Trial *
Publication Podder C, IMC J Med Sci, 2020 (published paper)
Dates: 2020-05-01 to 2020-07-31
Funding: No specific funding (Self-financed)
Conflict of interest: No
Methods | |
RCT Blinding: Unblinded | |
Location :
Single center / Bangladesh Follow-up duration (days): 10 | |
Inclusion criteria | Consecutive RT-PCR positive eligible mild to moderate COVID-19 cases of more than 18 years of age, of both sexes |
Exclusion criteria | Known pre-existing hypersensitivity to Ivermectin, pregnant and lactating mothers, and patients taking other antimicrobials or hydroxychloroquine |
Interventions | |
Treatment
Ivermectin (200 mcg/kg)Co-Intervention: Standard care Duration : 1 day |
|
Control
Standard care Definition of Standard care: Symptomatic treatment which included antipyretics, cough suppressants, and capsule doxycycline (100 mg every 12 hours for seven days) to treat possible community-acquired pneumonia as part of the local working protocol. | |
Participants | |
Randomized * participants (n1=* / n2= *) | |
Characteristics of participants N=* Mean age : NR 44 males Severity : Mild: n=0 / Moderate: n=0/ Severe: n=0 Critical: n=0 | |
Primary outcome | |
In the register NR | |
In the report Time needed for resolution of fever, cough, shortness of breath and finally, full recovery from all symptoms and the negative result of repeat RT-PCR on day 10. | |
Documents available |
Protocol NR Statistical plan NR Data-sharing stated NR |
Risk of bias Overall The overall risk of bias reported in the table corresponds to the highest risk of bias for the outcomes assessed for the systematic review |
High |
General comment | Only the published article was used in data extraction and risk of bias assessment as no study registry, protocol or analysis plan was available. No a priori sample size determination was reported. The randomized proportion of participants per group was not reported. Patients were allocated to treatment groups using a quasi-randomisation method, based on odd and even registration numbers in a consecutive fashion. After allocation, a sizeable proportion of patients was not included in the analysis due to the prior duration of symptoms and it is unclear whether this was a post hoc decision. |