol NR Statistical plan NR Data-sharing willing stated in the publication: Not reported |
Risk of bias Overall The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review |
Some concerns |
General comment | Only the published article was used in data extraction and assessment of risk of bias. No registry, protocol or statistical analysis plan was available. This was a small clinical trial reported only in a brief letter. |