Trial *
Publication Kumari P, Cureus, 2020 (published paper)
Dates: 2020-03-01 to 2020-07-30
Funding: Not reported/unclear
Conflict of interest: No
| Methods | |
| RCT Blinding: Unblinded | |
| Location :
Single center / Pakistan Follow-up duration (days): * | |
| Inclusion criteria | Patients who were admitted with severe COVID-19 infection diagnosed based on the national health guidelines of Pakistan
Guidelines: In adults, clinical signs of pneumonia (fever/ cough) plus, any of the following: Respiratory rate > 30 Severe respiratory distress SpO2 ≤ 90% on room air Chest X-ray involving >50% of lung fields |
| Exclusion criteria | Patients who needed mechanical ventilation within 12 hours of admission |
| Interventions | |
| Treatment
Vitamin C (*)Co-Intervention: Standard care |
|
| Control
Standard care Definition of Standard care: Standard therapy for COVID-19 infection, which included antipyretics, dexamethasone, and prophylactic antibiotics | |
| Participants | |
| Randomized 150 participants (n1=75 / n2= 75) | |
| Characteristics of participants N=150 Mean age : 52.5 * males Severity : Mild: n=0 / Moderate: n=0/ Severe: n=150 Critical: n=0 | |
| Primary outcome | |
| In the register NR | |
| In the report NR | |
| Documents available |
Protocol NR Statistical plan NR Data-sharing stated NR |
| Risk of bias Overall The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review |
* |
| General comment |
This study is pending contact with authors due to lack of information on outcome timepoints, and overall follow-up.
The published article was used in data extraction and risk of bias assessment. Trial registry, protocol, and statistical analysis plan were not available at the time of data extraction. The study reported on need for mechanical ventilation (12/75 vs. 15/75) and on overall mortality (7/75 vs. 11/75), however, these data have not been added to analyses because follow-up time-points were not reported. |